Results 221 to 230 of about 334,601 (325)

S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning

Advanced Science, EarlyView.
Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu, Penglei Wang, Gaoyuan Xu, Jitao Lu, Qinke Peng, Danyang Wu, Hequan Sun   +6 more
wiley   +1 more source

Microglial interferon signaling and Aβ plaque pathology are enhanced in female 5xFAD Alzheimer's disease mice, independent of estrous cycle stage. [PDF]

J Neuroinflammation
Calcines-Rodríguez L, Noyes-Martel N, Becker JL, Nguyen SK, Osabutey MA, Trojanczyk LA, Majewska AK, O'Banion MK.   +7 more
europepmc   +1 more source

Metabolites-Mitochondria-Microglia (Mmma): Therapeutic Stategy for Treatment of Neural Inflammation and Neurodegeneration

, 2018
C. Angelini, Arianna Di Stadio
openalex   +1 more source

Modulation of morphological changes of microglia and neuroprotection by monocyte chemoattractant protein-1 in experimental glaucoma [PDF]

, 2010
Kin Chiu, Sze‐Chun Yeung, Kwok‐Fai So, Raymond Chuen‐Chung Chang   +3 more
openalex   +1 more source

Neuroprotective Effects of Time‐Restricted Feeding Combined With Different Protein Sources in MPTP‐Induced Parkinson's Disease Mice Model and Its Modulatory Impact on Gut Microbiota Metabolism

Advanced Science, EarlyView.
Time‐restricted feeding (TRF) exerts protein‐dependent neuroprotective effects in an MPTP‐induced Parkinson's disease model. In casein‐fed mice, TRF improves gut barrier integrity and reduces neuroinflammation, possibly via modulation of Allobaculum and BCAAs.
Ting Li, Jian Wu, Sheng‐Yang Zhou, Ming‐An Li, Li‐Ping Zhao, Ao Wang, Yi‐Zhi Song, Wen‐Yan Huang, Lu‐Lu Tan, Chen‐Meng Qiao, Wei‐Jiang Zhao, Chun Cui, Yan‐Qin Shen   +12 more
wiley   +1 more source

Microglia, Astrocytes, and Oligodendrocytes in Parkinson's Disease: Neuroinflammatory Crosstalk and Emerging Therapeutic Strategies. [PDF]

Biomolecules
Kędzia D, Galita G, Majsterek I, Rozpędek-Kamińska W.   +3 more
europepmc   +1 more source

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

Advanced Science, EarlyView.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue   +6 more
wiley   +1 more source

Quantitative and morphological analyses reveal microglia-specific neuroinflammation in brain regions linked to cognitive function in ovariectomized and chronic intermittent hypoxia-exposed female rats. [PDF]

Brain Behav Immun Health
Appiah CB, Kunwar K, Cunningham RL, Cunningham JT.   +3 more
europepmc   +1 more source

Antagonizing peroxisome proliferator‐activated receptor γ facilitates M1‐to‐M2 shift of microglia by enhancing autophagy via the LKB1–AMPK signaling pathway

, 2018
Juan Ji, Tengfei Xue, Xudong Guo, Jin Yang, Ruo‐Bing Guo, Juan Wang, Ji‐Ye Huang, Xiao‐Jie Zhao, Xiu‐Lan Sun   +8 more
openalex   +1 more source

The THIK and Thin of Microglia Dynamics [PDF]

, 2018
Jennifer Shih, Chris G. Dulla
openalex   +1 more source