Results 251 to 260 of about 388,044 (340)

ApoE4 Homozygosity Is Associated With Increased Microglia Activation in Fatal COVID-19. [PDF]

Neuropathology
Hamdan A, El-Amri Y, Heinrich F, Mohamed OAA, Sepulveda-Falla D, Glatzel M, Matschke J, Krasemann S.   +7 more
europepmc   +1 more source

Assessing the Nature of Human Brain‐Derived Extracellular Vesicles on Synaptic Activity Via the Development of an Air‐liquid Microfluidic Platform

Advanced Science, EarlyView.
This seminal study highlights the interwoven and tightly regulated functions of brain‐derived extracellular vesicles. Using microfluidics, proteomics, and AI‐based electric signal analyses of cortical brain explants, this work provides a useful resource dataset revealing the composition of human brain‐derived extracellular vesicles obtained from ...
Corentin Bernou, Yukiko Iwasaki, Willy Lutz, Glaucia Almeida, Emilie Béchard, François Delalande, Magali Rompais, Jules Bouget, Barbara Gorda, Chantal Cazevieille, Yonis Bare, Christine Carapito, Sophie Colomb, Gowrishankar Ganesh, Raphael Gaudin   +14 more
wiley   +1 more source

Microglial Prrc2a regulates microglia-neuron interaction in cerebellum and motor functions in mice. [PDF]

iScience
Li X, Yang P, Dong B, Jiang L, Xiu R, Guo J, Li S, Zhang P, Gu R, Li A, Zhang J, Wu R, Wang F, Shen Y, Shao N, Cheng J, Yuan Z.   +16 more
europepmc   +1 more source

Nasal Mucosa‐Derived Extracellular Vesicles as a Systemic Antiaging Intervention

Advanced Science, EarlyView.
This study shows that nasal mucosa‐derived extracellular vesicles (nmEVs) exert systemic anti‐ageing effects in mice by restoring circadian rhythm, suppressing cellular senescence, and improving cognitive function. In aged human bone marrow mesenchymal stem cells, nmEVs reverse senescence‐associated phenotypes and reactivate core clock gene expression.
Wentao Shi, Lu Bian, Mengyuan Yu, Jun Wang, Mingzhu Gao, Liping Shen, Xiao Zhang, Zhiliang Huang, Hong Tang, Long Lv, Yunduan Que, Zengli Miao, Xuechao Wu, Qing Wang, Xiaojie Lu   +14 more
wiley   +1 more source

Metabolic Flexibility of Microglia: Energy Substrate Utilization and Impact on Neuronal Metabolism. [PDF]

J Neurochem
Westi EW, Carlsen RB, Andersen JV, Kilic Z, Alnajar D, Holmgaard NK, Sintes BG, Cota-Coronado A, Muñoz SS, Galvagnion C, Aldana BI.   +10 more
europepmc   +1 more source

New tools for studying microglia in the mouse and human CNS

Proceedings of the National Academy of Sciences of the United States of America, 2016
Mariko L. Bennett, F. C. Bennett, S. A. Liddelow, S. A. Liddelow, Bahareh Ajami, Jennifer L Zamanian, Nathaniel B. Fernhoff, Sara B. Mulinyawe, Christopher J. Bohlen, Aykezar Adil, Andrew Tucker, I. Weissman, E. Chang, Gordon Li, G. Grant, M. Gephart, B. Barres   +16 more
semanticscholar   +1 more source

Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse Model

Advanced Science, EarlyView.
Transplantation of medial ganglionic eminence (MGE) interneuron progenitors into APP/PS1 cortices restored the slow oscillation characteristic of Alzheimer's disease. Donor cells survived, migrated, and matured into functional GABAergic interneurons, forming synaptic connections.
Shinya Yokomizo, Megi Maci, April M. Stafford, Morgan R. Miller, Stephen J. Perle, Shuzo Inagaki, Shusaku Takahashi, Heather Brown‐Harding, Linda Liang, Alex Lovely, Moustafa Algamal, Rebecca L. Gillani, Theodore J. Zwang, Douglas Richardson, Janice R. Naegele, Daniel Vogt, Ksenia V. Kastanenka   +16 more
wiley   +1 more source

TNFAIP3 alleviates cerebral ischemia-reperfusion injury by inhibiting M1 microglia polarization via deubiquitination of RACK1. [PDF]

PLoS One
Bai W, Liu S, Zhou G, Li X, Jiang H, Shao J, Zhu J.   +6 more
europepmc   +1 more source

Curcumin Suppresses Janus Kinase-STAT Inflammatory Signaling through Activation of Src Homology 2 Domain-Containing Tyrosine Phosphatase 2 in Brain Microglia [PDF]

, 2003
Hak Yong Kim, Eun Jung Park, Eun-hye Joe, Ilo Jou   +3 more
openalex   +1 more source

Mapping Satellite Glial Cell Heterogeneity Reveals Distinct Spatial Organization and Implies Functional Diversity in the Dorsal Root Ganglion

Advanced Science, EarlyView.
Four distinct satellite glial cell subtypes are identified in mouse dorsal root ganglia using single‐cell RNA sequencing and spatial validation. These subtypes show unique marker profiles and anatomical distributions. Human dorsal root ganglia display layered perisomatic organization with differential marker expression.
Ole Andreas Ahlgreen, Mads Würgler Hansen, Jonas Baake, Thomas Engelbrecht Hybel, Rachele Rossi, Xin Lai, Ishwarya Sankaranarayanan, Johanne Amalie Pold, Lin Lin, Line Reinert, Søren Riis Paludan, Theodore John Price, Lone Tjener Pallesen, Christian Bjerggaard Vægter   +13 more
wiley   +1 more source