Results 41 to 50 of about 1,423,870 (260)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Methanogen consortium metabolism characteristic analysis of Illinois basin by real time monitor method [PDF]

, 2010
Microbially Enhance Coalbed Methane technology is used to improve methane content in coalbeds. The methanogen consortium metabolism process is the basic avenue for MECoM to yield methane with some organic compounds in coal. Detailed information about the
Enyuan Wang, Dong Xiao
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Lactobacillus Mucosae Strain Promoted by a High-Fiber Diet in Genetic Obese Child Alleviates Lipid Metabolism and Modifies Gut Microbiota in ApoE^-/- Mice on a Western Diet

Microorganisms, 2020
Supplementation of probiotics is a promising gut microbiota-targeted therapeutic method for hyperlipidemia and atherosclerosis. However, the selection of probiotic candidate strains is still empirical.
Tianyi Jiang, Huan Wu, Xin Yang, Yue Li, Ziyi Zhang, Feng Chen, Liping Zhao, Chenhong Zhang   +7 more
doaj   +1 more source

Multidimensional Optimality of Microbial Metabolism

Science, 2012
Metabolic Networking Understanding complex biological networks, such as those underlying cellular metabolism, requires evaluation not only of the network connections but also the flux through the various biochemical pathways. Schuetz et al.
Schuetz R, Zamboni N, Zampieri M, Heinemann M, Sauer U   +4 more
openaire   +3 more sources

Microbial metabolic exchange in 3D [PDF]

The ISME Journal, 2013
Abstract Mono- and multispecies microbial populations alter the chemistry of their surrounding environments during colony development thereby influencing multicellular behavior and interspecies interactions of neighboring microbes. Here we present a methodology that enables the creation of three-dimensional (3D) models of a microbial ...
Jeramie D Watrous, Vanessa V Phelan, Cheng-Chih Hsu, Wilna J Moree, Brendan M Duggan, Theodore Alexandrov, Pieter C Dorrestein   +6 more
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model [PDF]

, 2008
The transgenomic metabolic effects of exposure to either Lactobacillus paracasei or Lactobacillus rhamnosus probiotics have been measured and mapped in humanized extended genome mice (germ-free mice colonized with human baby flora).
Martin, F. P. J., Martin, F.P.J., LindOn, J.C., Kochhar, S., Holmes, E., Sprenger, N, Fay, L. B., Lindon, J. C., Rochat, F., Kochhar, S, Rezzi, S., Jeremy K Nicholson, Serge Rezzi, Ivan K S Yap, Nicholson, J. K., Rezzi, S, Nicholson, J.K., Ramadan, Z, Laurent B Fay, Yap, IKS, Sunil Kochhar, Yap, K.S., Yulan Wang, Ramadan, Z., Torbjörn Lundstedt, Francois‐Pierre J Martin, Cherbut, C., Wang, Y., Holmes, E, Martin, F-PJ, Peter van Bladeren, Lundstedt, Torbjörn,, Lindon, JC, Ziad Ramadan, John C Lindon, Norbert Sprenger, Fay, L.B., Sprenger, N., Lek, P, Lundstedt, T, Fay, LB, Wang, Y, Yap, I. K. S., Elaine Holmes, Per Lek, Lek, P., van Bladeren, P., Peré-Trepat, E., Nicholson, JK, Bladeren, P.J., van, van Bladeren, P   +50 more
core   +1 more source

Metabolic networks of microbial systems [PDF]

Microbial Cell Factories, 2003
In contrast to bioreactors the metabolites within the microbial cells are converted in an impure atmosphere, yet the productivity seems to be well regulated and not affected by changes in operation variables. These features are attributed to integral metabolic network within the microorganism. With the advent of neo-integrative proteomic approaches the
Bhattacharya Sanjoy K, Nayak Amiya, Chakrabarti Subhra, Bhattacharya Sumana   +3 more
openaire   +3 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source