Results 91 to 100 of about 10,733 (203)

HER-2/neu amplification testing in breast cancer by Multiplex Ligation-dependent Probe Amplification: influence of manual- and laser microdissection

BMC Cancer, 2009
Background Accurate assessment of HER-2/neu status is crucial for proper prognostic information and to offer direct appropriate treatment for breast cancer patients.
Ezendam Chantal, de Weger Roel A, Moelans Cathy B, van Diest Paul J   +3 more
doaj   +1 more source

Molecular, spatial, and AI‐enabled technologies for predicting neoadjuvant therapy response in locally advanced rectal cancer

The Journal of Pathology, EarlyView.
Abstract Pretreatment prediction of neoadjuvant response remains an unresolved challenge in locally advanced rectal cancer, where management is moving towards risk‐adapted and response‐oriented treatment strategies. Prediction remains difficult because response reflects interacting tumour‐intrinsic, immune, stromal, and spatial processes that are ...
Gina F Boot, Cibele Masotti, Claudia Corrò, Cédric Schraepen, Hannah L Williams, Thomas A Wright, Fiza Ishaqwala, Colin W Steele, Gertjan Rasschaert, Maxime W Lafarge, Enric Domingo, Inti Zlobec, Rodrigo Oliva Perez, Campbell SD Roxburgh, Timothy S Maughan, Sabine Tejpar, Thibaud Koessler, Viktor H Koelzer   +17 more
wiley   +1 more source

Gene amplification elucidated by combined chromosomal microdissection and comparative genomic hybridization

, 1995
Gene amplification is an important manifestation of genetic instability in cancer. Recently, the study of gene amplification has been greatly facilitated by the development of the molecular cytogenetic techniques of comparative genomic hybridization and ...
Guan, XY, Trent, JM, Meltzer, PS, Liang, BC, Jeffrey M. Trent, Paul S. Meltzer, Xin-Yuan Guan, Bertrand C. Liang   +7 more
core   +1 more source

Role of testicular fine‐needle aspiration in the modern male reproductive urologist′s practice

UroPrecision, EarlyView.
Abstract Background Azoospermia affects 10%–15% of infertile men, with non‐obstructive azoospermia (NOA) most often managed by microdissection testicular sperm extraction (mTESE). Despite AUA/ASRM guidelines recommending mTESE, some urologists employ testicular fine‐needle aspiration (TFNA) mapping as a diagnostic adjunct.
Parth Joshi, Jordan Kassab, Vivek Aslot, Richard Schoor   +3 more
wiley   +1 more source

Characterization of isolated late preantral and early antral equine ovarian follicles

Reproduction and Fertility
Understanding how to effectively isolate a large number of healthy follicles is essential for increasing success rates in ARTs, such as in vitro culture and cryopreservation.
Ana Normélia P Morais, Gustavo D A Gastal, Francisco L N Aguiar, Kendall A Hyde, Melba O Gastal, Laritza F Lima, Lucy V S Ñaupas, Ana Flávia B Silva, Verónica A B Becerra, Luiza Gheno, Bruna R Curcio, Carine D Corcini, Ana Paula R Rodrigues, José R Figueiredo, Antonio S Varela Jr, Eduardo L Gastal   +15 more
doaj   +1 more source

Plastic and adaptive mitochondrial responses help face hypoxia events in a freshwater fish

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Hypoxic events (i.e. reduction of dissolved oxygen in water) are natural events, which intensity and frequency have been amplified by human activities. As oxygen fuels aerobic metabolism, species unable to avoid those events must maintain their functions through ...
Eugénie Dereuder, Tiphaine Menguy, Antoine Stier, Katja Anttila, Amélie Crespel   +4 more
wiley   +1 more source

Laser capture microdissection

Nature Reviews Methods Primers
The tissue microenvironment was once viewed as an impossibly complex heterogeneous ecosystem. Today, tools and data analysis methods probe tissues at multiple resolution levels, from subpopulations to individual cells and individual molecules. Laser capture microdissection (LCM) was one of the first technologies enabling spatial molecular interrogation
Lance A. Liotta, Thomas P. Conrads, Marissa A. Howard, Robyn P. Araujo, Emanuel F. Petricoin   +4 more
openaire   +2 more sources

Assessing a Model for a Complex Systemic Disorder—The Value of Male Mice With a Supernumerary X Chromosome for Klinefelter Syndrome Research

Andrology, EarlyView.
ABSTRACT Introduction Direct experimental investigation of Klinefelter syndrome (KS) in patients is limited because the syndrome manifests heterogeneously and affects multiple organ systems. Studying KS therefore requires a model that captures this complexity as accurately as possible while still permitting controlled experimental manipulation ...
Fariba Saadati, Joachim Wistuba
wiley   +1 more source

Fresh Versus Frozen Testicular Sperm Samples in Microdissection Testicular Sperm Extraction Intracytoplasmic Sperm Injection Treatment

Gynecology Obstetrics & Reproductive Medicine, 2017
Objective: The present study aims to compare the clinical outcomes of fresh versus frozen testicular samples in patients with non-obstructive azoospermia who would undergo intracytoplasmic sperm injection procedure.
Şafak Hatırnaz, Serdar Başaranoğlu, Ebru Hatırnaz, Mine Kanat Pektaş   +3 more
doaj   +1 more source

Microdissection and Analytical PCR for the Investigation of mtDNA Lesions

, 2007
This chapter provides an overview of microdissection and analytical polymerase chain reaction (PCR) techniques and some example protocols applicable to the study of mitochondrial DNA (mtDNA).
Williams, Sion L, Carlos T. Moraes, Sion L. Williams, Moraes, Carlos T   +3 more
core   +1 more source