Results 71 to 80 of about 16,394 (180)

Tetratricopeptide repeat domain 9A is an interacting protein for tropomyosin Tm5NM-1

BMC Cancer, 2008
Background Tetratricopeptide repeat domain 9A (TTC9A) protein is a recently identified protein which contains three tetratricopeptide repeats (TPRs) on its C-terminus.
Ho Gay, Cao Shenglan, Lin Valerie CL
doaj   +1 more source

Deep Mutational Scanning for the Study and Engineering of Protein Assemblies

Chemistry–Methods, Volume 6, Issue 8, August 2026.
This review explores how deep mutational scanning (DMS) can be used to improve understanding and accelerate engineering of protein assemblies, from natural fibers to engineered nanocages. We discuss various types of protein assemblies and their characterization, provide an introduction to the DMS technique, and then highlight examples in which DMS has ...
Jenna B. Wolfanger, Shoili Banerjee, Carolyn E. Mills   +2 more
wiley   +1 more source

Altered lipid homeostasis in Sertoli cells stressed by mild hyperthermia.

PLoS ONE, 2014
Spermatogenesis is known to be vulnerable to temperature. Exposures of rat testis to moderate hyperthermia result in loss of germ cells with survival of Sertoli cells (SC). Because SC provide structural and metabolic support to germ cells, our aim was to
Ana S Vallés, Marta I Aveldaño, Natalia E Furland   +2 more
doaj   +1 more source

Heat Stress Triggers Nuclear Invagination and Spatial Compartmentalization of Protein Metabolism

Cell Proliferation, Volume 59, Issue 8, August 2026.
Cells adapt heat stress to shape a nuclear invagination region function as “protein metabolism hotspots”, where both protein production and degradation are enhanced. ABSTRACT Heat stress is a common challenge for cells, causing multiple types of cellular damage while triggering complex stress responses, including the highly conserved mechanism known as
Zhi‐Hao Zhang, Yuan‐Tao Qiu, Jing‐Yue Cao, Yi‐Feng Huang, Ye‐Lin Lan, Yu‐Li Zhao, Fu Wu, Chen‐Long Wang, Guo‐Run Tang, Jing‐Yun Ji, Zhang Zhang, Guan‐Zheng Luo   +11 more
wiley   +1 more source

El citoesqueleto de actina: una perspectiva desde la biología molecular del cáncer

Revista Cubana de Investigaciones Biomédicas, 2002
Se realizó una síntesis de los temas que emergen en la actualidad sobre la estructura y organización del citoesqueleto de actina y las vías de señalización que participan en su regulación.
Otmara Guirado Blanco, Montserrat Solanas García, Irmgard Costa Traschel, Eduard Escrich Escriche   +3 more
doaj  

Desmosomal Molecules In and Out of Adhering Junctions: Normal and Diseased States of Epidermal, Cardiac and Mesenchymally Derived Cells

Dermatology Research and Practice, 2010
Current cell biology textbooks mention only two kinds of cell-to-cell adhering junctions coated with the cytoplasmic plaques: the desmosomes (maculae adhaerentes), anchoring intermediate-sized filaments (IFs), and the actin microfilament-anchoring ...
Sebastian Pieperhoff, Mareike Barth, Steffen Rickelt, Werner W. Franke   +3 more
doaj   +1 more source

Phosphate and acidosis cause fibre type‐specific changes to cellular and molecular contractile mechanics at 37°C in skeletal muscle from older adults

Experimental Physiology, Volume 111, Issue 8, Page 3753-3771, 1 August 2026.
Abstract Intracellular accumulation of hydrogen ions (H+) and inorganic phosphate (Pi) has temperature‐dependent effects on single‐fibre contractile function between 10°C and 30°C. In vivo, human skeletal muscle temperatures range between 35‐39°C, and although contractile function is highly dependent on temperature, the effects of fatigue‐inducing [H+]
Brent A. Momb, Jane A. Kent, Stuart R. Chipkin, Mark S. Miller   +3 more
wiley   +1 more source

Reorganization of the actin cytoskeleton during the formation of neutrophil extracellular traps (NETs)

European Journal of Cell Biology
We analyzed actin cytoskeleton alterations during NET extrusion by neutrophil-like dHL-60 cells and human neutrophils in the absence of DNase1 containing serum to avoid chromatin degradation and microfilament disassembly.
Hans Georg Mannherz, Heidi Budde, Muhammad Jarkas, Roua Hassoun, Natalia Malek-Chudzik, Antonina J. Mazur, Jelena Skuljec, Refik Pul, Markus Napirei, Nazha Hamdani   +9 more
doaj   +1 more source

Perfluorooctanesulfonate (PFOS)-induced Sertoli cell injury through a disruption of F-actin and microtubule organization is mediated by Akt1/2

Scientific Reports, 2017
PFOS (perfluorooctanesulfonate, or perfluorooctane sulfonic acid) is an anthropogenic fluorosurfactant widely used in consumer products. While its use in Europe, Canada and the U.S.
Ying Gao, Haiqi Chen, Xiang Xiao, Wing-yee Lui, Will M. Lee, Dolores D. Mruk, C. Yan Cheng   +6 more
doaj   +1 more source

Monocytic cells become less compressible but more deformable upon activation.

PLoS ONE, 2014
AimsMonocytes play a significant role in the development of atherosclerosis. During the process of inflammation, circulating monocytes become activated in the blood stream.
Agnese Ravetto, Hans M Wyss, Patrick D Anderson, Jaap M J den Toonder, Carlijn V C Bouten   +4 more
doaj   +1 more source