Results 181 to 190 of about 174,983 (281)

Reactive microglia are the major source of tumor necrosis factor alpha and contribute to astrocyte dysfunction and acute seizures in experimental temporal lobe epilepsy

Glia, Volume 71, Issue 2, Page 168-186, February 2023., 2023
Main Points Microglia become rapidly reactive in temporal lobe epilepsy (TLE). Microglia are major producers of TNFα during status epilepticus, which impairs astrocyte coupling and promotes gliosis. Depletion of microglia attenuates acute seizure activity in TLE.
Lukas Henning, Henrike Antony, Annika Breuer, Julia Müller, Gerald Seifert, Etienne Audinat, Parmveer Singh, Frederic Brosseron, Michael T. Heneka, Christian Steinhäuser, Peter Bedner   +10 more
wiley   +1 more source

Single-Nucleus RNA Sequencing Reveals Enduring Signatures of Acute Stress and Chronic Exercise in Striatal Microglia. [PDF]

Genes Brain Behav
Connolly MG, Johnson ZV, Chu L, Johnson ND, Buhr TJ, McNeill EM, Clark PJ, Rhodes JS.   +7 more
europepmc   +1 more source

Stereological analysis of astrocyte and microglia in aging mouse hippocampus

, 1998
Jeffrey M. Long, Audrey N. Kalehua, Nancy J. Muth, Michael E. Calhoun, Mathias Jucker, John Hengemihle, Donald K. Ingram, Peter R. Mouton   +7 more
openalex   +1 more source

Effects of Incorporation of Immunoglobulin G and Complement Component C1q on Uptake and Degradation of Alzheimer's Disease Amyloid Fibrils by Microglia [PDF]

, 2000
Melanie Brazil, Haeyong Chung, Frederick R. Maxfield   +2 more
openalex   +1 more source

Mapping Molecular Pathways of Multiple Sclerosis: A Gene Prioritization and Network Analysis of White Matter Pathology Transcriptomics

Annals of Neurology, EarlyView.
Objectives Rapid advances in transcriptomics have driven efforts to identify deregulated pathways in multiple sclerosis (MS) tissues, though many detected differentially expressed genes are likely false positives, with only a small fraction reflecting actual pathological events. Robust, integrative methods are essential for accurately understanding the
Gianmarco Abbadessa, Ai Nagano, Simon Hametner, Owain Howell, David Owen, Artemis Papadaki, Prashant Srivastava, Simona Bonavita, Roberta Magliozzi, Richard Reynolds, Mie Rizig, Richard Nicholas   +11 more
wiley   +1 more source

Loss of oligodendrocyte ErbB receptor signaling leads to hypomyelination, reduced density of parvalbumin‐expressing interneurons, and inhibitory function in the auditory cortex

Glia, Volume 71, Issue 2, Page 187-204, February 2023., 2023
Main Point Loss of oligodendrocyte ErbB receptor signaling leads to A1 hypomyelination, reduced PV expression and density of PV+ neurons and synapses, hypoconnectivity of inhibitory circuits and shift of the E/I balance towards excitation. Abstract For a long time, myelin was thought to be restricted to excitatory neurons, and studies on dysmyelination
Beatriz C. Borges, Xiangying Meng, Patrick Long, Patrick O. Kanold, Gabriel Corfas   +4 more
wiley   +1 more source

Decoding microglial immunometabolism: a new frontier in Alzheimer's disease research. [PDF]

Mol Neurodegener
Jung ES, Choi H, Mook-Jung I.
europepmc   +1 more source

Abundant Defective Viral Particles Budding from Microglia in the Course of Retroviral Spongiform Encephalopathy [PDF]

, 2000
Regine Hansen, Stefanie Czub, Evi Werder, Jens Herold, Georg Gosztonyi, Hans Gelderblom, Simone Schimmer, Stefan Mazgareanu, Volker ter Meulen, Markus Czub   +9 more
openalex   +1 more source

Association of Synovial Innate Immune Exhaustion With Worse Pain in Knee Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective Uncontrolled pain remains a major clinical challenge in the management of knee osteoarthritis (OA), the most common disabling joint disease. Worse pain is associated with synovial innate immune cell infiltration (synovitis), but the role of innate immune‐regulatory cells in pain is unknown. Our objective was to identify synovial innate immune
Holly T. Philpott, Trevor B. Birmingham, Garth Blackler, J. Daniel Klapak, Alexander J. Knights, Easton C. Farrell, Benoit Fiset, Logan A. Walsh, J. Robert Giffin, Edward M. Vasarhelyi, Steven J. MacDonald, Brent A. Lanting, Tristan Maerz, C. Thomas Appleton, on behalf of the WOREO Knee Study Group   +14 more
wiley   +1 more source

Defining the pig microglial transcriptome reveals its core signature, regional heterogeneity, and similarity with human and rodent microglia

Glia, Volume 71, Issue 2, Page 334-349, February 2023., 2023
Main Points Defined a pig microglial transcriptome signature comprising 239 genes. Demonstrated regional variance in the pig microglial transcriptome across the brain. Revealed similarity of pig microglial gene expression to that of human and mouse microglia.
Barbara B. Shih, Sarah M. Brown, Jack Barrington, Lucas Lefevre, Neil A. Mabbott, Josef Priller, Gerard Thompson, Alistair B. Lawrence, Barry W. McColl   +8 more
wiley   +1 more source