Results 51 to 60 of about 10,733 (203)

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

open access: yesAdvanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi   +7 more
wiley   +1 more source

Sample preparation for laser-microdissection of soybean shoot apical meristem

open access: yes, 2012
The shoot apical meristem houses stem cells responsible for the continuous formation of aerial plant organs including leaves and stems throughout the life of plants.
Mohan Singh   +5 more
core   +1 more source

Enhanced molecular analyses by combination of the HOPE-technique and laser microdissection [PDF]

open access: yes, 2006
As part of an investigation aimed at illuminating the possibilities and limits of the HOPE-fixation and paraffin-embedding technique we here describe a novel procedure which was developed in order to combine the benefits of the HOPE-technique with the ...
Peter Zabel   +15 more
core   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

open access: yesAdvanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan   +8 more
wiley   +1 more source

Identification and characterization of a bacteria-like sequence in the genome of some Silene species

open access: yesBiologia Plantarum, 2012
The aim of this work was to characterize a nucleotide sequence MK14 that originated from a plasmid library obtained via degenerate oligonucleotide primed polymerase chain reaction (DOP-PCR) amplification of laser microdissected Y-chromosomes of Silene ...
M. Talianová   +4 more
doaj   +1 more source

Mechanical pencils for microdissection [PDF]

open access: yes, 2019
Replacing the lead of a 'fine line' mechanical pencil with an entomological pin produces a convenient, adjustable probe for microdissection ...
Halford, S. A.
core  

Histology of hippocampal sections before and after laser microdissection.

open access: yes, 2013
Photomicrograph of a typical HistoGene-stained coronal section through the hippocampus of a 3-day-old mouse (a), and the same section following excision of the hippocampal pyramidal layer by microdissection on a Leica ASLMD laser capture microdissection ...
Jie Bai (28269)   +5 more
core   +1 more source

Single‐Cell Insights Into Pathogenic Profile of Orchitis and SREBP2‐Associated Cholesterol Dysregulation in Spermatogenic Failure

open access: yesAdvanced Science, EarlyView.
A first single‐cell atlas of human orchitis reveals coordinated germ‐cell loss, somatic niche dysfunction, and immune‐metabolic remodeling. Aberrant SREBP2 activation in testicular somatic cells emerges as a central pathogenic node, while Fatostatin‐mediated inhibition of the SREBP pathway improves spermatogenesis, fibrosis, and lipid accumulation in a
Yanlin Tang   +16 more
wiley   +1 more source

Laser microdissection microscopy in parasitology: microscopes meet thermocyclers

open access: yes, 2004
The new methods of laser microdissection microscopy have received wide acceptance in biology and have been applied in a small number of parasitology investigations.
McManus, Donald P.   +3 more
core   +1 more source

MetaPaCS: A Novel Meta‐Learning Framework for Pancreatic Cancer Subtype Identification

open access: yesAdvanced Intelligent Systems, EarlyView.
We have developed MetaPaCS, an ensemble meta‐learning framework for reliable prediction of pancreatic cancer subtypes with high accuracy. MetaPaCS is capable of capturing subtype‐specific distinct gene expression patterns and drug‐disease associations for pancreatic cancer.
Nick B. Peterson   +4 more
wiley   +1 more source

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