Results 151 to 160 of about 388,044 (340)

Neuroimmune Microenvironment Reprogramming via Immuno‐piezoelectric Transducers for Synergistic Stem Cell Therapy in Traumatic Brain Injury

Advanced Materials, EarlyView.
A novel immuno‐piezoelectric transducer is innovatively developed. This device promotes neural stem cell (NSC) differentiation and maturation via ultrasound‐induced electrical stimulation and it amplifies the therapeutic efficacy of NSC in traumatic brain injury (TBI) by modulating the immune microenvironment. This piezoelectric transducer with “immune‐
Linlin Liang, Xin Li, Kai Hu, Pingqiang Cai, Jianwu Wang, Jing Yu, Shasha Wang, Yuwei Zhao, Changgeng Xu, Siwei Li, Hong Liu, Changyong Wang, Jin Zhou   +12 more
wiley   +1 more source

Allogenic microglia replacement: A novel therapeutic strategy for neurological disorders

Fundamental Research
Microglia are resident immune cells in the central nervous system (CNS) that play vital roles in CNS development, homeostasis and disease pathogenesis.
Yanxia Rao, Bo Peng
doaj   +1 more source

Microglia Heterogeneity: A Single-cell Concerto

, 2022
Leilei Wang, Haoran Wu, Shanshan Zhang, Dingxian He, Yi Chen, Jingxin Xue, Linya You, Qiong Liu, Wensheng Li   +8 more
openalex   +2 more sources

Lithium‐Charged Gold Nanoparticles: A New Powerful Tool for Lithium Delivery and Modulation of Glycogen Synthase Kinase 3 Activity

Advanced Materials, EarlyView.
This study introduces glutathione‐stabilized gold nanoparticles for targeted lithium delivery (LiG‐AuNPs), enabling the controlled modulation of Glycogen Synthase Kinase‐3 (GSK‐3β). These non‐toxic, 2‐nm particles release lithium intracellularly, effectively inhibiting GSK‐3β in the brain without significant plasma lithium alterations.
Antonio Buonerba, Giulia Puliatti, Domenica Donatella Li Puma, Bruno Bandiera, Beatrice Cannata, Maria Elena Marcocci, Nicolina Castagno, Irene Contento, Salvatore Impemba, Mariarosa Scognamiglio, Rocco Di Girolamo, Vincenzo Naddeo, Patrizia Canton, Carmine Capacchione, Laura Sposito, Martina Albini, Francesco Pastore, Silvia Baroni, Alfonso Grassi, Claudio Grassi, Roberto Piacentini   +20 more
wiley   +1 more source

The Neuroimmunological Nexus of Multiple Sclerosis: Deciphering the Microglial Transcriptomic Tapestry

Neuroglia
Microglia are poorly understood immune cells of the central nervous system that play a determining role in the progression of multiple sclerosis. With the advent of genomic techniques such as single-cell RNA sequencing and single-nucleus RNA sequencing ...
Akanksha Jha, Hemant Kumar
doaj   +1 more source

The impact of metallothionein-II on microglial response to tumor necrosis factor-alpha (TNFα) and downstream effects on neuronal regeneration

Journal of Neuroinflammation, 2018
Background The extracellular environment plays an important role in supporting the regeneration of axons after injury. Metallothionein-II (MTII) is a metal-binding protein known for its neuroprotective effect by directly stimulating the growth of axons ...
Jacqueline Y. K. Leung, William R. Bennett, Anna E. King, Roger S. Chung   +3 more
doaj   +1 more source

Macrophages Mediate Mesoscale Brain Mechanical Homeostasis

Advanced Materials, EarlyView.
We investigated the role of infiltrating immune cells in sculpting the developing brain. Using Brillouin microscopy and active microrheology, we found microglia actively maintain tissue viscoelasticity. Moreover, colony stimulating factor one receptor (CSF1R)‐driven stromal remodeling alters brain mechanics in vivo. These findings link immune activity,
Woong Young So, Bailey Johnson, Patricia B. Gordon, Kevin S. Bishop, Hyeyeon Gong, Hannah A Burr, Jack Rory Staunton, Chenchen Handler, Khanh Loan Ly, Raman Sood, Giuliano Scarcelli, Kandice Tanner   +11 more
wiley   +1 more source

Neuraminidase-activated microglia compromise the viability of ependymocytes [PDF]

, 2017
Neuraminidase (NA) is a sialidase present in the envelope/wall of some virus/bacteria responsible for brain infections, such as flu, mumps or meningitis. The intracerebroventricular injection of NA in the rat brain provokes ependymal detachment and death,
Carrillo-Pinzon, Cristobal, Fernandez-Arjona, Mar, Fernández-Llebrez, Pedro, Grondona, Jesús M, López-Ávalos, María Dolores   +4 more
core  

Piezoelectric Stimulation of Neural Cells: Exploring the Synergistic Potential of Hybrid Scaffolds for Enhanced Regeneration

Advanced Materials Interfaces, EarlyView.
Hybrid piezoelectric scaffolds offer a promising route for Central Nervous System regeneration by combining structural and electrical cues to support neural stem cell growth. This review highlights their potential to overcome current challenges in neural tissue engineering by exploring porous hybrid materials, their biological interactions, and ...
Heather F. Titterton, Chris R. Bowen, Hamideh Khanbareh   +2 more
wiley   +1 more source

Glioblastoma drives protease-independent extracellular matrix invasion of microglia

Materials Today Bio
Glioblastoma (GBM) is the most common and lethal form of primary brain cancer. Microglia infiltration into the tumor microenvironment is associated with immunosuppression and poor prognosis.
Chia-Wen Chang, Ashwin Bale, Rohit Bhargava, Brendan A.C. Harley   +3 more
doaj   +1 more source