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Ms identification of microcystin-LR chlorination by-products [PDF]

Chemosphere, 2009
International audienceDrinking water disinfection by chlorine is known to reduce concentration of microcystin, but compounds formed are rarely considered.
Sylvain Merel
exaly   +2 more sources

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Microbial Degradation of Microcystins

Chemical Research in Toxicology, 2013
Hepatotoxic microcystins that are produced by freshwater cyanobacteria pose a risk to public health. These compounds may be eliminated by enzymatic degradation. Here, we review the enzymatic pathways for the degradation of these hepatotoxins, some of which are newly discovered processes.
Dariusz, Dziga, Marcin, Wasylewski, Benedykt, Wladyka, Sonja, Nybom, Jussi, Meriluoto   +4 more
openaire   +2 more sources

the toxicology of microcystins

Toxicon, 1998
Microcystins are a family of more than 50 structurally similar hepatotoxins produced by species of freshwater cyanobacteria, primarily Microcystis aeruginosa. They are monocyclic heptapeptides, characterised by some invariant amino acids, including one of unusual structure which is essential for expression of toxicity.
openaire   +2 more sources

Microcystin-LR and chemically degraded microcystin-LR electrochemical oxidation

The Analyst, 2012
Microcystins (MCs) are cyclic hepatotoxic heptapeptides produced by certain strains of freshwater cyanobacteria toxic for humans and animals. The electrochemical behaviour of microcystin-LR (MC-LR) at a glassy carbon electrode (GCE) was investigated using cyclic voltammetry (CV), square wave voltammetry (SWV) and differential pulse voltammetry (DPV ...
Ilanna C, Lopes, Paulina V F, Santos, Victor C, Diculescu, Francisco M P, Peixoto, Mário C U, Araújo, Auro A, Tanaka, Ana Maria, Oliveira-Brett   +6 more
openaire   +2 more sources

Methods for determining microcystins (peptide hepatotoxins) and microcystin-producing cyanobacteria

Water Research, 2006
Episodes of cyanobacterial toxic blooms and fatalities to animals and humans due to cyanobacterial toxins (CBT) are known worldwide. The hepatotoxins and neurotoxins (cyanotoxins) produced by bloom-forming cyanobacteria have been the cause of human and animal health hazards and even death.
Lalita N, Sangolkar, Sarika S, Maske, Tapan, Chakrabarti   +2 more
openaire   +2 more sources

Decomposition of Microcystin-LR, Microcystin-RR, and Microcystin-YR in Water Samples Submitted to in Vitro Dissolution Tests

Journal of Agricultural and Food Chemistry, 2004
The presence of cyanobacterial toxins (microcystins) in waters and food increases the risk of toxicity to animal and human health. These toxins can degrade in the human gastrointestinal tract before they are absorbed. To evaluate this possible degradation, water samples spiked with known concentrations of microcystins MC-LR, MC-RR, and MC-YR, which are
Isabel M, Moreno, Judith, Maraver, Esther C, Aguete, Manel, Leao, Ana, Gago-Martínez, Ana M, Cameán   +5 more
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Pyrolytic behaviour of microcystins and microcystin-spiked algal blooms

Journal of Analytical and Applied Pyrolysis, 2005
Peer ...
Cameán Fernández, A. M., Moreno Navarro, I., Verdejo Robles, Trinidad, González-Vila, Francisco Javier, González-Pérez, José Antonio   +4 more
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The biological functions of microcystins

Water Research
Microcystins are potent hepatotoxins predominantly produced by bloom-forming freshwater cyanobacteria (e.g., Microcystis, Planktothrix, Dolichospermum). Microcystin biosynthesis involves large multienzyme complexes and tailoring enzymes encoded by the mcy gene cluster. Mutation, recombination, and deletion events have shaped the mcy gene cluster in the
Nian Wei, Chenlin Hu, Elke Dittmann, Lirong Song, Nanqin Gan   +4 more
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Cyclosporine A inhibition of microcystin toxins

Toxicon, 1990
Cyclosporine A (CyA) given i.v. at a dose of 1.25 mg/mouse blocks a subsequent i.v. lethal dose (1.7-1.8 x LD50) of microcystin-LR for 24 hr, and is about 50% protective at 48 hr. Conversely, the fraction of mice that can be rescued by CyA (0.2 mg/mouse) after a lethal dose of microcystin-LR decreases rapidly with a pharmacodynamic half-time of only ...
R D, Stoner, W H, Adams, D N, Slatkin, H W, Siegelman   +3 more
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Detection of the cyanobacterial hepatotoxins microcystins

Toxicology and Applied Pharmacology, 2005
Concern regarding the presence of microcystins in drinking water and their possible contamination in food (e.g., salad vegetables, fish, shellfish) has resulted in the need for reliable methods for the detection and accurate quantification of this class of toxins.
Jacqui, McElhiney, Linda A, Lawton
openaire   +2 more sources