Results 261 to 270 of about 358,908 (302)
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2019
Microglial cells derive from fetal macrophages which immigrate into and disseminate throughout the central nervous system (CNS) in early embryogenesis. After settling in the nerve tissue, microglial progenitors acquire an idiosyncratic morphological phenotype with small cell body and moving thin and highly ramified processes currently defined as ...
Olga Garaschuk +3 more
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Microglial cells derive from fetal macrophages which immigrate into and disseminate throughout the central nervous system (CNS) in early embryogenesis. After settling in the nerve tissue, microglial progenitors acquire an idiosyncratic morphological phenotype with small cell body and moving thin and highly ramified processes currently defined as ...
Olga Garaschuk +3 more
openaire +8 more sources
Interaction of Microglia and Astrocytes in the Neurovascular Unit
Frontiers in Immunology, 2020 The interaction between microglia and astrocytes significantly influences neuroinflammation. Microglia/astrocytes, part of the neurovascular unit (NVU), are activated by various brain insults.
Lirong Liu +4 more
exaly +2 more sources
Microscopy Research and Technique, 2001
AbstractThis paper reviews the various proposed hypotheses on the origin of microglia. The seminal study of del Rio‐Hortega first stated that the cells were derived from the mesodermal pial cells that invaded the brain during embryonic development. Along with this was the description of precursor cells in the yolk sac in early development.
Kaur, C. +3 more
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AbstractThis paper reviews the various proposed hypotheses on the origin of microglia. The seminal study of del Rio‐Hortega first stated that the cells were derived from the mesodermal pial cells that invaded the brain during embryonic development. Along with this was the description of precursor cells in the yolk sac in early development.
Kaur, C. +3 more
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Glia, 1993
AbstractThe most characteristic property of microglia is their swift activation in response to neuronal stress and their capacity for site‐directed phagocytosis. The transformation of microglia into intrinsic brain macrophages appears to be under strict control and takes place if neuronal and/or terminal degeneration occurs in response to nerve lesion.
Jochen Gehrmann +3 more
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AbstractThe most characteristic property of microglia is their swift activation in response to neuronal stress and their capacity for site‐directed phagocytosis. The transformation of microglia into intrinsic brain macrophages appears to be under strict control and takes place if neuronal and/or terminal degeneration occurs in response to nerve lesion.
Jochen Gehrmann +3 more
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Neuropharmacology
TREM2 is a membrane receptor solely expressed on microglia in normal brain. In this review we outline recent advances in TREM2 biology and its implications for microglial function, with particular emphasis on findings from iPSC-derived microglia (iMG) expressing TREM2 loss-of-function mutations.
Jennifer Pocock +3 more
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TREM2 is a membrane receptor solely expressed on microglia in normal brain. In this review we outline recent advances in TREM2 biology and its implications for microglial function, with particular emphasis on findings from iPSC-derived microglia (iMG) expressing TREM2 loss-of-function mutations.
Jennifer Pocock +3 more
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2022
Microglia, a category of glial cells in the central nervous system (CNS), have attracted much attention because of their important role in neuroinflammation. Many translational studies are currently ongoing to discover novel drugs targeting microglia for the treatment of various CNS disorders, such as Alzheimer's disease, Parkinson's disease (PD), and ...
Tomomitsu, Iida +2 more
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Microglia, a category of glial cells in the central nervous system (CNS), have attracted much attention because of their important role in neuroinflammation. Many translational studies are currently ongoing to discover novel drugs targeting microglia for the treatment of various CNS disorders, such as Alzheimer's disease, Parkinson's disease (PD), and ...
Tomomitsu, Iida +2 more
openaire +2 more sources
Microglia mediate forgetting via complement-dependent synaptic elimination
Science, 2020Microglia modulate memories Synaptic reorganization and circuit rewiring leads to loss or weakening of connections between neurons and may result in the erasure of previously formed memories. Microglia eliminate excessive synapses in the developing brain
Chao Wang +11 more
semanticscholar +1 more source
Microglia in neuroregeneration
Microscopy Research and Technique, 2001AbstractMicroglia has the potential to produce and release a range of factors that directly and/or indirectly promote regeneration in the injured nervous system. The overwhelming evidence indicates, however, that this potential is generally not expressed in vivo.
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Genetic targeting of microglia
Glia, 2014Genetic targeting of microglia and other myeloid cells in the central nervous system (CNS) is highly desirable as they are critical effectors and regulators of changes in CNS homeostasis during development as well as in health and disease. Therefore, genetic reprogramming of microglia could constitute a central approach for potentially reducing disease
Wieghofer, Peter +2 more
openaire +4 more sources
2002
Microglia, the principal immune effector cells of the central nervous system (CNS), were originally described by del Rio-Horgeta (1). Microglia constitute 5–15% of the total glial cell population present in the adult CNS, and it is estimated (2) that there are as many microglia cells as neurons, which emphasizes their importance in the CNS.
V. Wee Yong, Sophie Chabot
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Microglia, the principal immune effector cells of the central nervous system (CNS), were originally described by del Rio-Horgeta (1). Microglia constitute 5–15% of the total glial cell population present in the adult CNS, and it is estimated (2) that there are as many microglia cells as neurons, which emphasizes their importance in the CNS.
V. Wee Yong, Sophie Chabot
openaire +2 more sources