Results 81 to 90 of about 28,349 (334)
Drug Delivery Technologies for the Treatment of Age‐Related Macular Degeneration
Advanced Science, EarlyView.There are multiple therapeutic agents available for the treatment of both dry age‐related macular degeneration (AMD) and wet AMD. It is essential to continue innovation by introducing new drug delivery technologies that can incorporate those along with patient compliance and the accessibility of the technology into the early stages of research and ...
J Jesus Rodriguez‐Cruz +4 more
wiley +1 more source
Microinjections observed by MMS FEEPS in the dusk to midnight region
Geophysical Research Letters, 2016 Energetic electron injections are commonly observed in the premidnight to dawn regions in association with substorms. However, successive electron injections are generally separated in time by hours and are rarer in the dusk region of the inner ...
J. F. Fennell +17 more
doaj +1 more source
Evidence for energetic electron and iondispersive microinjections in theEarth's magnetotail as far as 27 RE [PDF]
Annales Geophysicae, 2004 High energy and time resolution measurements of energetic electron and ion fluxes obtained by the DOK-2 experiment on board the Interball-tail satellite provide us the opportunity to study the short-lived (1–3min), localized, and often periodic and ...
D. V. Sarafopoulos +2 more
doaj +1 more source
Temporal properties of cerebellar-dependent memory consolidation [PDF]
, 2004 Classical conditioning of the nictitating membrane response in rabbits is a well defined model of cerebellar-dependent motor memory. This memory undergoes a period of consolidation after the training session, when it is sensitive to reversible ...
Attwell, PJE, Cooke, SF, Yeo, CH
core +1 more source
Advanced Science, EarlyView.Context associated with morphine withdrawal elicits an increase in serum corticosterone levels. Corticosterone participates in CTR‐MWM by acting on MR, but not GR, in the BLA. MR in BLA→NAcC neurons mediates CTR‐MWM. MR increases presynaptic glutamate release and meanwhile participates in D1 receptor‐induced increases in presynaptic glutamate release ...
Zixuan Cao +15 more
wiley +1 more source
Advanced Science, EarlyView.Sleep deprivation triggers systemic immune activation characterized by neutrophil accumulation and cytokine release. This study reveals a conserved metabolic‒epigenetic mechanism whereby lactate‐induced H3K18 lactylation upregulates RORα expression, promoting neutrophilic inflammation.
Ren Zhou +15 more
wiley +1 more source
Mapping a Novel Hedonic Hotspot in the Orbitofrontal Cortex [PDF]
, 2014 Honors (Bachelor's)PsychologyUniversity of Michiganhttp://deepblue.lib.umich.edu/bitstream/2027.42/107703/1/mikewkh ...
Wu, Kuan Hua
core
Advanced Science, EarlyView.PCSK9 acts as a molecular chaperone promoting LIN28A lysosomal degradation. LIN28A elevates transcription factor HES5, increasing JMY expression. PCSK9 loss causes neural tube defects (NTDs) by disrupting the LIN28A/HES5/JMY axis, and high JMY disorganizes the neural progenitor cell microfilament network, leading to incomplete neural tube structure in ...
Xiaoshuai Li +6 more
wiley +1 more source
Heliyon, 2019 Background: Microinjections, lesions, viral-mediated gene transfer, or designer receptors exclusively activated by designer drugs (DREADDs) can identify brain signaling pathways and their pharmacology in research animals. Genetically modified animals are
Shirisha Meda +5 more
doaj +1 more source
Role of the thalamic parafascicular nucleus cholinergic system in the modulation of acute corneal nociception in rats [PDF]
, 2011 The present study investigated the effects of microinjections of acetylcholine (a cholinergic agonist), physostigmine (a cholinesterase inhibitor), atropine (an antagonist of muscarinic cholinergic receptors) and hexamethonium (an antagonist of nicotinic
Amir-Abbas Farshid +3 more
core