Results 21 to 30 of about 734,316 (316)
Cancer-Associated Fibroblasts in the Hypoxic Tumor Microenvironment
, 2022 SIMPLE SUMMARY: Cancers have regions of low oxygen concentration where hypoxia-related signaling pathways are activated. The hypoxic tumor microenvironment has been widely accepted as a hallmark of cancer and shown to be a critical factor in the ...
Yoo, Seongkyeong +9 more
core +1 more source
Clinical Strategies Targeting the Tumor Microenvironment of Pancreatic Ductal Adenocarcinoma
, 2022 Pancreatic cancer has a complex tumor microenvironment which engages in extensive crosstalk between cancer cells, cancer-associated fibroblasts, and immune cells. Many of these interactions contribute to tumor resistance to anti-cancer therapies.
Christine Alewine +7 more
core +1 more source
Firing up the cold tumors by targeting Vps34
OncoImmunology, 2020 Cancer immunotherapy based on anti-PD-1/PD-L1 blockade is particularly effective in responding to patients with hot tumors. These tumors are characterized by the accumulation of proinflammatory cytokines and T cell infiltration.
Bassam Janji +4 more
doaj +1 more source
The emerging roles of MAPK-AMPK in ferroptosis regulatory network
Cell Communication and Signaling, 2023 Ferroptosis, a newform of programmed cell death, driven by peroxidative damages of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes and is extremely dependent on iron ions, which is differs characteristics from traditional cell ...
Xinyue Wang +4 more
doaj +1 more source
iScience, 2021 Summary: Therapy-induced senescence-associated secretory phenotype (SASP) correlates with overcoming resistance to immune checkpoint blockade (ICB). Intrinsic resistance to ICB is a major clinical challenge.
Xue Hao +6 more
doaj +1 more source
Telocytes in the Tumor Microenvironment
, 2021 There are several theories explaining the communication between cells in the context of tumor development. Over the years, interactions between normal and transformed cells have been observed. Generally, all types of cells make equal contributions to the formation of the tumor microenvironment - a location of primary oncogenesis.
Aleksandrovych, Veronika, Gil, Krzysztof
openaire +3 more sources
Modelling the Tumour Microenvironment, but What Exactly Do We Mean by “Model”? [PDF]
, 2023 The Oxford English Dictionary includes 17 definitions for the word “model” as a noun and another 11 as a verb. Therefore, context is necessary to understand the meaning of the word model.
Constantino Carlos Reyes-Aldasoro +1 more
core +1 more source
Mycosis Fungoides and Sézary Syndrome: Microenvironment and Cancer Progression
, 2023 Mycosis fungoides and Sézary syndrome are epidermotropic cutaneous lymphomas, and both of them are rare diseases. Mycosis fungoides is the most frequent primary cutaneous lymphoma.
Gabor Dobos +2 more
core +1 more source
Optimized exosome isolation protocol for cell culture supernatant and human plasma [PDF]
Journal of Extracellular Vesicles, 2015 Extracellular vesicles represent a rich source of novel biomarkers in the diagnosis and prognosis of disease. However, there is currently limited information elucidating the most efficient methods for obtaining high yields of pure exosomes, a subset of ...
Richard J. Lobb +6 more
doaj +1 more source
Lysophospholipid Signalling and the Tumour Microenvironment
, 2021 Homeostasis is the key to survival. This is as true for the tumour cell as it is for the normal host cell. Tumour cells and normal host cells constantly interact with each other, and the balance of these interactions results in the prevailing homeostatic
Ng, Wayne, Morokoff, Andrew
core +1 more source