Results 101 to 110 of about 12,345 (165)

Generation of a recipient line for Rubisco engineering by multiplex genome editing in tobacco

The Plant Journal, Volume 126, Issue 4, May 2026.
SUMMARY Rubisco (ribulose 1,5‐bisphosphate carboxylase/oxygenase) is the primary CO2‐fixing enzyme on our planet. Its slow kinetics and poor discrimination between carbon dioxide and oxygen as substrates severely limit the efficiency of photosynthetic carbon fixation by plants.
Gonçalo E. da Silva, Stephan Obst, Pedro Carvalho, Joachim Forner, Stephanie Ruf, Nelson J. M. Saibo, Ralph Bock   +6 more
wiley   +1 more source

Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells [PDF]

, 2013
Microhomology-mediated end joining (MMEJ) is a major pathway for Ku-independent alternative nonhomologous end joining, which contributes to chromosomal translocations and telomere fusions, but the underlying mechanism of MMEJ in mammalian cells is not ...
Truong, Lan N, Razavian, Niema, Wang, Hailong, Hwang, Patty Yi-Hwa, Berns, Michael W, Shi, Linda Z, He, Jing, Wu, Xiaohua, Li, Yongjiang   +8 more
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, Volume 20, Issue 4, Page 1061-1073, April 2026.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Pan‐3D Genome Analysis Reveals the Roles of Structural Variation in Chicken Chromatin Architectures, Domestication and Production Traits

Advanced Science, Volume 13, Issue 24, 27 April 2026.
This study firstly presents a comprehensive and high‐resolution pan‐3D genome resource in chicken. Our findings reveal the role of structural variations in 3D genome architectures, and how they influence the domestication process and production traits at the 3D genome level.
Zhen Zhou, Danfeng Cai, Changbin Zhao, Siyu Zhang, Jiahao Li, Zhaofeng Zhang, Shaofen Kong, Xin Yang, Xiaoli Zhou, Farhad Bordbar, Fayi Chen, Yaohuan Xu, Zhe Zhang, Lihong Gu, Zhenhui Li, Xiquan Zhang, Wen Luo, Jingting Shu, Bolin Cai, Qinghua Nie   +19 more
wiley   +1 more source

Causative Role for a BRCA2 Germline Pathogenic Variant in External Auditory Canal Squamous Cell Carcinoma

Genes, Chromosomes and Cancer, Volume 65, Issue 4, April 2026.
ABSTRACT External auditory canal squamous cell carcinoma (EACSCC) is rare, affecting 1.6 in a million individuals. We report a case of EACSCC in a 66‐year‐old woman carrying a heterozygous BRCA2 germline pathogenic variant (GPV) (c.8537_8538del), with prior history of breast cancer.
José Camacho‐Valenzuela, Dylan Pelletier, Paz Polak, Lili Fu, Nancy Hamel, Carla Daniela Robles‐Espinoza, William D. Foulkes   +6 more
wiley   +1 more source

Non-homologous end joining often uses microhomology: implications for alternative end joining. [PDF]

, 2014
Artemis and PALF (also called APLF) appear to be among the primary nucleases involved in non-homologous end joining (NHEJ) and responsible for most nucleolytic end processing in NHEJ.
Watanabe, Go, Pannunzio, Nicholas, Lieber, Michael, Li, Sicong   +3 more
core   +1 more source

Stabilisation of Tomato Yellow Leaf Curl China Virus Infectious Clones Through Micro‐Homology Mediated End Joining

Plant Biotechnology Journal, Volume 24, Issue 4, Page 2187-2200, April 2026.
ABSTRACT Tomato yellow leaf curl China virus (TYLCCNV) is a major agricultural pathogen and primary model for circular single‐stranded DNA (cssDNA) virus studies. The infectious clones of TYLCCNV and other cssDNA viruses are usually constructed as two tandem copies of the small viral genomes in Agrobacterium‐mediated T‐DNA vectors.
Anxiang Wang, Tian Meng, Ju Wang, Xiaomei Xu, Dan Li, Zhanqing Lv, Aiqi Yan, Mian Zhou, Bo Ding, Qiuying Yang   +9 more
wiley   +1 more source

Microhomology-mediated deletion and gene conversion in African trypanosomes. [PDF]

, 2010
Antigenic variation in African trypanosomes is induced by DNA double-strand breaks (DSBs). In these protozoan parasites, DSB repair (DSBR) is dominated by homologous recombination (HR) and microhomology-mediated end joining (MMEJ), while non-homologous ...
Glover, Lucy, Horn, David, Horn, David; id_orcid, Jun, Junho, Lucy Glover, David Horn, Junho Jun   +6 more
core   +1 more source

Microhomology-mediated end joining drives complex rearrangements and overexpression of MYC and PVT1 in multiple myeloma

, 2020
\ua92020 Ferrata Storti FoundationMYC is a widely acting transcription factor and its deregulation is a crucial event in many human cancers. MYC is important biologically and clinically in multiple myeloma, but the mechanisms underlying its dysregulation
Mikulasova A, Mavrommatis K, Bauer MA, Walker BA, Ashby C, Keats J, Rosenthal A, Tian E, Jackson GH, Yaccoby S, Davies FE, Ryan KR, Wardell CP, Qu P, Dent JA, Hoering A, Deshpande S, Morgan GJ, Tytarenko RG, Auclair D, Trotter M, Thakurta A   +21 more
core  

DNA double strand break repair in human bladder cancer is error prone and involves microhomology-associated end-joining.

, 2004
In human cells DNA double strand breaks (DSBs) can be repaired by the non-homologous end-joining (NHEJ) pathway. In a background of NHEJ deficiency, DSBs with mismatched ends can be joined by an error-prone mechanism involving joining between regions of ...
Diggle, CP, Kiltie, AE, Kiltie, Anne, Bentley, J, Harnden, P, Knowles, MA   +5 more
core   +1 more source