Results 41 to 50 of about 28,349 (334)

Serotonin-3 Receptors in the Posterior Ventral Tegmental Area Regulate Ethanol Self-Administration of Alcohol-Preferring (P) Rats [PDF]

, 2010
Several studies indicated the involvement of serotonin-3 (5-HT 3 ) receptors in regulating alcohol- drinking behavior. The objective of this study was to determine the involvement of 5-HT 3 receptors within the ventral tegmental area (VTA) in ...
Beardsley, Campbell, Carboni, Ding, Ding, Fadda, Ford, Gatto, Herve, Hodge, Hodge, Hodge, Ikemoto, Ikemoto, Ikemoto, Ikemoto, James M. Murphy, Jamie E. Toalston, Katner, Klein, Knapp, Koob, Liu, Liu, Lovinger, McKinzie, McKinzie, Minabe, Nowak, Nowak, Paxinos, Prisco, Rasmussen, Richard L. Bell, Rodd, Rodd, Rodd, Rodd, Rodd, Rodd, Rodd-Henricks, Rodd-Henricks, Rodd-Henricks, Scott M. Oster, Sung, Svensson, Toalston, Tomkins, Tylene J. Pommer, Van Bockstaele, William J. McBride, Wozniak, Zachary A. Rodd   +52 more
core   +1 more source

Nucleus accumbens corticotropin-releasing factor increases cue-triggered motivation for sucrose reward: paradoxical positive incentive effects in stress?

BMC Biology, 2006
Background Corticotropin-releasing factor (CRF) is typically considered to mediate aversive aspects of stress, fear and anxiety. However, CRF release in the brain is also elicited by natural rewards and incentive cues, raising the possibility that some ...
Schulkin Jay, Peciña Susana, Berridge Kent C   +2 more
doaj   +1 more source

Birth prevalence of genital anomalies among males conceived by intracytoplasmic sperm injection cycles: A cross-sectional study

International Journal of Reproductive BioMedicine, 2023
Background: Several studies have been conducted worldwide to evaluate the prevalence and relative risks of congenital anomalies associated with assisted reproductive technology cycles; however, there is limited data in Iran.
Fatemeh Aliani, Zahra Haghshenas, Ahmad Vosough Dizaj, Arezoo Arabipoor, Samira Vesali, Mahnaz Ashrafi   +5 more
doaj   +1 more source

Melanin-Concentrating Hormone (MCH): Role in REM Sleep and Depression. [PDF]

, 2015
The melanin-concentrating hormone (MCH) is a peptidergic neuromodulator synthesized by neurons of the lateral sector of the posterior hypothalamus and zona incerta.
Benedetto, Luciana, Chase, Michael H, Lagos, Patricia, López-Hill, Ximena, Monti, Jaime M, Pascovich, Claudia, Scorza, Cecilia, Torterolo, Pablo, Urbanavicius, Jessika   +8 more
core   +3 more sources

Microinjection of mRNAs and Oligonucleotides [PDF]

Cold Spring Harbor Protocols, 2018
Microinjecting lineage tracers into a single blastomere in the normal, intact embryo identifies the repertoire of cell types derived from it. In order to reveal the full developmental potential of that blastomere or identify the mechanisms by which its fate is determined, one needs to modify its gene expression under controlled experimental conditions.
openaire   +3 more sources

Modulation of Neurally Mediated Vasodepression and Bradycardia by Electroacupuncture through Opioids in Nucleus Tractus Solitarius. [PDF]

, 2018
Stimulation of vagal afferent endings with intravenous phenylbiguanide (PBG) causes both bradycardia and vasodepression, simulating neurally mediated syncope.
Fu, Liang-Wu, Guo, Zhi-Ling, Longhurst, John C, Tjen-A-Looi, Stephanie C   +3 more
core   +3 more sources

Versatile Cell Penetrating Peptide for Multimodal CRISPR Gene Editing in Primary Stem Cells

Advanced Functional Materials, EarlyView.
CRISPR machinery in diverse molecular formats (DNA, RNA, and ribonucleic protein) is complexed into nanoparticles with the cell‐friendly arginine‐alanine‐leucine‐alanine (RALA) cell‐penetrating peptide. Nanoparticles are delivered to primary mesenchymal stem cells ex vivo or locally in vivo to facilitate multimodal CRISPR gene editing. This RALA‐CRISPR
Joshua P. Graham, Jose Gabriel Castro, Lisette C. Werba, Joseph Amitrano, Luke Fardone, Kevin P. Francis, Anand Ramamurthi, Michael J. Layden, Helen O. McCarthy, Tomas Gonzalez‐Fernandez   +9 more
wiley   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Microinjection of dsRNA in Tardigrades [PDF]

Cold Spring Harbor Protocols, 2018
Classical genetic analysis in the tardigrade Hypsibius exemplaris is a challenge because these animals are parthenogens. The publication of the H. exemplaris genome has facilitated the study of targeted genes by RNA interference (RNAi), a robust mechanism to disrupt gene function. This protocol describes microinjection of double-stranded RNA (dsRNA) in
openaire   +3 more sources

Angiotensin type 1A receptors in C1 neurons of the rostral ventrolateral medulla modulate the pressor response to aversive stress [PDF]

, 2012
The rise in blood pressure during an acute aversive stress has been suggested to involve activation of angiotensin type 1A receptors (AT(1A)Rs) at various sites within the brain, including the rostral ventrolateral medulla.
Allen, Andrew M., Bassi, Jaspreet K., Chen, Daian, Choong, Yan-Ting, Davern, Pamela J., Gurley, Susan B., Head, Geoffrey A., Jancovski, Nikola, Nguyen-Huu, Thu-Phuc, Palma-Rigo, Kesia, Thomas, Walter G.   +10 more
core   +1 more source