Results 151 to 160 of about 12,345 (165)

Efficient ligase 3-dependent microhomology-mediated end joining repair of DNA double-strand breaks in zebrafish embryos

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2015
DNA double-strand break (DSB) repair is of considerable importance for genomic integrity. Homologous recombination (HR) and non-homologous end joining (NHEJ) are considered as two major mechanistically distinct pathways involved in repairing DSBs.
Hua-Lin Wang, Zuo-Yan Zhu, Yonghua Sun   +2 more
exaly   +2 more sources

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Insertion sequence excision is enhanced by a protein that catalyzes branch migration and promotes microhomology‐mediated end joining

Genes to Cells, 2023
Insertion sequence (IS)‐excision enhancer (IEE) promotes the excision of ISs in the genome of enterohemorrhagic Escherichia coli O157. Because IEE‐dependent IS excision occurs in the presence of transposase, the process of IS transposition may be ...
Ren Kishino, Takashi Saito, Shuntaro Muto, Yuzuka Tomita, Yasuhiko Sekine   +4 more
semanticscholar   +1 more source

A Simple Knock-In System for Xenopus via Microhomology Mediated End Joining Repair

2018
Following completion of the genome sequences of Xenopus tropicalis and X. laevis, gene targeting techniques have become increasingly important for the further development of Xenopus research in the life sciences. Gene knockout using programmable nucleases, such as TALEN and CRISPR/Cas9, has reached a level whereby we can readily and routinely perform ...
Ken-Ich T, Suzuki, Yuto, Sakane, Miyuki, Suzuki, Takashi, Yamamoto   +3 more
openaire   +2 more sources

CRISPR-Cas9 and Microhomology-Mediated End-Joining for Biosynthetic Pathway Reconstruction in Aspergillus fumigatus.

Methods in molecular biology
Yaojie Guo, Daniel H Scharf
semanticscholar   +2 more sources

Cyclin D1 Overexpression in Mantle Cell Lymphoma Causes Cellular Dependence on Microhomology-Mediated End-Joining

Blood
Oncoprotein-driven human cancers exhibit replication stress (RS), leading to an increase in DNA double-strand breaks (DSB). These DSBs are repaired by one of the three main pathways - homologous recombination repair (HR), non-homologous end-joining ...
J. Abeykoon, S. Asada, G. Zu, Y. Hirohashi, Divya R Iyer, K. Parmar, Lige Jiang, S. Mukkavalli, Dongni Yi, M. Manske, Xiaosheng Wu, Kimberly A. Gwin, T. Witzig, G. Shapiro, Alan D. D’Andrea   +14 more
semanticscholar   +1 more source

Real-Time Visualization of G2L4 Reverse Transcriptase in DNA Repair via Microhomology-Mediated End Joining

bioRxiv
Double-strand break repair (DSBR) is essential for genome integrity, yet mechanistic details of error-prone microhomology-mediated end joining (MMEJ) remain unclear.
Pangmiaomiao Zhang, Mo Guo, Y. J. Zhang, Alan M. Lambowitz, Yi-Chih Lin   +4 more
semanticscholar   +1 more source

Abstract A029: c-MYC/BCL2 induced replication stress drives dependence on POLQ-mediated microhomology-mediated end joining in aggressive large B-cell lymphoma

Blood Cancer Discovery
Large B-cell lymphoma (LBCL) harboring chromosomal rearrangements (double-hit, DH) or coexpression of MYC and BCL2 (double-expressor, DE) represents biologically aggressive subgroups with inferior clinical outcomes.
Cecilia Ayala-Zambrano, D. Yi, M. Manske, K. Gwin, Richard K. Kandasamy, S. Dasari, Anne J Novak, S. Asada, Xiaosheng Wu, Zhenkun Lou, T. Witzig, J. Abeykoon   +11 more
semanticscholar   +1 more source

Author Correction: Polλ promotes microhomology-mediated end-joining

Nature Structural & Molecular Biology, 2023
Gurushankar Chandramouly, Joonas Jamsen, Nikita Borisonnik, Mrityunjay Tyagi, Marissa L. Calbert, Taylor Tredinnick, Ahmet Y. Ozdemir, Tatiana Kent, Elena V. Demidova, Sanjeevani Arora, Samuel H. Wilson, Richard T. Pomerantz   +11 more
openaire   +1 more source

Context-Dependent Regulation of Microhomology-Mediated End Joining in Normal Tissues: Insights into Tissue-Specific Activation of DNA Repair Pathways

bioRxiv
Diksha Rathore
semanticscholar   +1 more source

Tissue-Specific Activation of Microhomology-Mediated End Joining with Age Reflects Dynamic Rewiring of DNA Repair in Rats

bioRxiv
Diksha Rathore
semanticscholar   +1 more source