Results 51 to 60 of about 82,207 (296)

Deciphering Microbial Diversity and Functional Codes of Traditional Fermented Whole Grain Tianpei from Typical Regions of China

, 2023
Whole grains are a crucial part of healthy and sustainable diets, attracting great attention. Tianpei is a popular traditional fermented whole grain food and beverage from China. It is suitable for all ages with lots of health benefits.
Fei Ren, Xiaohong Tian, Ming Liu, Ping Jiang, Bin Tan, Yanxiang Liu   +5 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

mGem: Revisiting bacterial overflow metabolism

mBio
Bacterial overflow metabolism, where cells perform oxidative fermentation despite the availability of ample oxygen and carbon sources, remains a long-standing paradox in microbial metabolism.
Niaz Bahar Chowdhury, Wheaton L. Schroeder, Lummy Monteiro, Kristin E. Burnum-Johnson   +3 more
doaj   +1 more source

Microbial Metabolites in Colorectal Cancer: Basic and Clinical Implications

Metabolites, 2021
Colorectal cancer (CRC) is one of the leading cancers that cause cancer-related deaths worldwide. The gut microbiota has been proved to show relevance with colorectal tumorigenesis through microbial metabolites. By decomposing various dietary residues in
Yao Peng, Yuqiang Nie, Jun Yu, Chi Chun Wong   +3 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Insights from pharmacokinetic models of host-microbiome drug metabolism

Gut Microbes, 2020
Increasing evidence suggests a role of the gut microbiota in patients’ response to medicinal drugs. In our recent study, we combined genomics of human gut commensals and gnotobiotic animal experiments to quantify microbiota and host contributions to drug
Maria Zimmermann-Kogadeeva, Michael Zimmermann, Andrew L. Goodman   +2 more
doaj   +1 more source

New Insights into the Diurnal Rhythmicity of Gut Microbiota and Its Crosstalk with Host Circadian Rhythm

Animals, 2022
Unlike the strictly hierarchical organization in the circadian clock system, the gut microbiota rhythmicity has a more complex multilayer network of all taxonomic levels of microbial taxa and their metabolites.
Hongyu Wang, He Zhang, Yong Su
doaj   +1 more source

High-Gossypol Whole Cottonseed Exhibited Mediocre Rumen Degradability and Less Microbial Fermentation Efficiency than Cottonseed Hull and Cottonseed Meal with an In Vitro Gas Production Technique

, 2022
To explore whether or not the gossypol varied in cottonseed by-products affect rumen degradability and fermentation efficiency, an in vitro cumulative gas production experiment was applied with mixed rumen microorganism to compare rumen fermentation ...
Shengli Li, Liangkang Lv, Hongjian Yang, Fan Zhang, Weikang Wang, Qichao Wu, Wenjuan Li, Yanlu Wang   +7 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Ecological distribution and population physiology defined by proteomics in a natural microbial community

Molecular Systems Biology, 2010
An important challenge in microbial ecology is developing methods that simultaneously examine the physiology of organisms at the molecular level and their ecosystem level interactions in complex natural systems.
Ryan S Mueller, Vincent J Denef, Linda H Kalnejais, K Blake Suttle, Brian C Thomas, Paul Wilmes, Richard L Smith, D Kirk Nordstrom, R Blaine McCleskey, Manesh B Shah, Nathan C VerBerkmoes, Robert L Hettich, Jillian F Banfield   +12 more
doaj   +1 more source