Results 241 to 250 of about 28,349 (334)

Partial Deletion of the Carboxyl‐Terminal Signal Sequence of the Cellular Prion Protein Alters Protein Expression via Endoplasmic Reticulum–Associated Degradation

The FASEB Journal, Volume 39, Issue 17, 15 September 2025.
Knock‐in mice expressing PrP with a partial deletion of the C‐terminal signal sequence (KIBVPrP248) showed reduced PrPC expression and resistance to prion infection. The underlying mechanism is that the mutant PrP is aberrantly retained in the endoplasmic reticulum and eventually undergoes proteasomal degradation.
Miryeong Yoo, Sungeun Lee, Jieun Kim, Sunyeong Cha, Min Young Lee, Yeon Jeong Hwang, Woo‐Ri Ko, Taeeun Kim, A‐ran Kim, Trang H. T. Trinh, Young‐Mi Kim, Yong‐Pil Cheon, Chongsuk Ryou   +12 more
wiley   +1 more source

Microfluidic Mechanoporation: Current Progress and Applications in Stem Cells. [PDF]

Biosensors (Basel)
Wang R, Wang Z, Tong L, Wang R, Yao S, Chen D, Hu H.   +6 more
europepmc   +1 more source

Experimental intra-ovum infection of coho salmon (Oncorhynchus kisutch) eggs with Renibacterium salmoninarum using a microinjection technique

, 1990
LL Brown, R Ricks, TPT Evelyn, L. J. Albright   +3 more
openalex   +1 more source

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

Advanced Science, Volume 12, Issue 33, September 4, 2025.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu, Wuhui He, Yun Xiao, Qiong Wu, Qing Zhang, Tiesong Zhang, Lei Xu, Xinyi Pang   +7 more
wiley   +1 more source

Neurokinin1 - cholinergic receptor mechanisms in the medial Septum-Dorsal hippocampus axis mediates experimental neuropathic pain. [PDF]

Neurobiol Pain
Zacky Ariffin M, Yun Ng S, Nadia H, Koh D, Loh N, Michiko N, Khanna S.   +6 more
europepmc   +1 more source

Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis

Advanced Science, Volume 12, Issue 34, September 11, 2025.
Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu, Shengyu Jin, Xin Fu, Chong Xie, Yi Chen, Liangtang Chang, Yongheng Fan, Donghua He, Xiaoqi Hong, Xi Shen, Xiaoli Zheng, Qiyue Wang, Dao Shi, Fangyuan Li, Daishun Ling, Yangtai Guan, Neng Gong, Xiaoping Tong   +17 more
wiley   +1 more source

Methotrexate carried in lipid core nanoparticles reduces microglial activation and induces neuroprotection after cortical stroke induced in rats. [PDF]

Clinics (Sao Paulo)
Pereira ELR, Maranhão RC, Dias MNC, Dos Santos IR, Dos Santos CR, Hamoy M, Feio DCA, Carvalho PO, Bazioli JM, Morikawa AT, Gomes-Leal W.   +10 more
europepmc   +1 more source

Foreign Gene Expression in Barley Coleoptile Epidermis: An Improved System for Gene Transfer and in situ Detection of Gene Expression by Dual Microinjection.

, 1992
Yoshinori Matsuda, Hideyoshi Toyoda, Yasushi NOGI, Takayuki TAMAI, Seiji OUCHI   +4 more
openalex   +2 more sources

Microinjection patent granted [PDF]

Nature, 1989
openaire   +2 more sources

CRISPR Screening Reveals a Novel Role for FOXH1 in Regulating Pluripotency of Porcine Embryonic Stem Cells

Advanced Science, Volume 12, Issue 34, September 11, 2025.
This study performs dual CRISPR screens in pEPSCs. Fitness screening identifies essential genes for viability, while FACS‐based screening uncovers core pluripotency factors. It highlights FOXH1 as a key regulator that maintains the stem cell state through a dual‐action mechanism: preserving pluripotency by enhancing chromatin accessibility and ...
Peng Su, Linhui Wu, Delong Li, Wenting Song, Dagang Tao, Liang Liu, Qi Wang, Manxin Gao, Tian Xu, Xin Liu, Shengsong Xie, Xia Zhang, Jilong Zhou, Yi‐Liang Miao   +13 more
wiley   +1 more source