Results 121 to 130 of about 12,345 (165)

DNA end configurations dictate synaptic complex formation during NHEJ-mediated end bridging

Nature Communications
Synapsis, the physical bridging of two broken DNA ends, is a critical step in non-homologous DNA end joining (NHEJ), the primary pathway for repairing DNA double-strand breaks (DSBs) in vertebrates.
Chenyang Zhang, Weiwei Jin, Yuhao Jiang, Weilin Li, Rongguo Fu, Keyin Qi, Wantao Li, Chao Zhao, Di Liu, Bailin Zhao   +9 more
doaj   +1 more source

Toward Precision Molecular Surgery: Robust, Selective Induction of Microhomology-mediated End Joining in vivo

, 2018
One key problem in precision genome editing is the resultant unpredictable plurality of sequence outcomes at the site of targeted DNA double-strand breaks (DSBs).
Karl J. Clark, Kyle J. Schaefbauer, Alexey V. Dvornikov, Alvin C. Ma, Hirotaka Ata, Carla M. Mann, Stephen C. Ekker, Drena Dobbs, Thomas L. Ekstrom, Gabriel Martínez-Gálvez   +9 more
core   +1 more source

The enterohemorrhagic Escherichia coli insertion sequence-excision enhancer protein is a DNA polymerase with microhomology-mediated end-joining activity. [PDF]

Nucleic Acids Res, 2023
Calvo PA, Mateo-Cáceres V, Díaz-Arco S, Redrejo-Rodríguez M, de Vega M.   +4 more
europepmc   +1 more source

The E3 ubiquitin ligase DTX3L and the deubiquitinase USP28 fine-tune DNA repair through mutual regulation of their protein levels

iScience
Summary: The DNA damage response (DDR) relies on a complex protein network to maintain genomic integrity, yet the interplay between post-translational modifiers remains poorly understood.
Daniela Mennerich, Yashwanth Ashok, Carlos Vela-Rodríguez, Heli I. Hentilä, Melanie Rall-Scharpf, Lisa Wiesmüller, Renata Prunskaite-Hyyryläinen, Lari Lehtiö, Thomas Kietzmann   +8 more
doaj   +1 more source

Recent advances in CRISPR-Cas9-based genome insertion technologies

Molecular Therapy: Nucleic Acids
Programmable genome insertion (or knock-in) is vital for both fundamental and translational research. The continuously expanding number of CRISPR-based genome insertion strategies demonstrates the ongoing development in this field.
Xinwen Chen, Jingjing Du, Shaowei Yun, Chaoyou Xue, Yao Yao, Shuquan Rao   +5 more
doaj   +1 more source

Impaired induction of DNA lesions during immunoglobulin class-switch recombination in humans influences end-joining repair

, 2010
Ig class-switch recombination (CSR) is a region-specific process that exchanges the constant Ig heavy-chain region and thus modifies an antibody's effector function.
Sven Kracker, Kohsuke Imai, Alain Fischer, Pauline Gardès, Hans D. Ochs, Anne H. Durandy   +5 more
core   +1 more source

Dynamic interplay of cNHEJ and MMEJ pathways of DNA double-strand break repair during embryonic development in zebrafish

Scientific Reports
Double strand breaks (DSBs) are the most deleterious DNA lesions as they frequently result in mutations when repaired by canonical non homologous end-joining (cNHEJ) and microhomology-mediated end-joining (MMEJ).
Mathieu Carrara, Anne-Laure Gaillard, Alice Brion, Evelyne Duvernois-Berthet, Carine Giovannangeli, Jean-Paul Concordet, Guillaume Pézeron   +6 more
doaj   +1 more source

Involvement of Illegitimate V(D)J Recombination or Microhomology-Mediated Nonhomologous End-Joining in the Formation of Intragenic Deletions of the Notch1 Gene in Mouse Thymic Lymphomas

, 2004
Deregulated V(D)J recombination-mediated chromosomal rearrangements are implicated in the etiology of B- and T-cell lymphomagenesis. We describe here three pathways for the formation of the 5' deletions of Notch1 gene in thymic lymphomas of wild-type or ...
勝部 孝則, 相澤 志郎, Aizawa, Shirou, 土居 雅広, Katsube, Takanori, 石井 洋子, 442410, 442411, 442412, Ukai, Hideki, 442413, 442414, 442415, 442416, 442417, Tsuji, Hideo, Doi, Masahiro, 442418, 442419, Ishii-Ohba, Hiroko, Ogiu, Toshiaki, 荻生 俊昭, 辻 秀雄, 442420, 442421, 442422, 442423, 442424, Hioki, Kyoji, 鵜飼 英樹   +29 more
core  

Microhomology-mediated end joining in fission yeast is repressed by pku70 and relies on genes involved in homologous recombination.

, 2007
Two DNA repair pathways are known to mediate DNA double-strand-break (DSB) repair: homologous recombination (HR) and nonhomologous end joining (NHEJ).
Decottignies, Anabelle
core   +1 more source

A role for ATM kinase activity and Mre11 in microhomology-mediated end-joining [PDF]

Cell Cycle, 2010
Anthony J. Davis, David J. Chen
openaire   +1 more source