Results 151 to 160 of about 18,959 (275)

Kirigami‐Inspired Deployable Microneedle Robot With Enhanced Conformability for Targeted Oral Drug Delivery

Small, EarlyView.
We have engineered a kirigami‐inspired deployable microneedle robot (KiriBot) capable of remotely controlled attachment to target tissues for sustained drug release. KiriBot incorporates a flexible structure that enhances conformability, improves adherence to irregular tissues, and facilitates microneedle insertion.
Kun Zhou, Rujie Sun, Yuyang Zuo, David J. Peeler, Jonathan Yeow, Ruoxiao Xie, Junliang Lin, Yiming Ma, Yue Shao, Yuanxiong Cao, Zhengkun Chen, Molly M. Stevens   +11 more
wiley   +1 more source

Low-Shrinkage 3D-Printed Polymeric Microneedle Arrays with Electroless Silver Coating for Enhanced Thermal and Mechanical Performance in Dermatological Applications. [PDF]

Materials (Basel)
Xu Y, Li S, Liu J, Li Z, Pan X, Li D, Mao S, Liu W, Li Y, Guo X, Tong Y, Liu G, Wang J.   +12 more
europepmc   +1 more source

Multi‐Scale 3D Printing of Magnetic Polymer Nanocomposites with Controlled Particle Dispersion and Hyperthermic Response

Small, EarlyView.
Dispersion of magnetic nanoflowers in trimethylolpropane ethoxylate triacrylate to generate photocurable nanocomposites is described. Particle dispersion provides processability and target AC‐field stimulated temperature increases. Complex (DLP) printed structures with submicron features are demonstrated, and the potential for stimulated release of ...
Eoin P. McKiernan, Jacek K. Wychowaniec, Danielle Winning, Shane Clerkin, Ines Martinez‐‐Chauvin, John Crean, Alexa Ennis, Colm Delaney, Larisa Florea, Dermot F. Brougham   +9 more
wiley   +1 more source

Next-generation microneedle patches for transdermal therapeutics and diagnostics. [PDF]

Discov Nano
Chen TH, Hsu MT, Lee KH, Karmakar R, Mukundan A, Kuzhali SS, Chou CK, Lin WS, Wang HC.   +8 more
europepmc   +1 more source

Fenestrated Microneedle Biosensor for Continuous In Vivo Lactate Monitoring in Interstitial Fluid

Small, EarlyView.
A fenestrated microneedle biosensor enables continuous transdermal monitoring of lactate in interstitial fluid while protecting the functional sensing interface during insertion into the skin. The platform delivers sensitive electrochemical lactate detection and distinguishes metabolic profiles in healthy and type 2 diabetic‐obese mice, and captures ...
Masoud Khazaei, Ali‐Reza Shokouhi, Parham Sahandi Zangabad, Victor J. Cadarso, Muamer Dervisevic, Nicolas H. Voelcker   +5 more
wiley   +1 more source

Real-time, cross-modal genotype mapping of free-moving <i>Drosophila</i> larvae via simultaneous mechano-electrophysiological recording. [PDF]

Sci Adv
Dong K, Song H, Zhao Q, Song Z, Lv F, Wan S, Zheng T, Fan Y, Liu WC, Zhang S, Wu Y, Huang Y, Song J, Gong Z, Zheng N, Nan K.   +15 more
europepmc   +1 more source

One‐Pot Fabrication of Pentapeptide Bio‐Aerogel via Direct Alcogelation

Small, EarlyView.
A minimal tachykinin‐inspired pentapeptide (TC‐1) self‐assembles in water and ethanol to form robust gels that can be dried in one pot to ultra‐porous aerogels using supercritical carbon dioxide. Solvent choice programs nanoscale packing and bulk mechanics producing lightweight monoliths with high porosity for biomaterials applications, verified by ...
Brody McDonald, Durga Dharmadana, Nevena Todorova, Boyin Liu, Shuaiyu Jiang, Ewan W. Blanch, Céline Valéry   +6 more
wiley   +1 more source

Mechanical Properties and Fabrication of Bioinspired Cactus Spine Microneedles. [PDF]

Biosensors (Basel)
Liu H, Long X, Sun Q, Wu S, Yuan Z.
europepmc   +1 more source

Highly Efficient and Cytocompatible Panchromatic Photoinitiators for Photopolymerization and High‐Resolution 3D Printing beyond 450 nm

Small, EarlyView.
Phenothiazine photoinitiators P1 and P2 exhibit panchromatic photoinitiation through efficient SET with iodonium salts. P2 enables rapid red‐light polymerization, while both systems perform under sunlight and smartphone light. P1 supports 460 nm DLP 3D printing and shows lower cytotoxicity than TPO, offering safer photoinitiators for high‐precision ...
Tong Gao, Jing Zhang, Xiaotong Peng, Michael Schmitt, Fabrice Morlet‐Savary, Céline Dietlin, Li Wang, Jacques Lalevée, Pu Xiao   +8 more
wiley   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source