Establishing What Constitutes a Healthy Human Gut Microbiome: State of the Science, Regulatory Considerations, and Future Directions. [PDF]
On December 17, 2018, the North American branch of the International Life Sciences Institute (ILSI North America) convened a workshop "Can We Begin to Define a Healthy Gut Microbiome Through Quantifiable Characteristics?" with >40 invited academic ...
Antonopoulos +177 more
core +2 more sources
Choice of assembly software has a critical impact on virome characterisation
Background The viral component of microbial communities plays a vital role in driving bacterial diversity, facilitating nutrient turnover and shaping community composition.
Thomas D. S. Sutton +4 more
doaj +1 more source
Alpha-synuclein alters the faecal viromes of rats in a gut-initiated model of Parkinson’s disease
Stockdale et al. assess longitudinal faecal virome changes in a rat model of Parkinson’s Disease (PD) in which either monomeric or preformed fibrils (PFF) of α-synuclein were administered directly into their enteric nervous system.
Stephen R. Stockdale +8 more
doaj +1 more source
Discordant transmission of bacteria and viruses from mothers to babies at birth [PDF]
BACKGROUND: The earliest microbial colonizers of the human gut can have life-long consequences for their hosts. Precisely how the neonatal gut bacterial microbiome and virome are initially populated is not well understood.
Handley, Scott A +8 more
core +2 more sources
Evaluation of the cutaneous microbiome in psoriasis [PDF]
Psoriasis, a highly prevalent disease of humans of unknown cause, is a chronic inflammatory disorder primarily involving skin, with distinctive clinical characteristics.
Alexander Alekseyenko +5 more
core +2 more sources
Diet rapidly and reproducibly alters the human gut microbiome
Long-term dietary intake influences the structure and activity of the trillions of microorganisms residing in the human gut, but it remains unclear how rapidly and reproducibly the human gut microbiome responds to short-term macronutrient change. Here we
Lawrence A. David +12 more
semanticscholar +1 more source
microbiomeMarker: an R/Bioconductor package for microbiome marker identification and visualization
SUMMARY Characterizing biomarkers based on microbiome profiles has great potential for translational medicine and precision medicine. Here, we present microbiomeMarker, an R/Bioconductor package implementing commonly used normalization and differential ...
Yang Cao +5 more
semanticscholar +1 more source
The role of bacteria in pine wilt disease: insights from microbiome analysis. [PDF]
Pine Wilt Disease (PWD) has a significant impact on Eurasia pine forests. The microbiome of the nematode (the primary cause of the disease), its insect vector, and the host tree may be relevant for the disease mechanism.
Alves, Marta +9 more
core +1 more source
SaQuant: a real-time PCR assay for quantitative assessment of Staphylococcus aureus
Background Molecular assays are important tools for pathogen detection but need to be periodically re-evaluated with the discovery of additional genetic diversity that may cause assays to exclude target taxa or include non-target taxa.
Colin Wood +7 more
doaj +1 more source
A core gut microbiome in obese and lean twins
The human distal gut harbours a vast ensemble of microbes (the microbiota) that provide important metabolic capabilities, including the ability to extract energy from otherwise indigestible dietary polysaccharides.
P. Turnbaugh +14 more
semanticscholar +1 more source

