Results 151 to 160 of about 174,983 (281)

A Transcriptome‐Wide Mendelian Randomization Study in Isolated Human Immune Cells Highlights Risk Genes Involved in Viral Infections and Potential Drug Repurposing Opportunities for Schizophrenia

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Schizophrenia is a neurodevelopmental psychiatric disorder characterized by symptoms of psychosis, thought disorder, and flattened affect. Immune mechanisms are associated with schizophrenia, though the precise nature of this relationship (causal, correlated, consequential) and the mechanisms involved are not fully understood.
David Stacey, Liam Gaziano, Preethi Eldi, Catherine Toben, Beben Benyamin, S. Hong Lee, Elina Hyppönen   +6 more
wiley   +1 more source

A companion to the preclinical common data elements and case report forms for in vivo rodent neuroimaging: A report of the TASK3‐WG3 Neuroimaging Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Erwin A. van Vliet, Riikka Immonen, Ofer Prager, Alon Friedman, Jens P. Bankstahl, David K. Wright, Terence J. O'Brien, Heidrun Potschka, Olli Gröhn, Neil G. Harris   +9 more
wiley   +1 more source

Differential suppression of interferon-γ-induced Ia antigen expression on cultured rat astroglia and microglia by second messengers

, 1990
A. Sasaki, S.W. Levison, J.P.-Y. Ting
openalex   +2 more sources

Microglia Express CCR5, CXCR4, and CCR3, but of These, CCR5 Is the Principal Coreceptor for Human Immunodeficiency Virus Type 1 Dementia Isolates [PDF]

, 1999
Andrew Albright, Joseph T.C. Shieh, Takayuki Itoh, Benhur Lee, David Pleasure, Michael J. O’Connor, Robert W. Doms, Francisco González‐Scarano   +7 more
openalex   +1 more source

Subretinal microglia support donor photoreceptor survival in rd1 mice

Stem Cell Research & Therapy
Purpose To investigate the potential relationship between subretinal microglia and transplanted donor photoreceptors. Methods Photoreceptor precursors were transplanted into wild-type mice and rd1 mice by trans-scleral injection. Immunohistochemistry was
Qinjia Ren, Fang Lu, Ruwa Hao, Yingying Chen, Chen Liang   +4 more
doaj   +1 more source

Microglia reaction on the neurotoxic effect of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) in the nigrostriatal pathway in mice

, 1994
Anna Członkowska, Małgorzata Kohutnicka, I. Kurkowska-Jastreȩbska, Andrzej Członkowski   +3 more
openalex   +1 more source

Microglial ApoD‐induced NLRC4 inflammasome activation promotes Alzheimer's disease progression

Animal Models and Experimental Medicine, EarlyView.
We found that NLRC4 inflammasome was activated in microglia releasing IL6 and TNF‐α to impair the hippocampal neural stem cells (NSCs) self‐proliferation. ApoD contributed to activating NLRC4 inflammasome in microglia. Targeting the ApoD provides beneficial effects on NSCs self‐proliferation and mature neurons survival.
Yaliang Yu, Jianzhou Lv, Dan Ma, Ya Han, Yaheng Zhang, Shanlong Wang, Zhitao Wang   +6 more
wiley   +1 more source

Exploring the co‐morbid relationship between Alzheimer's disease and lung cancer in the 5xFAD transgenic mouse model

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of inverse comorbidities of Alzheimer's disease and lung cancer. Abstract Background Alzheimer's disease (AD) and lung cancer are leading causes of mortality among the older population. Epidemiological evidence suggests an antagonistic relationship between them, whereby patients with AD exhibit a reduced risk of developing cancer and ...
Mingfeng Li, Xinghan Wu, Lin Jiang, Min Liu, Gong Yanju, Xiaomeng Li, Fan Tian, Fan Ye, Jinlong Wang, Siyuan Wang, Chuan Qin, Ling Zhang   +11 more
wiley   +1 more source

Phosphatidylserine-dependent phagocytosis of apoptotic glioma cells by normal human microglia, astrocytes, and glioma cells [PDF]

, 2000
Grace H.-F. Chang, Nicholas M. Barbaro, Russell O. Pieper   +2 more
openalex   +2 more sources

Effect of in vivo reprogramming of astrocytes combined with exercise training on neurorepair in rats with spinal cord injury

Animal Models and Experimental Medicine, EarlyView.
Exercise and astrocyte reprogramming synergize to enhance motor function and reduce glial scarring after spinal cord injury, with combined therapies surpassing individual effects. Abstract Background The inability of damaged neurons to regenerate and of axons to establish new functional connections leads to permanent functional deficits after spinal ...
Zuliyaer Talifu, Xin Xu, Huayong Du, Zehui Li, Xiaoxin Wang, Chunjia Zhang, Yunzhu Pan, Han Ke, Wubo Liu, Feng Gao, Degang Yang, Yingli Jing, Yan Yu, Liangjie Du, Jianjun Li   +14 more
wiley   +1 more source