Results 51 to 60 of about 28,349 (334)

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

\u3cem\u3eN\u3c/em\u3e-acetylcysteine Decreases Binge Eating in a Rodent Model [PDF]

, 2016
Binge-eating behavior involves rapid consumption of highly palatable foods leading to increased weight gain. Feeding in binge disorders resembles other compulsive behaviors, many of which are responsive to N-acetylcysteine (NAC), which is a cysteine ...
Baker, David A., Choi, Sujean, Frenkel, M. M., Hurley, M. M., Maunze, Brian, Resch, Jon M.   +5 more
core   +1 more source

Reconfigurable Microenvironments Uncover Mechano‐Sensing Timescales and Direct Cell Polarity

Advanced Functional Materials, EarlyView.
A synthetic DNA‐crosslinked cell culture matrix enables control over the mechanical microenvironment surrounding cells. Independent tuning of stiffness and stress relaxation uncovers distinct timescales of mechano‐sensing that regulate cell behavior.
Syuan‐Ku Hsiao, Markus Mukenhirn, Carsten Werner, Alf Honigmann, Elisha Krieg   +4 more
wiley   +1 more source

Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

Advanced Healthcare Materials, EarlyView.
This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla, Vincenzo Verdi, Willemijn de Voogt, Mariona Estapé Sentí, Arnold C. Koekman, Julian Rietveld, Sven van Kempen, Qiangbing Yang, Juliette van Merris, Guido Jenster, Martin E. van Royen, Marcel H. Fens, Sander A. A. Kooijmans, Wytske M. van Weerden, Guillaume van Niel, Pieter Vader, Raymond M. Schiffelers   +16 more
wiley   +1 more source

Respiratory effects of kynurenic acid microinjected into the ventromedullary surface of the rat

Brazilian Journal of Medical and Biological Research, 1998
Several studies demonstrate that, within the ventral medullary surface (VMS), excitatory amino acids are necessary components of the neural circuits involved in the tonic and reflex control of respiration and circulation.
F.P. Tolentino-Silva, A.K. Russo, S.L. Cravo, O.U. Lopes   +3 more
doaj   +1 more source

Role of raphe magnus 5-HT1A receptor in increased ventilatory responses induced by intermittent hypoxia in rats

Respiratory Research, 2022
Background Intermittent hypoxia induces increased ventilatory responses in a 5-HT-dependent manner. This study aimed to explore that effect of raphe magnus serotonin 1A receptor (5-HT1A) receptor on the increased ventilatory responses induced by ...
Jiao Su, Yang Meng, Yifei Fang, Linge Sun, Mengge Wang, Yanjun Liu, Chunling Zhao, Liping Dai, Songyun Ouyang   +8 more
doaj   +1 more source

Multifunctional Neural Probes Enable Bidirectional Electrical, Optical, and Chemical Recording and Stimulation In Vivo

Advanced Materials, EarlyView.
Convergence drawing is used to create flexible, microscale, multifunctional fiber‐based neural probes. Optimized materials selection enables individual devices to perform neural recording, electrical stimulation, optogenetics, fiber photometry, fluid delivery, and voltammetric neurotransmitter detection in rodents.
Nicolette Driscoll, Marc‐Joseph Antonini, Taylor M. Cannon, Pema Maretich, Greatness Olaitan, Valerie Doan Phi Van, Keisuke Nagao, Atharva Sahasrabudhe, Emmanuel Vargas Paniagua, Ethan J. Frey, Ye Ji Kim, Sydney Hunt, Melissa Hummel, Sanju Mupparaju, Alan Jasanoff, B. Jill Venton, Polina Anikeeva   +16 more
wiley   +1 more source

Distinct sites of opiate reward and aversion within the midbrain identified using a herpes simplex virus vector expressing GluR1 [PDF]

, 2000
Repeated administration of morphine increases expression of GluR1 (an AMPA glutamate receptor subunit) in the ventral tegmental area (VTA) of the midbrain, an important neural substrate for the rewarding actions of morphine.
Carlezon, W. A., Coopersmith, R., Haile, C. N., Hayashi, Y., Malinow, R., Nestler, E. J., Neve, R. L.   +6 more
core   +1 more source

Droplet‐Based Synthesis of Nanogels for Controlled Drug Delivery via Two Photon Polymerization‐3D Printed Microfluidic Device

Advanced Materials Technologies, EarlyView.
A miniaturized microfluidic device is 3D printed via two‐photon polymerization and used for the droplet‐based microfluidic synthesis of nanogels for controlled drug delivery purposes. Tuning the fluid flow parameters, the microfluidic system enables the modulation of nanogel size and properties, preserving an extremely low polydispersity, beyond the ...
Vladimir Matining, Camillo Colli, Emanuela Jacchetti, Giulia Nicoletti, Laura Rosanò, Manuela Teresa Raimondi, Bianca Maria Colosimo, Emanuele Mauri, Davide Moscatelli   +8 more
wiley   +1 more source

Thioperamide-induced Antinociception is Mediated through Endogenous Opioid System in the Dentate Gyrus of Adult Rats [PDF]

Veterinary Research Forum, 2010
The present study investigated the effects of intra-dentate gyrus microinjection of naloxone (an opioid antagonist) and thioperamide (an antagonist of histamine H3 receptors) in the formalin test in rats. Subcutaneous injection of formalin (50 µl, 2.5 %)
Emad Khalilzadeh, Esmaeal Tamaddonfard, Amir-Abbas Farshid, Amir Erfanparast   +3 more
doaj