Results 61 to 70 of about 734,316 (316)

Cancer Stem Cells in Tumor Microenvironment of Adenocarcinoma of the Stomach, Colon, and Rectum

, 2022
SIMPLE SUMMARY: Gastrointestinal cancers have a high mortality rate worldwide, and the progression of the disease is related to cancer stem cells. Until now, its relationship with the microenvironment has been poorly understood. We describe the molecules
Carlos A. Gonzalez-Villarreal, Garza-Treviño, Elsa N., Islas, Jose Francisco, Delgado-Gonzalez, Paulina, Juan Luis Delgado-Gallegos, Delgado-Gallegos, Juan Luis, Jose Francisco Islas, Elsa N. Garza-Treviño, Hector Franco-Villarreal, Franco-Villarreal, Hector, Paulina Delgado-Gonzalez, Adriana G. Quiroz-Reyes, Gonzalez-Villarreal, Carlos A., Quiroz-Reyes, Adriana G.   +13 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Carnitine palmitoyltransferase 1C promotes EMT-associated cisplatin resistance in non-small cell lung cancer cells

Cancer Biology & Medicine
Objective: Lung cancer is the most common cause of cancer-related deaths worldwide. Platinum-based chemotherapy is one of the main treatment options for patients with non-small cell lung cancer (NSCLC) but the effectiveness of chemotherapy is encumbered ...
Renjie Chen, Jiahui Wang, Shuoyu Huang, Xuefeng Hu, Xinran He, Tiange Zhang, Yunhan Hu, Huijun Wei, Sihui Nian, Yushu Huang, Zhihao Wu   +10 more
doaj   +1 more source

Combined Effects of Myeloid Cells in the Neuroblastoma Tumor Microenvironment

, 2021
Despite multimodal treatment, survival chances for high-risk neuroblastoma patients remain poor. Immunotherapeutic approaches focusing on the activation and/or modification of host immunity for eliminating tumor cells, such as chimeric antigen receptor ...
Leontari, Ilia, Anderson, John, Frosch, Jennifer, Jennifer Frosch, Ilia Leontari, John Anderson   +5 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

IRE1α‐XBP1s axis regulates SREBP1‐dependent MRP1 expression to promote chemoresistance in non‐small cell lung cancer cells

Thoracic Cancer
Background Inositol‐requiring enzyme 1 (IRE1) is an endoplasmic reticulum (ER)‐resident transmembrane protein that senses ER stress and mediates an essential arm of the unfolded protein response (UPR).
Yuzhou Xu, Feng Gui, Zhe Zhang, Zhongyang Chen, Tiange Zhang, Yunhan Hu, Huijun Wei, Yuchen Fu, Xinde Chen, Zhihao Wu   +9 more
doaj   +1 more source

Tumor Microenvironment as a Therapeutic Target in Melanoma Treatment

, 2023
The role of the tumor microenvironment in tumor growth and therapy has recently attracted more attention in research and drug development. The ability of the microenvironment to trigger tumor maintenance, progression, and resistance is the main cause for
Thomas W. Flanagan, Kharouf, Naji, Hassan, Sofie-Yasmin, Khabaz, Marla, Marla Khabaz, Sofie-Yasmin Hassan, Flanagan, Thomas W., Hassan, Sarah-Lilly, Mosaad Megahed, Megahed, Mosaad, Sarah-Lilly Hassan, Hassan, Sofie Yasmin, Hassan, Mohamed, Hosam Shalaby, Simeon Santourlidis, Mohamed Hassan, Santourlidis, Simeon, Hassan, Sarah Lilly, Shalaby, Hosam, Naji Kharouf, Youssef Haikel, Haikel, Youssef   +21 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

A digest on the role of the tumor microenvironment in gastrointestinal cancers

, 2010
Experimental studies and analyses of clinical material have convincingly demonstrated that tumor formation and progression occurs through a concerted action of malignant cells and the surrounding microenvironment of the tumor stroma.
Augsten, M,, Hägglöf, Christina,, Pena, C, Ostman, A, Hagglof, C, Peña, Cristina,, Augsten, Martin,, Ostman, Arne,   +7 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source