Results 71 to 80 of about 10,733 (203)

Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics

Nanomaterials, 2018
In calcific aortic valve disease (CAVD), microcalcifications originating from nanoscale calcifying vesicles disrupt the aortic valve (AV) leaflets, which consist of three (biomechanically) distinct layers: the fibrosa, spongiosa, and ventricularis.
Dewy C. van der Valk, Casper F. T. van der Ven, Mark C. Blaser, Joshua M. Grolman, Pin-Jou Wu, Owen S. Fenton, Lang H. Lee, Mark W. Tibbitt, Jason L. Andresen, Jennifer R. Wen, Anna H. Ha, Fabrizio Buffolo, Alain van Mil, Carlijn V. C. Bouten, Simon C. Body, David J. Mooney, Joost P. G. Sluijter, Masanori Aikawa, Jesper Hjortnaes, Robert Langer, Elena Aikawa   +20 more
doaj   +1 more source

Identification of region specific genes by chromosome microdissection

, 1997
Chromosome microdissection is an extremely useful molecular cytogenetic tool for the characterization of chromosomal abnormalities in tumor cells.
Guan, XY, Trent, JM, Meltzer, PS, Su, YA, Gracia, E, Yan An Su, Jeffrey M. Trent, Paul S. Meltzer, Xin-Yuan Guan, Edgardo Gracia   +9 more
core   +1 more source

Gene Expression Biomarkers for Breast Ductal Carcinoma in Situ Recurrence Prediction

International Journal of Cancer, EarlyView.
ABSTRACT Breast ductal carcinoma in situ (DCIS) is often overtreated due to a lack of robust prognostic and predictive tools. This study aimed to evaluate gene expression in a well‐characterised DCIS cohort to determine their clinical utility as biomarkers for ipsilateral recurrence. RNA was extracted from microdissected tissues from primary DCIS.
Alexandria Un, Sakshi Mahale, David Byrne, Dorothea Lesche, Carlos Martinez‐Perez, Jia‐Min Pang, Maree Pechlivanis, Hugo Saunders, Madawa W. Jayawardana, Tongtong Luo, Sureshni I. Jayasinghe, Tanjina Kader, Lisa Devereux, Puay Hoon Tan, Andrew R. Green, Emad A. Rakha, Arran K. Turnbull, Stephen B. Fox, G. Bruce Mann, Kylie L. Gorringe   +19 more
wiley   +1 more source

TP53 Abnormalities are frequent and early events in the sequential pathogenesis of gallbladder carcinoma§

Annals of Hepatology, 2005
Background: Gallbladder carcinoma (GBC) is a frequent neoplasm in Hispanic and native American populations. GBC is preceded by gallstones, chronic cholecystitis and dysplastic changes of the gallbladder epithelium.
Mauricio Moreno, Fernando Pimentel, Adi F. Gazdar, Ignacio I. Wistuba, Juan F. Miquel   +4 more
doaj   +1 more source

Dental caries shallow-layer microbe harvest and data display method shows taxa pre-harvest spatial positions, absolute and relative abundance and diversity related to lesion pulpal depth

Journal of Oral Microbiology
Background Molecular identification of dental caries microbes is advancing rapidly, yet sampling methods remain outdated and imprecise.Objective To refine microbe sample harvesting and preserve taxa pre-harvest spatial positions relative to lesion pulpal
Rella P. Christensen, Brad J. Ploeger, Kaesy R. Barker, Wyatt R. Hume, Brenda Heaton   +4 more
doaj   +1 more source

Perineural invasion in pancreatic cancer: proteomic analysis and in vitro modelling

Molecular Oncology, 2019
Perineural invasion (PNI) is a common and characteristic feature of pancreatic ductal adenocarcinoma (PDAC) that is associated with poor prognosis, tumor recurrence, and generation of pain.
Wasfi Alrawashdeh, Richard Jones, Laurent Dumartin, Tomasz P. Radon, Pedro R. Cutillas, Roger M. Feakins, Branko Dmitrovic, Ihsan Ekin Demir, Guralp O. Ceyhan, Tatjana Crnogorac‐Jurcevic   +9 more
doaj   +1 more source

Site-specific gene expression profiling as a novel strategy for unravelling keloid disease pathobiology. [PDF]

PLoS ONE, 2017
Keloid disease (KD) is a fibroproliferative cutaneous tumour characterised by heterogeneity, excess collagen deposition and aggressive local invasion.
N Jumper, T Hodgkinson, R Paus, A Bayat
doaj   +1 more source

Single‐Cell RNA Sequencing and Spatial Multiomics Unveil Microglia–Mural Interactions Underlying Notoginsenoside R1 Against Ischemic Stroke

iMetaMed, EarlyView.
Integrated scRNA‐seq and spatial multiomics provide single‐cell and spatial insights into the neuroprotective effects of NGR1, a clinically validated bioactive compound from Panax notoginseng. NGR1 was associated with a shift in microglial transcriptional states away from ischemia‐associated pro‐inflammatory Adam8hi microglia and toward the protective ...
Qikun Zhao, Wenbo Guo, Yanrong Zheng, Guoqian Cui, Bingjie Wan, Shuhui Deng, Hudong Bao, Xiao Tu, Shengshuang Chen, Jie Liao, Xiaohui Fan   +10 more
wiley   +1 more source

Comparison of Tissue Repair with Different Types of Microdissection Tips: A Randomized Histomorphometric Evaluation in Rats

Bioengineering
The aim of the study was to compare tissue repair of incisions made using different microdissection electrocautery tips in an in vivo animal model. Skin incisions were made, including the subcutaneous tissue, in 30 adult Wistar rats using four types of ...
Ana Luiza Vila Verde Brunelli, Luíz Henrique Soares Torres, Arthur Henrique Alécio Viotto, Izabela Fornazari Delamura, Ana Paula Farnezi Bassi, Marisa Aparecida Cabrini Gabrielli, Valfrido Antonio Pereira-Filho   +6 more
doaj   +1 more source

Isolation and genome sequencing of individual circulating tumor cells using hydrogel encapsulation and laser capture microdissection

, 2018
Single CTC sequencing workflow using biophysical enrichment and single cell isolation by laser capture microdissection.
Richard A. Ang, Xiaoyan Deng, Alexander W. Wyatt, Emily S. Park, Jeong Hyun Lee, Peter C. Black, Hongshen Ma, Justin P. Yan, Kim N. Chi, Simon P. Duffy, Kevin Beja, Matti Annala   +11 more
core   +1 more source