The ambitious role of anti angiogenesis molecules: Turning a cold tumor into a hot one [PDF]
, 2018 In renal cancer emerging treatment options are becoming available and there is a strong need to combine therapies to reformulate and adjourn clinical practice.
Botticelli, A. +4 more
core +1 more source
Extracellular Vesicle-Mediated Communication between the Glioblastoma and Its Microenvironment [PDF]
, 2019 The glioblastoma is the most malignant form of brain cancer. Glioblastoma cells use multiple ways of communication with the tumor microenvironment in order to tune it for their own benefit.
Pastor Loro, Ángel Manuel +1 more
core +1 more source
Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response. [PDF]
, 2019 Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and confers a poor prognosis. Beyond standard systemic therapy with multikinase inhibitors, recent studies demonstrate the potential for robust and durable responses ...
Fong, Lawrence +2 more
core +2 more sources
Nature Communications, 2021 Cancer derived exosomes are reported to promote metastatic dissemination. Here the authors show that cytokines in the tumor microenvironment bind to exosomes via glycosaminoglycan side chains of proteoglycans, and these exosomes are preferentially taken ...
Luize G. Lima +11 more
doaj +1 more source
Metabolic crosstalk between stromal and malignant cells in the bone marrow niche
Bone Reports, 2023 Bone marrow is the primary site of blood cell production in adults and serves as the source of osteoblasts and osteoclasts that maintain bone homeostasis.
Hernán A. Tirado +4 more
doaj +1 more source
Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment. [PDF]
, 2018 The myeloma bone marrow microenvironment promotes proliferation of malignant plasma cells and resistance to therapy. Activation of JAK/STAT signaling is thought to be a central component of these microenvironment-induced phenotypes.
Aftab, Blake T +13 more
core +2 more sources
Tumor microenvironment revisited [PDF]
EMBO reports, 2014 A number of authoritative reviews devoted to the role of the tumor microenvironment have been published in recent years [1], [2]. It is evident that the tumor stroma can modulate many tumor characteristics including the response to therapy. We need to keep this in mind, especially now that there is an increasing tendency to base intervention strategies
Anton, Berns, Pier Paolo, Pandolfi
openaire +2 more sources
Functional characterization of ABCA4 genetic variants related to Stargardt disease
Scientific Reports, 2022 The ATP-binding cassette subfamily 4 (ABCA4), a transporter, is localized within the photoreceptors of the retina, and its genetic variants cause retinal dystrophy. Despite the clinical importance of the ABCA4 transporter, a few studies have investigated
Bo Min Kim +6 more
doaj +1 more source
Investigating prostate cancer tumour-stroma interactions - clinical and biological insights from an evolutionary game [PDF]
, 2011 BACKGROUND: Tumours are made up of a mixed population of different types of cells that include normal structures as well as ones associated with the malignancy, and there are multiple interactions between the malignant cells and the local ...
Alexander R. A. Anderson +5 more
core +3 more sources
Targeting cellular senescence to combat cancer and ageing
Molecular Oncology, 2022 Senescence is a complex cellular process that is implicated in various physiological and pathological processes. It is characterized by a stable state of cell growth arrest and by a secretome of diverse pro‐inflammatory factors, chemokines and growth ...
Chen Wang, Xue Hao, Rugang Zhang
doaj +1 more source