Results 31 to 40 of about 734,316 (316)
Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer
Nature Communications, 2021 The unfolded protein response (UPR) promotes cell survival in cancers with hyperactive ER stress response. Here the authors show that CARM1, an arginine methyltransferase, controls the IRE1α/XBP1 pathway of the UPR and the inhibition of this pathway can ...
Jianhuang Lin +13 more
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Hepatology Communications, 2020 Transforming growth factor β (TGFβ) induces hepatic stellate cell (HSC) differentiation into tumor‐promoting myofibroblast, although underlying mechanism remains incompletely understood.
Yunru Chen +10 more
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Oncogenesis, 2023 Advanced cutaneous melanoma is the deadliest form of skin cancer and one of the most aggressive human cancers. Targeted therapies (TT) against BRAF mutated melanoma and immune checkpoints blockade therapies (ICB) have been a breakthrough in the treatment
Serena Diazzi +2 more
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The Breast Tumor Microenvironment: A Key Player in Metastatic Spread
, 2021 The tumor microenvironment plays a pivotal role in the tumorigenesis, progression, and metastatic spread of many cancers including breast. There is now increasing evidence to support the observations that a bidirectional interplay between breast cancer ...
Barbara E. Nickel +7 more
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Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Signal Transduction and Targeted Therapy, 2023 Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects more than 500 million population worldwide. OA was believed to be caused by the wearing and tearing of articular cartilage, but it is now more commonly ...
Qing Yao +9 more
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The Immune Microenvironment of Malignant Pleural Mesothelioma: A Literature Review
, 2021 Malignant pleural mesothelioma (MPM) is a rare and aggressive tumour with a poor prognosis, associated with asbestos exposure. Nowadays, treatment is based on chemotherapy with a median overall survival of less than two years.
Anne-Laure Désage +3 more
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International Journal of Oral Science, 2022 The progressive destruction of condylar cartilage is a hallmark of the temporomandibular joint (TMJ) osteoarthritis (OA); however, its mechanism is incompletely understood.
Yumei Lai +11 more
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The Role of Indoleamine 2, 3-Dioxygenase 1 in Regulating Tumor Microenvironment
, 2022 SIMPLE SUMMARY: Tumor microenvironment is a complex and dynamically changing entity, which is crucial for tumor development. Indoleamine 2, 3-dioxygenase 1 is elevated in the tumor microenvironment and is strongly associated with tumor histological ...
Xiaobo Wang +7 more
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Metabolic crosstalk between stromal and malignant cells in the bone marrow niche
Bone Reports, 2023 Bone marrow is the primary site of blood cell production in adults and serves as the source of osteoblasts and osteoclasts that maintain bone homeostasis.
Hernán A. Tirado +4 more
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Immune Cells in the Tumor Microenvironment of Soft Tissue Sarcomas
, 2023 Soft tissue sarcomas (STSs) are a rare heterogeneous group of malignant neoplasms characterized by their aggressive course and poor response to treatment. This determines the relevance of research aimed at studying the pathogenesis of STSs. By now, it is
Timur Fatkhudinov +4 more
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