Results 141 to 150 of about 174,983 (281)

Role of Protein Kinase C in Microglia-induced Neurotoxicity in Mesencephalic Cultures [PDF]

open access: bronze, 1997
Michael McMillian   +2 more
openalex   +1 more source

Bridging Mechanical Properties with Atomic Structures of Polymorphic α‐Synuclein Fibrils by Single‐Molecule Analysis and Molecular Dynamics Simulations

open access: yesAggregate, EarlyView.
α‐Synuclein fibrils exhibit distinct mechanical properties influencing their neurotoxicity and pathogenicity in synucleinopathies like Parkinson's disease. Combining optical tweezers and molecular dynamics simulations, this study builds the structure–mechanics relationships of wild‐type and two disease‐associated mutants E46K and A53T α‐Synuclein ...
Lulu Bi   +9 more
wiley   +1 more source

A Novel Mixed Convolution Transformer Model for the Fast and Accurate Diagnosis of Glioma Subtypes

open access: yesAdvanced Intelligent Systems, EarlyView.
The mixed convolutional transformer model represents a novel approach for the accurate and rapid diagnosis of glioma subtypes. This model employs advanced, complex layers and functions, establishing its uniqueness and enhancing its ability to deliver precise outcomes in glioma subtype detection.
S. M. Nuruzzaman Nobel   +7 more
wiley   +1 more source

Cytokine Induction of MIP-1α and MIP-1β in Human Fetal Microglia [PDF]

open access: bronze, 1998
Carrie M. McManus   +2 more
openalex   +1 more source

Expanding the Tyrosine Kinase Domain of CSF1R? A Case Report From an Adult‐Onset Leukoencephalopathy

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Adult‐onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), also termed hereditary diffuse leukoencephalopathy with spheroids‐1 (HDLS1), results from mutations in the CSF1R gene and leads to progressive leukoencephalopathy.
Piervito Lopriore   +11 more
wiley   +1 more source

A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force

open access: yesEpilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica   +6 more
wiley   +1 more source

Allogenic microglia replacement: A novel therapeutic strategy for neurological disorders

open access: yesFundamental Research
Microglia are resident immune cells in the central nervous system (CNS) that play vital roles in CNS development, homeostasis and disease pathogenesis.
Yanxia Rao, Bo Peng
doaj  

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