Results 41 to 50 of about 588,081 (304)

Isotopic and genetic methods reveal the role of the gut microbiome in mammalian host essential amino acid metabolism. [PDF]

, 2020
Intestinal microbiota perform many functions for their host, but among the most important is their role in metabolism, especially the conversion of recalcitrant biomass that the host is unable to digest into bioavailable compounds.
Bradley, Christina J, Feeser, Kelli L, Fogel, Marilyn L, Newsome, Seth D, Takacs-Vesbach, Cristina, Wolf, Caitlin   +5 more
core   +1 more source

Differential Functional Constraints Cause Strain-Level Endemism in Polynucleobacter Populations. [PDF]

, 2016
The adaptation of bacterial lineages to local environmental conditions creates the potential for broader genotypic diversity within a species, which can enable a species to dominate across ecological gradients because of niche flexibility.
Geeta Rijal, Herbert Ssegane, Iratxe Zarraonaindia, Jack A. Gilbert, Janet K. Jansson, Jarrad T. Hampton-Marcell, M. Cristina Negri, Naseer Sangwan, Tifani W. Eshoo   +8 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Host-linked soil viral ecology along a permafrost thaw gradient [PDF]

, 2018
Climate change threatens to release abundant carbon that is sequestered at high latitudes, but the constraints on microbial metabolisms that mediate the release of methane and carbon dioxide are poorly understood1,2,3,4,5,6,7.
Bolduc, Benjamin, Boyd, Joel A., Brum, Jennifer R., Chanton, Jeffrey P., Crill, Patrick M., Emerson, Joanne B., Frolking, Stephen E., Hodgkins, Suzanne B., Jang, Ho Bin, Li, Changsheng, Naas, Adrian E., Pope, Phillip B., Rich, Virginia I., Roux, Simon, Saleska, Scott R., Singleton, Caitlin M., Solden, Lindsey M., Sullivan, Matthew B., Trubl, Gareth, Tyson, Gene W., Wilson, Rachel M., Woodcroft, Ben J., Wrighton, Kelly C.   +22 more
core   +1 more source

Metabolic modeling and analysis of the metabolic switch in Streptomyces coelicolor [PDF]

, 2010
Background The transition from exponential to stationary phase in Streptomyces coelicolor is accompanied by a major metabolic switch and results in a strong activation of secondary metabolism.
Alam, Mohammad T., Breitling, Rainer, HASH(0x55aa09327868), Hodgson, D. A., Merlo, Maria E., Takano, Eriko, Wellington, E. M. H.   +6 more
core   +10 more sources

A widely distributed metalloenzyme class enables gut microbial metabolism of host- and diet-derived catechols. [PDF]

, 2020
Catechol dehydroxylation is a central chemical transformation in the gut microbial metabolism of plant- and host-derived small molecules. However, the molecular basis for this transformation and its distribution among gut microorganisms are poorly ...
Balskus, Emily P, Bess, Elizabeth N, Bisanz, Jordan E, Kiamehr, Sina, Le, Chip, Luescher, Michael U, Maini Rekdal, Vayu, Nol Bernadino, Paola, Turnbaugh, Peter J   +8 more
core   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Lactobacillus Mucosae Strain Promoted by a High-Fiber Diet in Genetic Obese Child Alleviates Lipid Metabolism and Modifies Gut Microbiota in ApoE^-/- Mice on a Western Diet

Microorganisms, 2020
Supplementation of probiotics is a promising gut microbiota-targeted therapeutic method for hyperlipidemia and atherosclerosis. However, the selection of probiotic candidate strains is still empirical.
Tianyi Jiang, Huan Wu, Xin Yang, Yue Li, Ziyi Zhang, Feng Chen, Liping Zhao, Chenhong Zhang   +7 more
doaj   +1 more source

Application of electro-active biofilms [PDF]

, 2010
The concept of an electro-active biofilm (EAB) has recently emerged from a few studies that discovered that certain bacteria which form biofilms on conductive materials can achieve a direct electrochemical connection with the electrode surface using it ...
Dumas, Claire, Duţeanu, Narcis Mihai, Erable, Benjamin, Ghangrekar, Makarand Madhao, Scott, Keith   +4 more
core   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source