Results 221 to 230 of about 174,983 (281)

Xixin Decoction May Treat Vascular Dementia by Modulating the NPTX2/C1q/C3 Complement Pathway

Chemistry &Biodiversity, EarlyView.
To establish a VaD model, SD rats underwent unilateral common carotid artery ligation, followed by gavage treatment with Xixin decoction. Cognitive abilities of the rats were assessed through Morris water maze and new object recognition. Pathological changes were observed using electron microscopy observation, Golgi staining, and Nissl staining ...
Shuo Yang, Xin‐qi Gao, Ai‐hua Tan, Pan Ge   +3 more
wiley   +1 more source

Atg5 in microglia regulates sex-specific effects on postnatal neurogenesis in Alzheimer's disease. [PDF]

NPJ Aging
Walter E, Angst G, Bollinger J, Truong L, Ware E, Wohleb ES, Fan Y, Wang C.   +7 more
europepmc   +1 more source

S100b expression in and effects on microglia [PDF]

, 2001
Cecilia Adami, Guglielmo Sorci, Elisabetta Blasi, Anna Lisa Agneletti, Francesco Bistoni, Rosario Donato   +5 more
openalex   +1 more source

Serotonergic modulators in Alzheimer's disease: a hope in the hopeless condition

Chemistry &Biodiversity, Accepted Article.
Alzheimer disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Ali I. Al-Gareeb, Morkoss Fakhry, Ali K. Albuhadily, Athanasios Alexiou, Marios Papadakis, Gaber El-Saber Batiha   +5 more
wiley   +1 more source

Parthenolide regulates microglial and astrocyte function in primary cultures from ALS mice and has neuroprotective effects on primary motor neurons. [PDF]

PLoS One
Thau-Habermann N, Gschwendtberger T, Bodemer C, Petri S.   +3 more
europepmc   +1 more source

Translational Medicine in Alzheimer's Disease: The Journey of Donanemab From Discovery to Clinical Application

Chronic Diseases and Translational Medicine, EarlyView.
Donanemab, approved by the U.S. FDA in July 2024, targets amyloid plaques in the brain to treat Alzheimer's disease in patients with mild cognitive impairment or mild dementia. ABSTRACT Substantial research has been conducted to identify an efficient treatment for Alzheimer's disease (AD).
Nandhini Jayaprakash, Karthikeyan Elumalai   +1 more
wiley   +1 more source

Microglia determine an immune-challenged environment and facilitate ibuprofen action in human retinal organoids. [PDF]

J Neuroinflammation
Schmied V, Korkut-Demirbaş M, Venturino A, Maya-Arteaga JP, Siegert S.   +4 more
europepmc   +1 more source

Enhancing TREM2 expression activates microglia and modestly mitigates tau pathology and neurodegeneration. [PDF]

J Neuroinflammation
Chen K, Li F, Zhang S, Chen Y, Ikezu TC, Li Z, Martens YA, Qiao W, Meneses A, Zhu Y, Xhafkollari G, Bu G, Zhao N.   +12 more
europepmc   +1 more source

Increased Serum Neurofilament Light Chain Concentration Associated With Microglial Morphology Changes in Chronically‐Starved Mice

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is associated with hyperactivity, amenorrhea, and brain atrophy. Weight rehabilitation reversed these symptoms, although the underlying pathophysiological mechanisms are mostly unknown. Serum neurofilament light chain (NfL) levels are widely used as a biomarker of neurodegeneration. Based on neuroimaging studies
Annelie Zimmermann, Hanna Rupprecht, Stephan Lang, Rickmer Wienecke, Hanna‐Sophia Henschke, Kaja Dickert, Katharina Schuster, Anna Staffeld, Christoph Berger, Alexander Dück, Michael Kölch, Antje Vogelgesang, Matthias Grothe, Leo Heinig, Lukas Wenzel, Markus Kipp, Linda Frintrop   +16 more
wiley   +1 more source

ATP11B Modulates Microglial Lipid Metabolism and Alleviates Alzheimer's Disease Pathology. [PDF]

MedComm (2020)
Zhang Y, Zhang S, Zhao X, Wu P, Ying Y, Wu L, Zhuang J, Chen Z, Chao Y, Dong X, Zhao RC, Wang J.   +11 more
europepmc   +1 more source