Results 141 to 150 of about 36,831 (386)

Implantable Silk Composite Microneedles for Programmable Vaccine Release Kinetics and Enhanced Immunogenicity in Transcutaneous Immunization [PDF]

, 2013
Microneedle vaccines mimic several aspects of cutaneous pathogen invasion by targeting antigen to skin-resident dendritic cells and triggering local inflammatory responses in the skin, which are correlated with enhanced immune responses.
Bachmann, Chen, Chen, del Pilar Martin, DeMuth, DeMuth, DeMuth, DeMuth, Gray, Gross, Jewell, Johansen, Kim, Kim, Koutsonanos, Lanford, Levine, Lin, Mueller, Nestle, Numata, Pritchard, Reetoo, Rockwood, Sallusto, Shaulov, Stahl-Hennig, Tseng, Tsioris, Turner, Wenk, Woodland, You, Yue, Zammit, Zhang   +35 more
core   +1 more source

Bioinspired Smart Nanogels for Rapid Blue Laser‐Activated Hemostasis in Gastrointestinal Bleeding

Advanced Materials, EarlyView.
Waxberry‐inspired branched‐silica nanogel can swiftly stop bleeding upon blue laser endoscopy for gastrointestinal hemostasis in the esophagus, stomach, and duodenum of mini‐pigs. Abstract Gastrointestinal bleeding (GIB) is a critical condition that requires rapid and effective intervention.
Ruijue Dan, Yu Huang, Shali Tan, Kaige Xu, Yuchen Zhang, Zhaohui Luan, Paipai Qi, Xingyue Zhang, Donghui Zhu, Wen Zhong, Chaoqiang Fan, Malcolm Xing, Shiming Yang   +12 more
wiley   +1 more source

A microneedle vaccine printer for thermostable COVID-19 mRNA vaccines

Nature Biotechnology, 2023
A. vander Straeten, M. Sarmadi, John L. Daristotle, Maria Kanelli, Lisa H. Tostanoski, Joe Collins, A. Pardeshi, Jooli Han, Dhruv Varshney, Behnaz Eshaghi, Johnny Garcia, Timothy A Forster, Gary Li, N. Menon, Sydney L Pyon, Linzixuan Zhang, C. Jacob-Dolan, O. Powers, Kevin Hall, Shahad K. Alsaiari, Morris Wolf, M. Tibbitt, R. Farra, D. Barouch, R. Langer, A. Jaklenec   +25 more
semanticscholar   +1 more source

Carbon Quantum Dots Assisted Virus Tracking: From Skin to Brain

Advanced Materials, EarlyView.
A novel carbon quantum dots‐dissolvable microneedle, CQDs‐dMN system, enables painless delivery and real‐time tracking of HSV‐1. The HSV‐1 is labeled with fluorescent CQDs and delivered to the skin dermis, minimizing damage compared to traditional methods.
Yaxiu Feng, Xiong Wang, Cien Chen, Di Wang, Changshun Hou, Yiran Wang, Huan Hu, Peiran Chen, LeiYing Qin, Qianya Wan, Xi Yao, Ming‐Liang He   +11 more
wiley   +1 more source

Versatile Platforms of Microneedle Patches Loaded with Responsive Nanoparticles: Synthesis and Promising Biomedical Applications

Advanced NanoBiomed Research
Microneedle array systems loaded with responsive nanoparticles have received increasing attention due to the advantages of good drug stability, targeting ability, controlled release of drugs, high bioavailability, painlessness, and good patient ...
Rixin Xie, Wenjing Li, Kexin Shi, Li Yang, Hongzhong Chen, Shaoyun Jiang, Xiaowei Zeng   +6 more
doaj   +1 more source

A Bio-Inspired Swellable Microneedle Adhesive for Mechanical Interlocking with Tissue [PDF]

, 2014
Achieving significant adhesion to soft tissues while minimizing tissue damage poses a considerable clinical challenge. Chemical-based adhesives require tissue-specific reactive chemistry, typically inducing a significant inflammatory response.
Bouma, Brett E., Cho, Woo Kyung, Karp, Jeffrey M., O'Cearbhaill, Eoin D., Park, Kyeng Min, Pomahac, Bohdan, Sisk, Geoffroy C., Villiger, Martin, Yang, Seung Yun   +8 more
core   +1 more source

Zinc‐Coordinated Trienzyme Nanogel Cascade Therapy for Accelerated Post‐Pancreatectomy Cutaneous Wound Healing

Advanced Materials, EarlyView.
A zinc‐coordinated nanogel assembly is reported that co‐delivers three enzymes to regulate glucose, oxidative stress, and oxygen levels. This system mimics natural enzyme cascades to reprogram the wound environment after pancreatectomy. In a post‐pancreatectomy mouse model, it accelerates healing by reducing infection, promoting blood vessel growth ...
Yedong Ma, Chengke Xie, Chengyu Liao, Binting Huang, Siqi Liu, Junhua Kong, Xiaotong Fan, Zibiao Li, Shi Chen, Chaobin He   +9 more
wiley   +1 more source

Computational and Experimental Analysis of Drug‐Coated Microneedle Skin Insertion: The Mode of Administration Matters

Advanced Materials Interfaces, EarlyView.
This study investigates how the mode of application affects drug delivery from coated microneedles. Combining finite element modeling with custom 3D‐printed Franz Diffusion Cells, the researchers found that prolonged application pressure from microneedles in situ reduces drug permeation.
Wenting Shu, Thomas Lijnse, Fiona McCartney, David J. Brayden, Aisling Ní Annaidh, Eoin D. O'Cearbhaill   +5 more
wiley   +1 more source

Silicon micromachined hollow microneedles for transdermal liquid transport [PDF]

, 2003
Han Gardeniers, Regina Lüttge, Erwin Berenschot, Meint J. de Boer, S.Y. Yeshurun, M. Hefetz, Ronny van't Oever, Albert van den Berg   +7 more
openalex   +1 more source

Implantable Microarray Patch: Engineering at the Nano and Macro Scale for Sustained Therapeutic Release via Synthetic Biodegradable Polymers

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
This review focuses on the application of synthetic biodegradable microarray patches (MAPs) in sustained drug delivery. Compared to conventional MAPs which release drugs into the skin in an immediate manner, these implantable MAPs release drugs into skin microcirculation gradually as the biodegradable polymers degrade, thus offering sustained release ...
Li Zhao, Akmal Hidayat Bin Sabri, Mary B. McGuckin, Linlin Li, Zihao Wang, Eneko Larrañeta, Ryan F. Donnelly   +6 more
wiley   +1 more source