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Laryngeal Tumor Microenvironment
2020Tumor microenvironment has been extensively studied in various forms of cancer, like head and neck squamous cell carcinoma. Progress in the field revealed the prognostic significance of the various components of the tumor's ecosystem and led to changes in treatment strategies, like including immunotherapy as an important tool.
Georgia, Karpathiou +2 more
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Endometrial Tumour Microenvironment
2020Endometrial cancer (EC) is the most common gynaecological tumour in developed countries, and its incidence is increasing in part due to the prevalence of obesity and its related hormone dysregulation. As described in this chapter, the tumour microenvironment plays a principal role in unopposed oestrogen stimulation promoting tumour cell proliferation ...
Carlos, Casas-Arozamena, Miguel, Abal
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Gastric Tumor Microenvironment
2020A compelling body of evidence has demonstrated that gastric cancer has a very particular tumor microenvironment, a signature very suitable to promote tumor progression and metastasis. Recent investigations have provided new insights into the multiple molecular mechanisms, defined by genetic and epigenetic mechanisms, supporting a very active cross talk
Armando, Rojas +3 more
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Meningioma Tumor Microenvironment
2020The tumor microenvironment consists of noncancerous cells, such as immune cells and fibroblasts, and the proteins produced by these cells as well as the extracellular matrix components in the environment around a tumor. Tumor influences the behavior of the cells present in the surrounding environment, while the cells in the tumor microenvironment ...
Sajad, Sahab-Negah, Ali, Gorji
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Synthetic tumor microenvironments
Nature Methods, 2021An artificial system models the mechanical properties of the tumor microenvironment in vitro.
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Sarcoma Tumor Microenvironment
2020Components of the tumor microenvironment (TME) are known to play an essential role during malignant progression, but often in a context-dependent manner. In bone and soft tissue sarcomas, disease-regulatory activities in the TME remain largely uncharacterized. This chapter introduces the cellular, structural, and chemical composition of the sarcoma TME
Panagiotis, Tsagozis +7 more
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Appendix Tumor Microenvironment
2020The pathological features of the appendix tumors fundamentally recall those of the more frequent colorectal neoplasms, although with a higher relative incidence of carcinoids, due to the abundant presence of enteroendocrine cells in the appendix wall. Moreover, different types of lymphomas, Hodgkin and non-Hodgkin, arising from the extra-nodal mucosal ...
Luca, Roncati +5 more
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Microenvironment: Neighbourhood watch
Nature, 2011In the fight against myeloma, researchers are investigating its interactions with molecular neighbours in the bone marrow.
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Immunology Today, 1993
Abstract The thymus has been recognized as a site of primary immune function for more than three decades and yet, despite intense research, many of the central questions regarding its function in T-lymphocyte maturation have remained unanswered. Current cellular and molecular analytical techniques are finally proving to be sophisticated enough to ...
R L, Boyd +9 more
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Abstract The thymus has been recognized as a site of primary immune function for more than three decades and yet, despite intense research, many of the central questions regarding its function in T-lymphocyte maturation have remained unanswered. Current cellular and molecular analytical techniques are finally proving to be sophisticated enough to ...
R L, Boyd +9 more
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Targeting the microenvironment
Leukemia & Lymphoma, 2010The microenvironment in which cancer arises plays a critical role in tumorigenesis. Although previously regarded as an innocent bystander, evidence has accumulated over the past 10 years that the microenvironment contributes to tumor growth and progression by providing nutrients and survival signals, and protecting the tumor from normal immune ...
John, Gribben +3 more
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