Results 91 to 100 of about 33,747 (400)

Bioengineering a Patient‐Derived Vascularized Lung Tumor‐on‐Chip Model to Decipher Immunomodulation by the Endothelium

Advanced Healthcare Materials, EarlyView.
Most in vitro cancer models lack cellular diversity, functional complexity, and clinical relevance. This work highlights the generation of an innovative dynamic tetraculture with autologous patient‐derived cells within a vascularized tumor‐on‐chip, as well as the recapitulation of endothelial anergy features induced by the tumor microenvironment ...
Christine Lansche, Ségolène Ladaigue, Giacomo Gropplero, Nicolas Zimmermann, Martin Nurmik, Irina Veith, Manh‐Louis Nguyen, Solenn Brosseau, Nicolas Poté, Pierre Mordant, Arnaud Roussel, Fathia Mami‐Chouaib, Fatima Mechta‐Grigoriou, Gérard Zalcman, Fabrice Soncin, Stéphanie Descroix, Maria Carla Parrini   +16 more
wiley   +1 more source

Drug Delivery in Plants Using Silk Microneedles

Advances in Materials, 2022
New systems for agrochemical delivery in plants will foster precise agricultural practices and provide new tools to study plants and design crop traits, as standard spray methods suffer from elevated loss and limited access to remote plant tissues.
Yunteng Cao, Sally Shuxian Koh, Yangyang Han, Javier Jingheng Tan, Doyoon Kim, N. Chua, D. Urano, B. Marelli   +7 more
semanticscholar   +1 more source

Advanced modification of drug nanocrystals by using novel fabrication and downstream approaches for tailor-made drug delivery [PDF]

, 2019
Drug nanosuspensions/nanocrystals have been recognized as one useful and successful approach for drug delivery. Drug nanocrystals could be further decorated to possess extended functions (such as controlled release) and designed for special in vivo ...
Haipeng, Yin, Liu, Tao, Möschwitzer, Jan P., Xinxin, Yu   +3 more
core   +1 more source

Delivery of Islatravir via High Drug‐Load, Long‐acting Microarray Patches for the Prevention or Treatment of Human Immunodeficiency Virus

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
Islatravir‐loaded dissolving microarray patches (MAPs) provide a minimally invasive, long‐acting solution for HIV‐1 prevention and treatment. In rats, sustained islatravir delivery lasts up to three months, while in minipigs, efficacious plasma levels are detected for six days.
Qonita Kurnia Anjani, Ashley R. Johnson, Akmal H. Sabri, Ryan Lutz, Steven Tignor, Jeanine Ballard, Nathan Rudd, Li Zhao, Lalitkumar K. Vora, Stephanie E. Barrett, Angela Wagner, Ryan F. Donnelly   +11 more
wiley   +1 more source

Towards pain-free diagnosis of skin diseases through multiplexed microneedles: biomarker extraction and detection using a highly sensitive blotting method [PDF]

, 2015
Immunodiagnostic microneedles provide a novel way to extract protein biomarkers from the skin in a minimally invasive manner for analysis in vitro.
A Bhargav, AA Ansari, AV Romanyuk, B Yeow, C Ericsson, CG Li, DA Muller, DV McAllister, G Gremel, HS Gill, JM Skehel, JR Lakowicz, JW Coffey, KT Lee, L Fuertes, L Fuertes, LM Strambini, LM Strambini, M Pilar Martin Del, MI Haq, N Cai, NC Shaner, RF Donnelly, SM Bal, SR Corrie, T-M Tuan-Mahmood, W Schramm, Y Zhu, Y-C Kim   +28 more
core   +2 more sources

Smart Polymeric 3D Microscaffolds Hosting Spheroids for Neuronal Research via Quantum Metrology

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
Development of a platform consisting of 3D microscaffolds supporting 3D embryoid bodies for neuronal research. The polymeric scaffolds enable directed growth of neurites. This study shows nanodiamond‐based quantum sensors graft onto the polymer material, enabling quantum metrology experiments within the 3D neuronal model and thereby providing a ...
Beatriz N. L. Costa, Ana Marote, Catarina Barbosa, Jonas Campos, António J. Salgado, Jana B. Nieder   +5 more
wiley   +1 more source

Implantable Silk Composite Microneedles for Programmable Vaccine Release Kinetics and Enhanced Immunogenicity in Transcutaneous Immunization [PDF]

, 2013
Microneedle vaccines mimic several aspects of cutaneous pathogen invasion by targeting antigen to skin-resident dendritic cells and triggering local inflammatory responses in the skin, which are correlated with enhanced immune responses.
Bachmann, Chen, Chen, del Pilar Martin, DeMuth, DeMuth, DeMuth, DeMuth, Gray, Gross, Jewell, Johansen, Kim, Kim, Koutsonanos, Lanford, Levine, Lin, Mueller, Nestle, Numata, Pritchard, Reetoo, Rockwood, Sallusto, Shaulov, Stahl-Hennig, Tseng, Tsioris, Turner, Wenk, Woodland, You, Yue, Zammit, Zhang   +35 more
core   +1 more source

MICRONEEDLE: AN OVERVIEW

, 2022
The most frequent modalities for transdermal medication administration include hypodermic needles, topical creams, and transdermal patches. Because the stratum corneum layer of the skin functions as a barrier for molecules, only a few molecules reach the site of action, most therapeutic medications have a limited effect. This page discusses the various
openaire   +1 more source

Microvascular effects of microneedle application

Skin Research and Technology, 2020
AbstractBackgroundThe efficiency of transdermal drug delivery may be increased by pretreating the skin with microneedles, but distinct effects of microneedles and the microneedle‐enhanced delivery of vasoactive drugs on the skin microvasculature are still not well investigated.Materials and MethodsIn eight healthy human subjects, we measured the ...
Johannes Hackethal, Fredrik Iredahl, Joakim Henricson, Chris D. Anderson, Erik Tesselaar   +4 more
openaire   +5 more sources

Gasotransmitters in Modern Medicine: Promises and Challenges in the Use of Porous Crystalline Carriers

Advanced Healthcare Materials, EarlyView.
This perspective provides an overview of the growing interest in utilizing various gasotransmitters—small gaseous signaling molecules namely nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)—for several therapeutic applications, with emphasis on the potential use of porous materials as carriers to provide safe and controlled local ...
Rosana V. Pinto, Moisés L. Pinto, Christian Serre   +2 more
wiley   +1 more source