Results 151 to 160 of about 410,576 (311)
Advanced Science, EarlyView.Parkinson's disease currently has no disease‐modifying therapies. In Caenorhabditis elegans, Escherichia coli E8 alleviates α‐synuclein‐provoked PD‐related defects through its bioactive metabolite 1‐ALPP, which combats PD by triggering AMPK/mTOR/HLH‐30‐dependent autophagy and suppressing α‐synuclein LLPS‐mediated fibrillization.
Mingqin Qu +12 more
wiley +1 more source
Determination of microbiological, chemical, and sensory characteristics of hosmerim desserts derived from sheep, goat, and cow cheese [PDF]
Eurasian Journal of Veterinary SciencesAim: It is aimed to determine the quality characteristics of the hosmerim desserts produced by using goat, sheep and cow cheeses during storage. Materials and Methods: The cheeses have been produced from goat, sheep and cow milk obtained from farms ...
Yılmaz Seçim, Gürkan Uçar
doaj
Immune Biomarkers of Islet Transplant Rejection Revealed by Synthetic Immunological Niche
Advanced Science, EarlyView.A subcutaneous synthetic immunological niche (IN) enables serial, minimally invasive monitoring of immune responses after islet transplantation. Flow cytometry and transcriptomic profiling of the IN reveal immune‐cell programs associated with graft acceptance and distinct types of rejection.
Jyotirmoy Roy +8 more
wiley +1 more source
Advanced Science, EarlyView.Inorganic PbS quantum dots spatially confine AIEgens and enable cooperative luminescence within a ligand‐directed core–shell–shell nanoassembly, generating ultrabright NIR PPANPs with enhanced fluorescence and photothermal performance. The platform enables 10‐min S.
Yujian Li +15 more
wiley +1 more source
Advanced Science, EarlyView.Hydrogel‐forming microneedle (HFMN)‐reservoir patches provide a modular route for controlled transdermal delivery of hydrophilic biomacromolecules. The platform integrates skin‐barrier penetration, sustainable biopolymers, scalable green manufacturing, hydration‐driven transport, model‐cargo validation, and translational quality requirements.
Siddharth Mohanty +4 more
wiley +1 more source
Advanced Science, EarlyView.A biomimetic multi‐layer hygroscopic membrane redistributes salt toward an air‐accessible nanofiber interface, enabling rapid interfacial deliquescence while a brush‐like hydrogel promotes efficient liquid transport and storage. By decoupling vapor capture from bulk water storage, the membrane achieves fast sorption kinetics and enables rapid‐cycling ...
Fu‐Yao Zhong +8 more
wiley +1 more source
Concordance of Microbiological and Histopathological Examination of Bone Biopsies in Diagnosing Diabetic Foot Osteomyelitis, a Systematic Review. [PDF]
J Foot Ankle ResKadiri L, Maher A, Bridgen A.
europepmc +1 more source
Advanced Science, EarlyView.Accurately detecting diverse same‐locus insertions or deletions (indels) remains challenging. This study reveals the mismatch‐tolerance profile of LwaCas13a and establishes CRISPR‐Scan, which uses a single crRNA to detect multiple same‐locus indels. The one‐pot assay detects nucleophosmin 1 (NPM1) mutant allele frequencies down to 0.01%, agrees with ...
Linlin Bai +13 more
wiley +1 more source
Advanced Science, EarlyView.EGFR mutations drive a substantial fraction of non‐small cell lung cancers (NSCLC) and are effectively targeted by tyrosine kinase inhibitors (TKIs), including osimertinib. However, resistance inevitably develops through secondary mutations and compensatory receptor activation, including the GAS6 receptor MERTK.
Suvendu Giri +28 more
wiley +1 more source