Results 151 to 160 of about 242,823 (354)

Comprehensive Characterization of the Immune Microenvironment Based on Nested Resampling Machine Learning Framework Identifies TRAF3 Interacting Protein 3 as a Promising Regulator to Improve the Resistance to Immunotherapy in Glioma

Advanced Science, EarlyView.
This study develops a nested resampling machine learning framework to establish the Immune Glioma Survival Signature (IGLoS), which stratifies glioma patients and predicts immunotherapy resistance. Multi‐omics analyses reveal TRAF3IP3 as a pivotal regulator of PD‐L1 expression and T‐cell exhaustion via ERK‐NFATC2 signaling.
Yanbo Yang, Fei Wang, Yulian Zhang, Run Huang, Chuanpeng Zhang, Lu Zhao, Hanhan Dang, Xinyu Tao, Yue Lu, Dengfeng Lu, Yunsheng Zhang, Kun He, Jiancong Weng, Zhouqing Chen, Zhong Wang, Yanbing Yu   +15 more
wiley   +1 more source

The Role of Microglia in Perioperative Pain and Pain Treatment: Recent Advances in Research

Journal of Integrative Neuroscience
Microglia play a crucial role in monitoring the microenvironment of the central nervous system. Over the past decade, the role of microglia in the field of pain has gradually been unraveled.
Shengnan Shi, Xingrui Gong
doaj   +1 more source

Comparison and quantitation of Ia antigen expression on cultured macroglia and ameboid microglia from Lewis rat cerebral cortex: analyses and implications

, 1989
Atsushi Sasaki, Steven W. Levison, Jenny P.‐Y. Ting   +2 more
openalex   +2 more sources

Radiation Exposure Induced Blood–Brain Barrier Injury via Mitochondria‐Mediated Sterile Inflammation

Advanced Science, EarlyView.
This work describes a blood–brain barrier (BBB) microphysiological system (MPS) to explore the responses of BBB to radiation exposure. Following radiation exposure, obvious BBB comprise and brain endothelial injuries are detected. Mechanism study shows radiation induced significant sterile inflammation via mitochondrial dysfunction and cGAS‐STING ...
Peng Wang, Jiayue Liu, Min Zhang, Juan Yang, Peihan Lian, Xiu Cheng, Jianhua Qin   +6 more
wiley   +1 more source

Subretinal microglia support donor photoreceptor survival in rd1 mice

Stem Cell Research & Therapy
Purpose To investigate the potential relationship between subretinal microglia and transplanted donor photoreceptors. Methods Photoreceptor precursors were transplanted into wild-type mice and rd1 mice by trans-scleral injection. Immunohistochemistry was
Qinjia Ren, Fang Lu, Ruwa Hao, Yingying Chen, Chen Liang   +4 more
doaj   +1 more source

Activation of p38^MAPK in Microglia After Ischemia [PDF]

, 1998
Kevin M. Walton, Richard J. DiRocco, Becky A. Bartlett, Elizabeth J. Koury, Val R. Marcy, Bruce W. Jarvis, Erik Schaefer, Ratan V. Bhat   +7 more
openalex   +1 more source

H2O2‐Activated Serotonin Precursor Probe for Mapping Neuronal Redox Homeostasis Reveals 5‐HT Interactions with Neighboring Proteins Under Oxidative Stress

Advanced Science, EarlyView.
HOP, an innovative ICT‐based fluorescent probe, visualizes H2O2 in stressed neurons while locally releasing serotonin (5‐HT) for real‐time protein interaction mapping. Its unique tandem sensing and labeling strategy reveals 5‐HT's role under oxidative stress, offering a powerful tool for neurophysiological research and therapeutic discovery.
Yani Liu, Jiwen Yuan, Tuanjie Zhang, Xinyi Cai, Meng Xu, Xueao Wang, Rui Wang, Bing Zhang, Hai‐Liang Zhu, Yong Qian   +9 more
wiley   +1 more source

Proliferation of microglia in the injured cerebral cortex of mice as studied by thiamine pyrophosphatase histochemistry combined with 3H-thymidine autoradiography.

, 1991
Toshihiko Miyake, Tadahisa Kitamura
openalex   +2 more sources

Cytokine Induction of MIP-1α and MIP-1β in Human Fetal Microglia [PDF]

, 1998
Carrie M. McManus, Celia F. Brosnan, Joan W. Berman   +2 more
openalex   +1 more source

Neurotoxic reactive astrocytes are induced by activated microglia

Nature, 2017
S. A. Liddelow, Kevin A. Guttenplan, Laura E. Clarke, F. C. Bennett, Christopher J. Bohlen, Lucas Schirmer, Mariko L Bennett, Alexandra E. Münch, Won-Suk Chung, Todd C. Peterson, D. Wilton, A. Frouin, Brooke A. Napier, Nikhil Panicker, Manoj Kumar, M. Buckwalter, D. Rowitch, V. Dawson, Ted M. Dawson, Beth Stevens, B. Barres   +20 more
semanticscholar   +1 more source