Results 161 to 170 of about 410,576 (311)

An Oral Antiviral Combination Against Severe COVID‐19 Enabled by the Synergistic Mechanisms of Action of Auranofin and Remdesivir

Advanced Science, EarlyView.
FDA‐approved anti‐inflammatory drug Auranofin inhibits SARS‐CoV‐2 replication by inhibiting viral Main protease activity and Spike processing required for viral entry. It shows strong synergy with nucleoside analogue Remdesivir, due to non‐overlapping mechanisms.
Oyahida Khatun, Rohan Narayan, Santhosh Kambaiah Nagaraj, Rishad Shiraz, Abinaya Kaliappan, Sumandeep Kaur, Ankur Singh, Siva Shanmugam Selvaraj, Gudepalya Renukaiah Rudramurthy, Chakenahalli Naveenkumar, Shridhar Narayanan, Radha Krishan Shandil, Shailly Tomar, Shashank Tripathi   +13 more
wiley   +1 more source

20-year analysis of protocol-driven quality improvement in cardiac homograft banking. [PDF]

Cell Tissue Bank
Baruji MA, Syed Nong SN, Abdul Aziz KA, Nordin MN, Md Taib ME, Gaaffar IF, Kepli AS, Sallehuddin A.   +7 more
europepmc   +1 more source

HECTD1 Directs HIF‐1α to Facilitate Intestinal Inflammation and Carcinogenesis via Promoting Th17 Differentiation and Glycolysis

Advanced Science, EarlyView.
HECTD1 emerges as an upstream amplifier of Th17 metabolic programming by promoting K63‐linked ubiquitination of IGF2BP3 and enhancing HIF‐1α translation. HIF‐1α reciprocally drives HECTD1 transcription, establishing a positive regulatory loop that sustains glycolysis and Th17 differentiation.
Shuiyu Xu, Qiaoqiao Han, Feixiang Wang, Yuerong Zhang, Haoran Feng, Kun Liu, Fang Xiu Luo, Fei Yuan, Xuesong Zhao, Xiaoyan Yu, Haiyan Huang, Qiang Zou, Ren Zhao   +12 more
wiley   +1 more source

Phosphate‐Engineered DNA Reporters Boost CRISPR‐Cas12a Trans‐Cleavage for Rapid and Sensitive Nucleic Acid Detection

Advanced Science, EarlyView.
We uncover dual CRISPR‐Cas12a trans‐cleavage activities: endonucleolytic cleavage and 3′→5′ exonucleolytic trimming of ssDNA reporters. Mechanism‐guided 3′‐phosphate engineering accelerates substrate cleavage while favoring endonucleolytic processing, enabling Phos‐CRISPR, a rapid (20 min), highly sensitive, and specific platform for nucleic acid ...
Rui Yang, Chong Guo, Minjie Pei, Jiongyu Zhang, Xin Guan, Shuo Zhang, Xingye Liu, Kurt T. Schalper, Lori Avery, Rocco LaSala, David Banach, Changchun Liu   +11 more
wiley   +1 more source

Temporal Trends and Epidemiological Patterns of Clinically Relevant Microorganisms in a Burn Unit: An 11-Year Retrospective Study from a Tertiary Hospital in Southern Brazil. [PDF]

Epidemiologia (Basel)
Palermo RL, Castro IM, Spoladori LFA, Tavares ER, Perugini MRE, Yamauchi LM, Vespero EC, Yamada-Ogatta SF.   +7 more
europepmc   +1 more source

Allium sativum, a Natural and Pharmaco‐Remedial Panacea for Entero‐Gastritis, Antibiocidal/Dysbiogenesis, and Systemic Health Relevance

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Natural Pharmaco‐remedial impacts of Allium sativum on Systemic health. ABSTRACT Arising from the emergence of diverse difficult‐to‐treat health cases, alterative‐therapeutic strategies have become a potential way forward for management/control. In traditional Chinese medicine (TCM), various plant materials have been sourced as alterative‐therapeutic ...
Patience O. Adomi, Bright E. Igere, Anthony J. Anozie, Oghenenyore A. Ohwokevwo   +3 more
wiley   +1 more source

Agronomic and Nutritional Perspectives on Vegetable Crops in Africa

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Vegetable production plays a key role in food security, nutrition, and livelihoods across Africa. Moreover, African indigenous vegetables emerge as underutilized yet highly valuable crops, rich in macro‐ and micronutrients, as well as bioactive compounds with an array of health benefits.
Đorđe Vojnović, Pamela Owusu Osei, Sina Siavash Moghaddam, Issiake Konate, Jelena Popović‐Đorđević   +4 more
wiley   +1 more source

Clinical, etiological, and microbiological differences between foot and non-foot osteomyelitis. [PDF]

Arch Orthop Trauma Surg
Kundakci B, Dalgic Y, Dalkir KA, Olke HC, Mirioglu A, Tekin M.   +5 more
europepmc   +1 more source

Enhancing Elderly Health Through Physical Activities: Insights From a Global Bibliometric Review, 1900–2023

AGING MEDICINE, EarlyView.
Bibliometric analysis reveals rising global research on physical activity and elderly health, dominated by developed nations. Key hotspots include healthy aging, physical activity's mental health benefits, and VR exercise interventions. Promoting physical activity is vital for healthy aging, requiring greater technology integration and research from ...
Hongman Wang, Bo Xie, Can Liu, Yifan Song   +3 more
wiley   +1 more source

Successful Empirical Treatment of a Severe Corneal Abscess After Delayed Consultation in a Low-Resource Setting: A Case Report. [PDF]

Clin Case Rep
Simba GN, Kulimushi FK, Iyimba CM, Murhega RB.   +3 more
europepmc   +1 more source