Results 21 to 30 of about 77,424 (294)

Selenocysteine induces apoptosis in human glioma cells: evidence for TrxR1-targeted inhibition and signaling crosstalk

open access: yesScientific Reports, 2017
Thioredoxin reductase (TrxR) as a selenium (Se)-containing antioxidase plays key role in regulating intracellular redox status. Selenocystine (SeC) a natural available Se-containing amino acid showed novel anticancer potential through triggering ...
Cun-dong Fan   +11 more
doaj   +1 more source

Chinese herbal remedies affecting thrombosis and hemostasis: A review

open access: yesWorld Journal of Traditional Chinese Medicine, 2015
Acute coronary syndrome, stroke and other ischemic events continue to be the most common causes of mortality and morbidity in the world, and their incidence is rapidly increasing in the developing nations.
Quan Li, Jing-Yu Fan, Jing-Yan Han
doaj   +1 more source

Growth differentiation factor 11 attenuates cardiac ischemia reperfusion injury via enhancing mitochondrial biogenesis and telomerase activity

open access: yesCell Death and Disease, 2021
It has been reported that growth differentiation factor 11 (GDF11) protects against myocardial ischemia/reperfusion (IR) injury, but the underlying mechanisms have not been fully clarified.
Lin Chen   +15 more
doaj   +1 more source

Mesenteric Lymph Drainage Alleviates Acute Kidney Injury Induced by Hemorrhagic Shock without Resuscitation

open access: yesThe Scientific World Journal, 2014
This study aimed to investigate the effect of mesenteric lymph drainage on the acute kidney injury induced by hemorrhagic shock without resuscitation. Eighteen male Wistar rats were randomly divided into sham, shock, and drainage groups.
Zi-Gang Zhao   +4 more
doaj   +1 more source

Schisandrin Attenuates Lipopolysaccharide-Induced Lung Injury by Regulating TLR-4 and Akt/FoxO1 Signaling Pathways

open access: yesFrontiers in Physiology, 2018
Objective: Acute lung injury is a severe clinic condition with limited therapeutic approaches. This study evaluated whether schisandrin (Sch), an ingredient of Schisandra chinensis, has preventive effects on endothelium and epithelium injury induced by ...
Kai Sun   +14 more
doaj   +1 more source

Insights into the toxicological effects of nanomaterials on atherosclerosis: mechanisms involved and influence factors

open access: yesJournal of Nanobiotechnology, 2023
Atherosclerosis is one of the most common types of cardiovascular disease and is driven by lipid accumulation and chronic inflammation in the arteries, which leads to stenosis and thrombosis.
Siyu Chen   +11 more
doaj   +1 more source

The microcirculation in shock [PDF]

open access: yesPostgraduate Medical Journal, 1969
Summary Some aspects of blood fluidity in hypoperfusion with particular reference to the important role of the red cell are discussed. Changes in different organ beds and the internal fluidity of the red cell, which is of obvious importance in capillary flow are not considered.
openaire   +3 more sources

Astaxanthin Attenuates Homocysteine-Induced Cardiotoxicity in Vitro and in Vivo by Inhibiting Mitochondrial Dysfunction and Oxidative Damage

open access: yesFrontiers in Physiology, 2017
Homocysteine (Hcy) as an independent risk factor contributes to the occurrence and development of human cardiovascular diseases (CVD). Induction of oxidative stress and apoptosis was commonly accepted as the major mechanism in Hcy-induced cardiotoxicity.
Cun-dong Fan   +8 more
doaj   +1 more source

The Regulatory Role of GBF1 on Osteoclast Activation Through EIF2a Mediated ER Stress and Novel Marker FAM129A Induction

open access: yesFrontiers in Cell and Developmental Biology, 2021
Bone-resorbing activities of osteoclasts (OCs) are highly dependent on actin cytoskeleton remodeling, plasma membrane reorganization, and vesicle trafficking pathways, which are partially regulated by ARF-GTPases.
Cailing Wen   +12 more
doaj   +1 more source

Advanced glycation endproducts mediate chronic kidney injury with characteristic patterns in different stages

open access: yesFrontiers in Physiology, 2022
Advanced glycation endproducts (AGEs) have been confirmed to play a causative role in the development of diabetic nephropathy (DN). In this study, we revealed that AGE-induced kidney injury with characteristic patterns in different stages and moesin ...
Xiaoxia Huang   +12 more
doaj   +1 more source

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