Results 181 to 190 of about 11,396 (262)

Deep Learning Prediction of Surface Roughness in Multi‐Stage Microneedle Fabrication: A Long Short‐Term Memory‐Recurrent Neural Network Approach

Advanced Intelligent Discovery, Volume 2, Issue 4, August 2026.
A sequential deep learning framework is developed to model surface roughness progression in multi‐stage microneedle fabrication. Using real‐world experimental data from 3D printing, molding, and casting stages, an long short‐term memory‐based recurrent neural network captures the cumulative influence of geometric parameters and intermediate outputs ...
Abdollah Ahmadpour, Sara Soltanabadi Farshi, Tuanna Ozcan, Amir Mohammad Ketabchi, Alper Kiraz, Savas Tasoglu   +5 more
wiley   +1 more source

A spatiotemporally coordinated curcumin-based microneedle patch for SDF-1α delivery and synergistic myocardial infarction therapy. [PDF]

J Nanobiotechnology
Jiang XY, Luo Y, Yang Y, Tang DW, Wang Z, Huang P, Wang FZ, Zhang SM, Zhang HM, Ma YY, Liu XC, Li YR, Zheng W, Zhang L, Yu XY, He G.   +15 more
europepmc   +1 more source

Mesenchymal stem cell‐derived exosomes for cardiac repair: Challenges, standardization gaps and a realistic path to clinical translation

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Mesenchymal stem cell‐derived exosomes (MSC‐sEVs) show preclinical promise for cardiac repair via anti‐inflammatory, anti‐apoptotic, pro‐angiogenic and anti‐fibrotic effects. However, translational hurdles remain, including non‐standardized isolation, unvalidated potency assays, incomplete GMP manufacturing, and lack of completed Phase II/III trials ...
Sakhavat Abolhasani, Yasin Ahmadi, Amin Jalizih   +2 more
wiley   +1 more source

FEA-guided co-design of bubble microneedles: controlled tip separation for rapid transdermal and sublingual delivery. [PDF]

Drug Deliv
Jiang C, Yang J, Gao M, He Y, Liao W, Chen H, Wang Z, Ying S, Tao X, Jiang X, Ye J.   +10 more
europepmc   +1 more source

Applications of Bioinorganic Nano‐Based Delivery Systems—Diagnostics and Therapeutics

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Nanotechnology has emerged as a promising avenue for producing nanomedicines as alternatives to conventional drugs. Many organic nanoparticles, such as liposomes used in formulations like Doxil, Onivyde, and Marqibo, are approved by the Food and Drug Administration (FDA) and instrumental in treating various types of cancers.
Frank Ssengooba, Jubilee Andrew, Donald Fernandes   +2 more
wiley   +1 more source

Working towards a single-dose vaccine for rabies post-exposure prophylaxis. [PDF]

Future Virol
Graf TP, McHugh KJ.
europepmc   +1 more source

Comparison of Dried Blood Spot Sampling Methods for RNA‐Based Biomarker Measurement in Anti‐Doping

Drug Testing and Analysis, Volume 18, Issue 8, Page 959-966, August 2026.
This study demonstrates that RNA‐based biomarkers of erythropoiesis, ALAS2 and CA1, can be reliably quantified across commonly used DBS sampling matrices, including venous and capillary blood spotted on cellulose cards and the Tasso‐M20 device. ABSTRACT Dried blood spot (DBS) sampling offers logistical advantages, but it remains unexplored whether ...
Jacob Bejder, Corentin Schlechten, Claudia Mumenthaler, Olivier Salamin, Tiia Kuuranne, Thomas Christian Bonne, Jonathan Graae, Henrik Sørensen, Nikolai B. Nordsborg, Nicolas Leuenberger   +9 more
wiley   +1 more source

Fast-Dissolving Sodium Alginate-Based Microneedle Patch Integrating Tranilast and Glabridin-Loaded Nanoparticles for Dual-Action Hypertrophic Scar Therapy. [PDF]

Biomater Res
Younas A, Sohail M, Li Y, Zhou Q, Shen Y, Wang S, Shi Y, Shang Z, Shao C, Xiao J.   +9 more
europepmc   +1 more source

Bone Marrow Stem Cell Exosomes Protect Lung Cells from Oxygen Damage by Regulating miR‐23a‐3p/Slc7a2 Pathway

The Journal of Gene Medicine, Volume 28, Issue 8, August 2026.
Exosomal miR‐23a‐3p from BMSCs directly targets Slc7a2 mRNA. By repressing Slc7a2, miR‐23a‐3p suppresses hyperoxia‐triggered apoptosis, facilitates proliferation and reduces ROS production in AECIIs in vitro. The miR‐23a‐3p/Slc7a2 axis modulates numerous biochemical markers in AECII supernatant and neonatal rat serum under hyperoxia (P 〈 0.05 ...
Qifei He, Huaiwu Zheng, Junhao Xiong, Wei Yang   +3 more
wiley   +1 more source

A ROS-responsive core-shell microneedle platform integrating sonodynamic gas antibacterial therapy and modulating immunity for diabetic wound healing. [PDF]

J Nanobiotechnology
Wang P, Ai F, Huang G, Shen Y, Cui F, Deng H, Liang C, Xie J, Kang J, Zhu Y, Xiong W, Tao J.   +11 more
europepmc   +1 more source