Results 21 to 30 of about 184,953,135 (159)

RNA Sequencing Reveals Diverse Functions of Amniotic Fluid Neutrophils and Monocytes/Macrophages in Intra-Amniotic Infection

Journal of Innate Immunity, 2020
Intra-amniotic infection, the invasion of microbes into the amniotic cavity resulting in inflammation, is a clinical condition that can lead to adverse pregnancy outcomes for the mother and fetus as well as severe long-term neonatal morbidities.
Nardhy Gomez-Lopez, Roberto Romero, Aneesha Varrey, Yaozhu Leng, Derek Miller, Bogdan Done, Yi Xu, Gaurav Bhatti, Kenichiro Motomura, Meyer Gershater, Roger Pique-Regi, Adi L. Tarca   +11 more
doaj   +1 more source

Lipidomic analysis of patients with microbial invasion of the amniotic cavity reveals up-regulation of leukotriene B4. [PDF]

FASEB J, 2016
Bioactive lipids derived from the metabolism of polyunsaturated fatty acids are important mediators of the inflammatory response. Labor per se is considered a sterile inflammatory process.
Maddipati KR, Romero R, Chaiworapongsa T, Chaemsaithong P, Chaemsaithong P, Zhou SL, Xu Z, Tarca AL, Kusanovic JP, Gomez R, Chaiyasit N, Honn KV.   +11 more
europepmc   +2 more sources

Preterm prelabor rupture of membranes without microbial invasion of the amniotic cavity and intra-amniotic inflammation: a heterogeneous group with differences in adverse outcomes

, 2022
The absence of microbial invasion of the amniotic cavity and intra-amniotic inflammation at the time of hospital admission is the most common condition associated with preterm prelabor rupture of membranes (PPROM).
Kacerovsky, Marian, Andrys, Ctirad, Spacek, Richard, Jacobsson, Bo,, Musilova, Ivana, Matulova, Jana, Mls, Jan, Bostik, Pavel, Hornychova, Helena, Kukla, Rudolf, Burckova, Hana   +10 more
core   +1 more source

Systemic and local inflammatory response in women with preterm prelabor rupture of membranes.

PLoS ONE, 2014
ObjectiveTo evaluate the inflammatory pattern in maternal circulation, amniotic cavity, cervix and vagina from women with preterm prelabor rupture of membranes (PPROM) considering the occurrence of microbial invasion of the amniotic cavity (MIAC ...
Teresa Cobo, Bo Jacobsson, Marian Kacerovsky, David M Hougaard, Kristin Skogstrand, Eduard Gratacós, Montse Palacio   +6 more
doaj   +1 more source

Bacterial aetiological agents of intra-amniotic infections and preterm birth in pregnant women

Frontiers in Cellular and Infection Microbiology, 2013
Infection-related preterm birth is a leading cause of infant mortality and morbidity; knowledge of bacterial populations invading the amniotic cavity and the routes of invasion is required to make progress in the prevention of preterm birth.
George Louis Mendz, Nadeem O Kaakoush, Julie A Quinlivan   +2 more
doaj   +1 more source

Lack of Evidence for Microbiota in the Placental and Fetal Tissues of Rhesus Macaques

mSphere, 2020
The prevailing paradigm in obstetrics has been the sterile womb hypothesis. However, some are asserting that the placenta, intra-amniotic environment, and fetus harbor microbial communities.
Kevin R. Theis, Roberto Romero, Andrew D. Winters, Alan H. Jobe, Nardhy Gomez-Lopez   +4 more
doaj   +1 more source

No Consistent Evidence for Microbiota in Murine Placental and Fetal Tissues

mSphere, 2020
The existence of a placental microbiota and in utero colonization of the fetus have been the subjects of recent debate. The objective of this study was to determine whether the placental and fetal tissues of mice harbor bacterial communities.
Kevin R. Theis, Roberto Romero, Jonathan M. Greenberg, Andrew D. Winters, Valeria Garcia-Flores, Kenichiro Motomura, Madison M. Ahmad, Jose Galaz, Marcia Arenas-Hernandez, Nardhy Gomez-Lopez   +9 more
doaj   +1 more source

Cervical length and the risk of microbial invasion of the amniotic cavity in women with preterm premature rupture of membranes. [PDF]

J Korean Med Sci, 2007
The aims of this study were to determine whether sonographically measured cervical length is of value in the identification of microbial invasion of the amniotic cavity in women with preterm premature rupture of membranes (PPROM) and to compare its ...
Hong JS, Park KH, Noh JH, Suh YH.
europepmc   +2 more sources

Intra-amniotic inflammatory response in subgroups of women with preterm prelabor rupture of the membranes.

PLoS ONE, 2012
BackgroundTo evaluate the influence of microbial invasion of the amniotic cavity (MIAC) and histological chorioamnionitis (HCA) on the magnitude of intra-amniotic inflammatory response in preterm prelabor rupture of membranes (PPROM).Methodology ...
Teresa Cobo, Marian Kacerovsky, Montse Palacio, Helena Hornychova, David M Hougaard, Kristin Skogstrand, Bo Jacobsson   +6 more
doaj   +1 more source

Proteomic analysis of plasma to identify novel biomarkers for intra-amniotic infection and/or inflammation in preterm premature rupture of membranes

Scientific Reports, 2023
To identify potential plasma biomarkers associated with microbial invasion of the amniotic cavity (MIAC) and/or intraamniotic inflammation (IAI) in women with preterm premature rupture of membranes (PPROM).
Ji Hyun Back, So Yeon Kim, Man Bock Gu, Hyeon Ji Kim, Kyong-No Lee, Ji Eun Lee, Kyo Hoon Park   +6 more
doaj   +1 more source