Results 111 to 120 of about 12,345 (165)

Distinct functions of PAXX and MRI during chromosomal end joining

iScience
Summary: A key step of canonical-nonhomologous end joining is synapsis of DNA double-strand break (DSB) ends, which appears to be mediated by both the DNA-PKcs dimer and XLF homodimer. We have examined this process by monitoring end joining (EJ) of blunt
Metztli Cisneros-Aguirre, Felicia Wednesday Lopezcolorado, Xiaoli Ping, Ruby Chen, Jeremy M. Stark   +4 more
doaj   +1 more source

Investigations of telomere maintenance in DNA damage response defective cells and telomerase in brain tumours

, 2005
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University, 17/03/2005.Telomeres are nucleoprotein complexes located at the end of chromosomes. They have an essential role in protecting chromosome ends.
Cabuy, Erik
core  

Comparative analysis of multiple DNA double-strand break repair pathways in CRISPR-mediated endogenous tagging

Communications Biology
CRISPR-mediated endogenous tagging is a powerful tool in biological research. Inhibiting the non-homologous end joining (NHEJ) pathway has been shown to improve the low efficiency of accurate knock-in via homology-directed repair (HDR).
Chiharu Tei, Shoji Hata, Akira Mabuchi, Shotaro Okuda, Kei K. Ito, Mariya Genova, Masamitsu Fukuyama, Shohei Yamamoto, Takumi Chinen, Atsushi Toyoda, Daiju Kitagawa   +10 more
doaj   +1 more source

Contribution of Microhomology to Genome Instability: Connection between DNA Repair and Replication Stress

, 2022
Microhomology-mediated end joining (MMEJ) is a highly mutagenic pathway to repair double-strand breaks (DSBs). MMEJ was thought to be a backup pathway of homologous recombination (HR) and canonical nonhomologous end joining (C-NHEJ). However, it attracts
Yuning Jiang, Jiang, Yuning
core   +1 more source

Polymerase theta repairs persistent G1-induced DNA breaks in S-phase during class switch recombination

Nature Communications
Non-homologous end joining (NHEJ) is the primary pathway for repairing G1 phase-induced DNA double-strand breaks (DSBs) during immunoglobulin heavy chain (Igh) class switch recombination (CSR) in B lymphocytes.
Timea Marton, Jinglong Wang, Amaury Vaysse, Wei Yu, Pierre-Henri Commere, Quentin Holleville, Tristan Espie-Caullet, Richard Frock, Ludovic Deriano   +8 more
doaj   +1 more source

ATM Kinase and BLM Helicase: A Regulator and Key Player in Microhomology-Mediated End Joining

, 2010
Microhomology-mediated end joining (MMEJ) is a class of DNA repair used to join DNA ends following a double-strand break (DSB). It represents an unfavorable and error-prone pathway because it results in deletion of nucleotides between microhomologies, as
Treister, Daniel
core  

Essential Roles for Polymerase θ-Mediated End Joining in the Repair of Chromosome Breaks

, 2016
DNA polymerase theta (Pol θ)-mediated end joining (TMEJ) has been implicated in the repair of chromosome breaks, but its cellular mechanism and role relative to canonical repair pathways are poorly understood.
Ramsden, Dale A., Wyatt, David W., Feng, Wanjuan, Conlin, Michael P., Yousefzadeh, Matthew J., Mieczkowski, Piotr, Roberts, Steven A., Gupta, Gaorav P., Wood, Richard D.   +8 more
core   +1 more source

Pol θ-Mediated End-Joining Uses Microhomologies Containing Mismatches

DNA polymerase theta (Pol θ) initiates repair of DNA double-strand breaks by pairing single strands at short microhomologies . It is important to understand microhomology selection, as some cancer cells rely on Pol θ for survival.
Dang, Ngoc K, Liu, Bin, Xu, Han, Carvajal-Maldonado, Denisse, Li, Yuzhen, Returan, Mark, Wood, Richard D, He, Wei, Guerin, Adele T   +8 more
core   +1 more source

Application of an F0-based genetic assay in adult zebrafish to identify modifier genes of an inherited cardiomyopathy

Disease Models & Mechanisms, 2023
Yonghe Ding, Mingmin Wang, Haisong Bu, Jiarong Li, Xueying Lin, Xiaolei Xu   +5 more
doaj   +1 more source

RNA-mediated double-strand break repair by end-joining mechanisms

Nature Communications
Double-strand breaks (DSBs) in DNA are challenging to repair. Cells employ at least three DSB-repair mechanisms, with a preference for non-homologous end joining (NHEJ) over homologous recombination (HR) and microhomology-mediated end joining (MMEJ ...
Youngkyu Jeon, Yilin Lu, Margherita Maria Ferrari, Tejasvi Channagiri, Penghao Xu, Chance Meers, Yiqi Zhang, Sathya Balachander, Vivian S. Park, Stefania Marsili, Zachary F. Pursell, Nataša Jonoska, Francesca Storici   +12 more
doaj   +1 more source