Results 191 to 200 of about 11,204 (224)
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Characterization of Sublethal Microcystin-LR Exposure in Mice
Veterinary Pathology, 2002Microcystin-LR (MCLR) is a potent hepatotoxin produced by the cyanobacterium Microcystis aeruginosa. The histology of acute lethal toxicity has been well characterized, but histology is limited regarding sublethal exposure. Balb/C mice were given a single sublethal dose of MCLR (45 μg/kg) and euthanized at 2, 4, 12, and 24 hours after exposure ...
R E, Guzman, P F, Solter
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Microcystin-LR-regulated transcriptome dynamics in ZFL cells
Aquatic Toxicology, 2019Microcystin-LR (MC-LR) is a highly toxic hepatotoxin that poses great hazards to aquatic organisms and even human health. The zebrafish liver cell line (ZFL) is a valuable model for investigating toxicity and metabolism of toxicants. However, the toxicity of MC-LR and its effects on gene transcription of ZFL cells remains to be characterized.
Xing, Lu +7 more
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Cyclosporin A — a chemoprotectant against microcystin-LR toxicity
Toxicology Letters, 1990Microcystin-LR (MCLR) is a potent hepatotoxin that rapidly produces death in experimental animals. We have shown that cyclosporin A (CsA) can prevent the toxic and lethal effects of MCLR in mice. The LD50 of MCLR in mice is approximately 61 micrograms/kg, and 100 micrograms/kg produces death in 100% of treated mice.
S J, Hermansky, P J, Casey, S J, Stohs
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Brönsted Catalyzed Hydrolysis of Microcystin-LR by Siderite
Environmental Science & Technology, 2018Six naturally occurring minerals were employed to catalyze the hydrolysis of microcystin-LR (MC-LR) in water. After preliminary screening experiments, siderite stood out among these minerals due to its higher activity and selectivity. In comparison with kaolinite, which is known to act as a Lewis acid catalyst, siderite was found to act primarily as a ...
Yanfen Fang +6 more
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Microcystin-LR adsorption by powdered activated carbon
Water Research, 1994Abstract The adsorption of microcystin-LR by eight different powdered activated carbons (PACs) was investigated and found to vary markedly between carbons. Wood-based carbons were clearly the most effective microcystin-LR adsorbents followed by coal-based PACs. Coconut and peat moss-based carbons were the poorest microcystin-LR adsorbents.
Cosimo Donati +3 more
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Kinetics of Microcystin-LR Oxidation by Ozone
Ozone: Science & Engineering, 2001Abstract The oxidation kinetics of the reaction between dissolved ozone and microcystin-LR, in acidic and neutral buffer solutions over the temperature range of 10 to 30 °C was investigated. Also, the effect of natural organic matter (NOM) on the oxidation of microcystin-LR by ozone was evaluated. The reaction is very rapid and the overall kinetics can
Ayman R. Shawwa, Daniel W. Smith
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Toxicokinetics of (3H)Microcystin-LR in Mice
1990Abstract : The distribution, excretion, and metabolism of (microcystin-LR MCYST- LR, sublethal, iv) were measured in mice. Plasma elimination was biexponential with alpha and beta phase half-lives of 0.8 and 6.9 min, respectively. The apparent volume of distribution of the Beta-phase was 10 ml and the bioavailability was 1036 pmol min/ml.
Wade B. Lawrence +4 more
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Research progress in the functionalization of microcystin-LR based on interdisciplinary technologies
Coordination Chemistry Reviews, 2021Yipeng Liu, Yong Liu
exaly
Immunoassay technology: Research progress in microcystin-LR detection in water samples
Journal of Hazardous Materials, 2022Yipeng Liu, Yong Liu
exaly