Results 41 to 50 of about 734,316 (316)
Nature Communications, 2021 Cancer derived exosomes are reported to promote metastatic dissemination. Here the authors show that cytokines in the tumor microenvironment bind to exosomes via glycosaminoglycan side chains of proteoglycans, and these exosomes are preferentially taken ...
Luize G. Lima +11 more
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Targeting Tie2 in the Tumor Microenvironment: From Angiogenesis to Dissemination
, 2021 The Tie2 receptor tyrosine kinase is expressed in vascular endothelial cells, tumor-associated macrophages, and tumor cells and has been a major focus of research in therapies targeting the tumor microenvironment.
George S. Karagiannis +5 more
core +1 more source
Functional characterization of ABCA4 genetic variants related to Stargardt disease
Scientific Reports, 2022 The ATP-binding cassette subfamily 4 (ABCA4), a transporter, is localized within the photoreceptors of the retina, and its genetic variants cause retinal dystrophy. Despite the clinical importance of the ABCA4 transporter, a few studies have investigated
Bo Min Kim +6 more
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DNA Damage Response in Multiple Myeloma: The Role of the Tumor Microenvironment
, 2021 Multiple myeloma (MM) is an incurable plasma cell malignancy characterized by genomic instability. MM cells present various forms of genetic instability, including chromosomal instability, microsatellite instability, and base-pair alterations, as well as
Takayuki Saitoh, Tsukasa Oda
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Anti-S100A4 Antibody Suppresses Metastasis Formation by Blocking Stroma Cell Invasion
Neoplasia: An International Journal for Oncology Research, 2012 The small Ca-binding protein, S100A4, has a well-established metastasis-promoting activity. Moreover, its expression is tightly correlated with poor prognosis in patients with numerous types of cancer.
Jörg Klingelhöfer +6 more
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Targeting cellular senescence to combat cancer and ageing
Molecular Oncology, 2022 Senescence is a complex cellular process that is implicated in various physiological and pathological processes. It is characterized by a stable state of cell growth arrest and by a secretome of diverse pro‐inflammatory factors, chemokines and growth ...
Chen Wang, Xue Hao, Rugang Zhang
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GM‐CSF enhances tumor invasion by elevated MMP‐2, ‐9, and ‐26 expression
Cancer Medicine, 2013 Granulocyte–macrophage colony‐stimulating factor (GM‐CSF) promotes tumor progression in different tumor models in an autocrine and paracrine manner. However, at the same time GM‐CSF is used in cancer therapies to ameliorate neutropenia.
Claudia M. Gutschalk +5 more
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Cell Death and Disease, 2022 Androgen receptor (AR) signaling plays important roles in breast cancer progression. We show here that Kindlin-2, a focal adhesion protein, is critically involved in the promotion of AR signaling and breast cancer progression.
Luyao Ma +13 more
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Zhongliu Fangzhi Yanjiu, 2022 Objective To explore the related genes that play a key regulatory role in cisplatin resistance in lung adenocarcinoma. Methods Bioinformatics methods were used to download the differentially-expressed genes between cisplatin sensitive group and drug ...
WANG Lin +5 more
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Modeling the Tumor Microenvironment and Cancer Immunotherapy in Next-Generation Humanized Mice
, 2023 Cancer immunotherapy has brought significant clinical benefits to numerous patients with malignant disease. However, only a fraction of patients experiences complete and durable responses to currently available immunotherapies.
Dietmar Herndler-Brandstetter +2 more
core +1 more source