Results 141 to 150 of about 12,345 (165)
Some of the next articles are maybe not open access.
Biochemistry (Moscow)
Double-strand DNA break (DSB) repair mechanisms vary in their ability to prevent errors during end joining. The joining of DSBs on different chromosomes can result in translocations, potentially leading to tumorigenesis. This review examines the main mechanisms of DSB repair and factors influencing their selection, as well as contribution of these ...
N. Lomov +3 more
semanticscholar +3 more sources
Double-strand DNA break (DSB) repair mechanisms vary in their ability to prevent errors during end joining. The joining of DSBs on different chromosomes can result in translocations, potentially leading to tumorigenesis. This review examines the main mechanisms of DSB repair and factors influencing their selection, as well as contribution of these ...
N. Lomov +3 more
semanticscholar +3 more sources
Homology and enzymatic requirements of microhomology-dependent alternative end joining
Cell Death and Disease, 2015 Nonhomologous DNA end joining (NHEJ) is one of the major double-strand break (DSB) repair pathways in higher eukaryotes. Recently, it has been shown that alternative NHEJ (A-NHEJ) occurs in the absence of classical NHEJ and is implicated in chromosomal ...
Sathees C Raghavan
exaly +2 more sources
Structure, 2015 DNA polymerase theta (Polθ) has been identified as a crucial alternative non-homologous end-joining factor in mammalian cells. Polθ is upregulated in a range of cancer cell types defective in homologous recombination, and knockdown has been shown to ...
Joseph A Newman +2 more
exaly +3 more sources
A human cell-based reporter detects microhomology-mediated end joining [PDF]
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2012 DNA double-strand breaks (DSBs) are most often repaired by two pathways in mammalian cells, homologous recombination or non-homologous end joining. Biochemical and genetic studies showed that DSBs can also be joined via microhomology-mediated end joining (MHEJ), which is always mutagenic and may result in diseases, such as cancer.
Yanguo Liu +2 more
exaly +3 more sources
Microhomology-Mediated End Joining as a Novel Mechanism Underlying Androgen Insensitivity Syndrome
medRxivAbstract Significance Statement This study identifies microhomology-mediated end joining (MMEJ) as a novel mutational mechanism underlying a pathogenic deletion in the androgen receptor gene in a patient with complete androgen insensitivity syndrome.
J. Marques +12 more
semanticscholar +2 more sources
bioRxivG-quadruplexes are four-stranded nucleic acid structures that are formed by guanine rich sequences. They have been implicated to interfere with telomere maintenance, but their effects are not well understood at a molecular level.
Samah Matmati +2 more
semanticscholar +2 more sources
Highly efficient CRISPR mutagenesis by microhomology-mediated end joining in Aspergillus fumigatus
Fungal Genetics and Biology, 2016Filamentous fungi have a dominant nonhomologous-end joining (NHEJ) DNA repair pathway, which results in the majority of transformed progenies having random heterologous insertion mutagenesis. Thus, lack of a versatile genome-editing tool prevents us from carrying out precise genome editing to explore the mechanism of pathogenesis.
Chi Zhang, Ling Lu
exaly +3 more sources
Involvement of Ku80 in microhomology-mediated end joining for DNA double-strand breaks in vivo
DNA Repair, 2007Mammalian cells have an activity of mutagenic repair for DNA double-strand breaks (DSBs), microhomology-mediated end joining (MMEJ), in which DNA ends are joined via microhomologous sequences flanking the breakpoint. MMEJ has been indicated to be undertaken without Ku proteins, which are essential factors for non-homologous end joining (NHEJ).
Masanori Sato +2 more
exaly +3 more sources
Cell Death & Differentiation
Repair of DNA double-strand breaks (DSBs) is essential for cells to maintain genome stability and cell survival. While cyclic GMP-AMP synthase (cGAS) is best known for its role in innate immunity, emerging evidence reveals that it plays regulatory roles in DNA damage response.
Haibo Yang +10 more
semanticscholar +3 more sources
Repair of DNA double-strand breaks (DSBs) is essential for cells to maintain genome stability and cell survival. While cyclic GMP-AMP synthase (cGAS) is best known for its role in innate immunity, emerging evidence reveals that it plays regulatory roles in DNA damage response.
Haibo Yang +10 more
semanticscholar +3 more sources
Methods in molecular biology
DNA replication mediated by DNA polymerases is important not only for replicating genomic DNA but also for repairing damaged DNA. Elucidating the function of each DNA polymerase is essential for understanding how genomic integrity is maintained. Here, we present two types of DNA polymerase assays: one is the conventional method using sequence gel and ...
Yubin Sung +3 more
semanticscholar +3 more sources
DNA replication mediated by DNA polymerases is important not only for replicating genomic DNA but also for repairing damaged DNA. Elucidating the function of each DNA polymerase is essential for understanding how genomic integrity is maintained. Here, we present two types of DNA polymerase assays: one is the conventional method using sequence gel and ...
Yubin Sung +3 more
semanticscholar +3 more sources