Results 21 to 30 of about 188,933 (418)
Effect of Resveratrol on Blood Rheological Properties in LPS-Challenged Rats
Objectives: Abnormal rheological properties induce adverse effects during sepsis. This study sought to investigate the hypothesis that resveratrol (Res) improves blood rheological properties in rats following a lipopolysaccharide (LPS) challenge, and ...
Ying Wang+9 more
doaj +1 more source
Comparison of the new OPS Imaging technique with intravital microscopy: Analysis of the colon microcirculation [PDF]
Background. The OPS imaging technique has been introduced for in vivo assessment of microcirculation in humans. The aim of this study was to validate the new technique against intravital fluorescence microscopy (IFM) for the visualization of colon ...
Biberthaler, Peter, Langer, S.
core +1 more source
Fast and selective super-resolution ultrasound in vivo with sono-switchable nanodroplets [PDF]
Perfusion by the microcirculation is key to the development, maintenance and pathology of tissue. Its measurement with high spatiotemporal resolution is consequently valuable but remains a challenge in deep tissue. Ultrasound Localization Microscopy (ULM) provides very high spatiotemporal resolution but the use of microbubbles requires low contrast ...
arxiv +1 more source
Diabetes, cardiovascular disease and the microcirculation
Cardiovascular disease (CVD) is the leading cause of mortality in people with type 2 diabetes mellitus (T2DM), yet a significant proportion of the disease burden cannot be accounted for by conventional cardiovascular risk factors.
W. Strain, P. Paldánius
semanticscholar +1 more source
The pancreatic islet is a highly vascularized endocrine micro-organ. The unique architecture of rodent islets, a so-called core-mantle arrangement seen in two-dimensional images, led researchers to seek functional implications for islet hormone secretion.
Michael P. Dybala+6 more
semanticscholar +1 more source
COPD aggravates AS, possibly through the destruction of pulmonary microvascular barrier function; thus, lung inflammation triggers systemic inflammation. In treating COPD with AS, TXL enhances the antiatherosclerotic effect of Ato, protecting the pulmonary microvascular barrier.
Xiangnan Kuang+11 more
wiley +1 more source
Transthoracic super-resolution ultrasound localisation microscopy of myocardial vasculature in patients [PDF]
Micro-vascular flow in the myocardium is of significant importance clinically but remains poorly understood. Up to 25% of patients with symptoms of coronary heart diseases have no obstructive coronary arteries and have suspected microvascular diseases. However, such microvasculature is difficult to image in vivo with existing modalities due to the lack
arxiv +1 more source
Platelet kinetics in the pulmonary microcirculation in vivo assessed by intravital microscopy [PDF]
Growing evidence supports the substantial pathophysiological impact of platelets on the development of acute lung injury. Methods for studying these cellular mechanisms in vivo are not present yet.
Eichhorn, M. E.+3 more
core +1 more source
COVID-19 Sepsis and Microcirculation Dysfunction
The spreading of Coronavirus (SARS-CoV-2) pandemic, known as COVID-19, has caused a great number of fatalities all around the World. Up to date (2020 May 6) in Italy we had more than 28,000 deaths, while there were more than 205.000 infected.
A. Colantuoni+9 more
semanticscholar +1 more source
In this work, we demonstrated that PUM70 specifically suppressed LPS‐mediated inflammatory responses. Notably, PUM70 treatment inhibited LPS‐induced lung damage, pro‐inflammatory cytokine production, and reduced macrophage infiltration in the lungs. Mechanistically, PUM70 suppressed LPS‐induced inflammation and oxidative stress via the Nrf2/HO‐1 and ...
Fei Peng, Xin Ren, Bin Du, Yuedong Yang
wiley +1 more source