Results 71 to 80 of about 734,316 (316)

Review of the Tumor Microenvironment in Basal and Squamous Cell Carcinoma

, 2023
It is widely known that tumor cells of basal and squamous cell carcinoma interact with the cellular and acellular components of the tumor microenvironment to promote tumor growth and progression. While this environment differs for basal and squamous cell
Stafford, Haleigh, Chiang, Elizabeth, Migden, Michael, Uma Ramesh, Moran Amit, Nagarajan, Priyadharsini, Haleigh Stafford, Jane Buell, Elizabeth Chiang, Buell, Jane, Ramesh, Uma, Priyadharsini Nagarajan, Yaniv, Dan, Amit, Moran, Michael Migden, Dan Yaniv   +15 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

CXCR4, CXCR7 and PBRM1 are responsible for everolimus and cabozantinib resistance in human renal cancer cells

Cell Death Discovery
The mTOR inhibitor everolimus (RAD001), previously used in first-line treatment of metastatic renal cancer (mRCC), is currently reserved for the following lines of therapy. However, many patients eventually develop resistance to RAD001. To shed new light
Federica Auletta, Caterina Ieranò, Dario Guido Di Febbraro, Anna Maria Bello, Giuseppina Rea, Maria Napolitano, Francesca Galdiero, Giuseppe Guardascione, Anna Maria Trotta, Sara Santagata, Cinzia Vetrei, Gaetana Di Maiolo, Daniela Russo, Anna Spina, Crescenzo D’Alterio, Luigi Portella, Serena Ascrizzi, Giovanni Luca Scaglione, Pierfrancesco Tassone, Maria Teresa Di Martino, Stefania Scala   +20 more
doaj   +1 more source

Glycocalyx Acts as a Central Player in the Development of Tumor Microenvironment by Extracellular Vesicles for Angiogenesis and Metastasis

, 2022
Angiogenesis in tumor growth and progression involves a series of complex changes in the tumor microenvironment. Extracellular vesicles (EVs) are important components of the tumor microenvironment, which can be classified as exosomes, apoptotic vesicles,
Zeng, Ye, Bingmei M. Fu, Qiu, Yan, Ye Zeng, Fu, Bingmei M., Jiang, Wenli, Yan Qiu, Wenli Jiang   +7 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Biochemical‐ and Biophysical‐Induced Barriergenesis in the Blood–Brain Barrier: A Review of Barriergenic Factors for Use in In Vitro Models

Advanced NanoBiomed Research, 2021
Central nervous system (CNS) pathologies are a prevalent problem in aging populations, creating a need to understand the underlying events in these diseases and develop efficient CNS‐targeting drugs.
Christina L. Schofield, Aleixandre Rodrigo-Navarro, Matthew J. Dalby, Tom Van Agtmael, Manuel Salmeron-Sanchez   +4 more
doaj   +1 more source

The Landscape and Clinical Application of the Tumor Microenvironment in Gastroenteropancreatic Neuroendocrine Neoplasms

, 2022
SIMPLE SUMMARY: The tumor microenvironment (TME) plays a role in promoting tumor progression. Elucidating the relationship between the TME and tumor cells will benefit current therapies.
Chen, Ruyin, Xu, Shuaishuai, Ruyin Chen, Shuaishuai Xu, Ye, Chanqi, Ruan, Jian, Qiong Li, Jian Ruan, Li, Qiong, Chanqi Ye   +9 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Treatment with oncolytic vaccinia virus infects tumor-infiltrating regulatory and exhausted T cells

Journal for ImmunoTherapy of Cancer
Background Oncolytic viruses (OVs) are an attractive way to increase immune infiltration into an otherwise cold tumor. While OVs are engineered to selectively infect tumor cells, there is evidence that they can infect other non-malignant cells in the ...
Greg M Delgoffe, Kristin DePeaux, William G Gunn, Dayana B Rivadeneira   +3 more
doaj   +1 more source

Interactions between Platelets and Tumor Microenvironment Components in Ovarian Cancer and Their Implications for Treatment and Clinical Outcomes

, 2023
Platelets, the primary operatives of hemostasis that contribute to blood coagulation and wound healing after blood vessel injury, are also involved in pathological conditions, including cancer. Malignancy-associated thrombosis is common in ovarian cancer
Selin Oncul, Min Soon Cho
core   +1 more source