Results 131 to 140 of about 12,345 (165)

The Role of BLM Helicase in Mammalian Microhomology-Mediated End Joining

, 2010
DNA repair pathways are important for the maintenance of genomic integrity and critical to the survival and health of an organism. In order to effectively eliminate damaged segments of DNA, DNA repair mechanisms require the separation of the two ...
Hossain, Aneesha
core  

CRISPR-Cas12a enables precise microhomology-mediated DNA replacement

The development of more efficient and precise methods to engineer the cellular genome is an essential aim in synthetic biology, life sciences and medicine.
GRAZIOLI, SIMONA
core  

Mitochondrial genome microhomology-mediated editing by donor DNA delivery into mitochondria in human cells. [PDF]

Mol Ther Nucleic Acids
Maximov VV, Shebanov N, Nikitchina N, Rapoport R, Maor Y, Tarassov I, Pines O, Entelis N.   +7 more
europepmc   +1 more source

Non-canonical double-stranded DNA break repair in Pseudomonas aeruginosa includes LigD-independent non-homologous end joining. [PDF]

Nucleic Acids Res
Hare PJ, González JR, Truong A, Mok WWK.   +3 more
europepmc   +1 more source

In vivo gene correction with targeted sequence substitution through microhomology-mediated end joining

Biochemical and Biophysical Research Communications, 2018
Genome editing technology using programmable nucleases has rapidly evolved in recent years. The primary mechanism to achieve precise integration of a transgene is mainly based on homology-directed repair (HDR).
Suresh Ramakrishna, Sunghoon Kim, Junwon Lee   +2 more
exaly   +6 more sources

Defective Microhomology-Mediated End-joining in SMARCB1-Deficient Tumors

bioRxiv
Rhabdoid tumors (RTs) are highly aggressive cancers driven by biallelic mutation of SMARCB1, a core subunit of the BAF (SWI/SNF) complex. We found that SMARCB1-deficient tumors have a defect in the microhomology-mediated end-joining (MMEJ) pathway, and ...
G. Zhu, S. Asada, Huy Nguyen, Y. Hirohashi, Lifang Sun, Avneesh Saravanapavan, Sirisha Mukkavalli, G. I. Shapiro, Alan D. D’Andrea   +8 more
semanticscholar   +4 more sources

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CRISPR-mediated host genomic DNA damage is efficiently repaired through microhomology-mediated end joining in Zymomonas mobilis

Journal of Genetics and Genomics, 2021
CRISPR-Cas systems provide bacteria and archaea with adaptive immunity against mobile genetic elements (MGEs) through uptake of invader-derived spacers.
Bo Wu, Zhufeng Zhang, Jing Liu
exaly   +2 more sources

The Role of Microhomology-Mediated End Joining (MMEJ) at Dysfunctional Telomeres.

Cold Spring Harbor Perspectives in Biology
DNA double-strand break (DSB) repair pathways are crucial for maintaining genome stability and cell viability. However, these pathways can mistakenly recognize chromosome ends as DNA breaks, leading to adverse outcomes such as telomere fusions and ...
D. Billing, Agnel Sfeir
semanticscholar   +3 more sources

PARP1 and PARP2 are dispensable for DNA repair by microhomology-mediated end-joining during mitosis

bioRxiv
Poly ADP-ribose polymerase (PARP) inhibitors are standard of care treatment for cancers with homologous-recombination deficiencies. Yet, as tumors develop resistance, complementary strategies are emerging, including targeting microhomology-mediated end ...
Raquel Ortega, Erin R Taylor, Sophie M. Whitehead, T. Danhorn, B. Bitler, Nausica Arnoult   +5 more
semanticscholar   +3 more sources

Microhomology-mediated end joining acts directly on replication forks to repair single-ended double-strand breaks.

Molecular Cell
Replication stress, intrinsic to oncogenesis, often leads to fork breakage and double-strand break (DSB) formation. Conventionally, break-induced replication (BIR) is considered the primary mechanism for repairing replication-associated single-ended DSBs
Shibo Li, Yuqin Zhao, Youhang Li, S. Shah, Yanmeng Shi, Tran Nguyen, Zi Wang, Chia-Yu Chang, Anagh Ray, Te Bu, Salvatore Loguercio, Takayo Sasaki, Jonathan H. Sussman, Hailong Wang, David M. Gilbert, M. Aladjem, Xiaohua Wu   +16 more
semanticscholar   +4 more sources