Results 11 to 20 of about 651,999 (266)

Immunosuppressive Microenvironment in Neuroblastoma [PDF]

Frontiers in Oncology, 2013
According to the cancer immunoediting model, the interplay between tumor cells and the host immune system is crucial for the control of tumor growth. NB is a pediatric tumor that presents with metastatic disease at diagnosis in about 50% of the cases, the majority of which have poor prognosis.
Pistoia, Vito, Morandi, Fabio, Bianchi, Giovanna, Pezzolo, Annalisa, Prigione, Ignazia, Raffaghello, Lizzia   +5 more
openaire   +3 more sources

Sensitization of ovarian tumor to immune checkpoint blockade by boosting senescence-associated secretory phenotype

iScience, 2021
Summary: Therapy-induced senescence-associated secretory phenotype (SASP) correlates with overcoming resistance to immune checkpoint blockade (ICB). Intrinsic resistance to ICB is a major clinical challenge.
Xue Hao, Bo Zhao, Wei Zhou, Heng Liu, Takeshi Fukumoto, Dmitry Gabrilovich, Rugang Zhang   +6 more
doaj   +1 more source

Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer

Nature Communications, 2021
The unfolded protein response (UPR) promotes cell survival in cancers with hyperactive ER stress response. Here the authors show that CARM1, an arginine methyltransferase, controls the IRE1α/XBP1 pathway of the UPR and the inhibition of this pathway can ...
Jianhuang Lin, Heng Liu, Takeshi Fukumoto, Joseph Zundell, Qingqing Yan, Chih-Hang Anthony Tang, Shuai Wu, Wei Zhou, Dajiang Guo, Sergey Karakashev, Chih-Chi Andrew Hu, Kavitha Sarma, Andrew V. Kossenkov, Rugang Zhang   +13 more
doaj   +1 more source

Firing up the cold tumors by targeting Vps34

OncoImmunology, 2020
Cancer immunotherapy based on anti-PD-1/PD-L1 blockade is particularly effective in responding to patients with hot tumors. These tumors are characterized by the accumulation of proinflammatory cytokines and T cell infiltration.
Bassam Janji, Meriem Hasmim, Santiago Parpal, Guy Berchem, Muhammad Zaeem Noman   +4 more
doaj   +1 more source

Telocytes in the Tumor Microenvironment

, 2021
There are several theories explaining the communication between cells in the context of tumor development. Over the years, interactions between normal and transformed cells have been observed. Generally, all types of cells make equal contributions to the formation of the tumor microenvironment - a location of primary oncogenesis.
Aleksandrovych, Veronika, Gil, Krzysztof
openaire   +3 more sources

The emerging roles of MAPK-AMPK in ferroptosis regulatory network

Cell Communication and Signaling, 2023
Ferroptosis, a newform of programmed cell death, driven by peroxidative damages of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes and is extremely dependent on iron ions, which is differs characteristics from traditional cell ...
Xinyue Wang, Xiao Tan, Jinping Zhang, Jiaping Wu, Hongjuan Shi   +4 more
doaj   +1 more source

The influence of nanotopography on cell behaviour through interactions with the extracellular matrix – A review

Bioactive Materials, 2022
Nanotopography presents an effective physical approach for biomaterial cell manipulation mediated through material-extracellular matrix interactions.
Jiajun Luo, Matthew Walker, Yinbo Xiao, Hannah Donnelly, Matthew J. Dalby, Manuel Salmeron-Sanchez   +5 more
doaj   +1 more source

The mechanical phenotypic plasticity of melanoma cell: an emerging driver of therapy cross-resistance

Oncogenesis, 2023
Advanced cutaneous melanoma is the deadliest form of skin cancer and one of the most aggressive human cancers. Targeted therapies (TT) against BRAF mutated melanoma and immune checkpoints blockade therapies (ICB) have been a breakthrough in the treatment
Serena Diazzi, Sophie Tartare-Deckert, Marcel Deckert   +2 more
doaj   +1 more source

Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Signal Transduction and Targeted Therapy, 2023
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects more than 500 million population worldwide. OA was believed to be caused by the wearing and tearing of articular cartilage, but it is now more commonly ...
Qing Yao, Xiaohao Wu, Chu Tao, Weiyuan Gong, Mingjue Chen, Minghao Qu, Yiming Zhong, Tailin He, Sheng Chen, Guozhi Xiao   +9 more
doaj   +1 more source

Focal Adhesion Kinase Promotes Hepatic Stellate Cell Activation by Regulating Plasma Membrane Localization of TGFβ Receptor 2

Hepatology Communications, 2020
Transforming growth factor β (TGFβ) induces hepatic stellate cell (HSC) differentiation into tumor‐promoting myofibroblast, although underlying mechanism remains incompletely understood.
Yunru Chen, Qing Li, Kangsheng Tu, Yuanguo Wang, Xianghu Wang, Dandan Liu, Chen Chen, Donglian Liu, Rendong Yang, Wei Qiu, Ningling Kang   +10 more
doaj   +1 more source