Results 221 to 230 of about 388,044 (340)

Metabolic reprogramming and altered ATP content impair neuroprotective functions of microglia in β-glucocerebrosidase deficiency models. [PDF]

J Neuroinflammation
Brunialti E, Villa A, Szego EM, La Vitola P, Drago D, Pavlovic R, Fontana L, Tuna D, Panzeri A, Meda C, Weissleder C, Rondinone O, Pitasi M, Miozzo M, Deleidi M, Andolfo A, Di Monte DA, Ciana P.   +17 more
europepmc   +1 more source

Transcriptional programs of microglia for integrating brain and peripheral stress responses

, 2022
Masayuki Taniguchi, Tomoyuki Furuyashiki
openalex   +2 more sources

Refractory Status Epilepticus and Therapeutic Uncertainties: a Comprehensive Review on Targeting Neuroinflammation and Rationale for Developing a Platform Trial

Advanced Science, EarlyView.
Refractory status epilepticus (RSE) is a life‐threatening neurological emergency with high rates of death and long‐term disability, but treatments for it are often based on limited evidence. RSE is now understood to involve neuroinflammation, which has led to the exploration of anti‐inflammatory and immunomodulatory agents like Tocilizumab. Traditional
Shanika Samarasekera, Suneesh Thilak, Asha Patel, Prashant Nasa, Zubair Ahmed, Lorraine Jacques, William J. Scotton, Cyril Chacko, Randeep Mullhi, Ruoling Chen, Vikram Patil, Suresh Renukappa, Tonny Veenith   +12 more
wiley   +1 more source

FOXA2 regulated by HDAC3-mediated deacetylation attenuates neuropathic pain by modulating microglial lipid metabolism and synaptic pruning dysregulation. [PDF]

J Neuroinflammation
Zeng H, Wang B, Huang Z, Gao L, Xiao Y, Liu X, Xu Y, Hu Z, Pang J, Yu Y, Guo Y, Wu W.   +11 more
europepmc   +1 more source

Lidocaine Potentiates SOCS3 to Attenuate Inflammation in Microglia and Suppress Neuropathic Pain

, 2019
Yan Zheng, Xuhui Hou, Songbai Yang
openalex   +2 more sources

Bone marrow mesenchymal stem cell transplantation downregulates plasma level and the microglia expression of transforming growth factor β1 in the acute phase of cerebral cortex ischemia

, 2020
Zhaohui Liang, Jian‐Juan Gu, Wenxiu Yu, Yunqian Guan, Mostafa Khater, Xiaobo Li   +5 more
openalex   +1 more source

TRIM56 Aggravates Cerebral Ischemia‐Reperfusion Injury via Inhibiting KLF4‐Activated Ferroptosis Signaling

Advanced Science, EarlyView.
This study reveals that the E3 ubiquitin ligase TRIM56 exacerbates neuronal ferroptosis and brain damage by mediating K48‐linked ubiquitination and degradation of KLF4, leading to suppression of the xCT/GSH/GPX4 axis. Targeting TRIM56 alleviates cerebral ischemia‐reperfusion injury in vivo and in vitro, highlighting its therapeutic potential.
Qiangping Wang, Shuang Li, Man Li, Wenke Zhou, Jianqing Zhang, Zhenfu Wu, Zhaoqi Mao, Juan Wan, Xinhao Tang, Baoping Zheng, Qiang Liu, Zhendong Li, Xiaobing Jiang, Qingping Wu, Youfan Ye, Haijun Wang   +15 more
wiley   +1 more source

Microglia-Mediated Phagocytosis in Alzheimer's Disease: Mechanisms, Heterogeneity, and Therapeutic Insights. [PDF]

Biomolecules
Hassan H, Rawlinson C, Lan YL, Jenkins S, Chen R.   +4 more
europepmc   +1 more source

EARLY PATHOLOGICAL CHANGES IN ALZHEIMER’S DISEASE MEDIATED BY ABERRANT MICROGLIA ACTIVITY

, 2023
Marion Kadlecová, Henriette Haukedal, Abinaya Chandrasekaran, Martin R. Larsen, Kristine Freude   +4 more
openalex   +1 more source

Advanced Stem Cell Therapy: 3D‐Bioprinted Brain‐Like Transplants for Alzheimer's Disease‐Like Dementia

Advanced Science, EarlyView.
A tri‐component biomimetic bioink(gelatin/alginate/fibrinogen) is developed to protect cells in critical pathological environments in AD. Using this bioink, a 3D‐printed NPC construct optimized for hippocampal transplantation is provided to improve cell retention and differentiation in an AD‐like model. This approach enhances memory recovery and offers
Ke Gai, Yu Song, Dawen Gao, Qingning Nie, Xiao Luo, Caizhe Xu, Changhao Cai, Austin Smith, Xiang Li, Wei Shi, Lei Zhang, Wei Sun, Feng Lin   +12 more
wiley   +1 more source