Results 281 to 290 of about 13,726,259 (365)

Micronucleus Test Reveals Genotoxic Effects in Bats Associated with Agricultural Activity

Environmental Toxicology and Chemistry, 2020
Bats play a vital role in our ecosystems and economies as natural pest‐control agents, seed dispersers, and pollinators. Agricultural intensification, however, can impact bats foraging near crops, affecting the ecosystem services they provide.
N. Sandoval-Herrera, Jesusa Paz Castillo, L. G. Herrera Montalvo, Kenneth C Welch   +3 more
semanticscholar   +1 more source

Development of a novel flow cytometry‐based approach for reticulocytes micronucleus test in rat peripheral blood

Journal of Applied Toxicology, 2020
The micronucleus test (MNT) is the most widely applied short‐term assay to detect clastogens or spindle disruptors. The use of flow cytometry (FCM) has been reported for micronucleated erythrocytes scoring in peripheral blood.
Yiyi Chen, Jiao Huo, Yunjie Liu, Zhu Zeng, Xuejiao Zhu, Xuxi Chen, Rui Wu, Lishi Zhang, Jin-yao Chen   +8 more
semanticscholar   +1 more source

Sampling times in micronucleus testing

Mutation Research Letters, 1992
A series of micronucleus inducers were evaluated in the mouse bone marrow micronucleus test to determine if a 72-h sampling time enhances the sensitivity for detecting genotoxic agents. Male and female Swiss albino mice were dosed once with 7,12- dimethylbenz[a]anthracene, 6-mercaptopurine, benzo[a]pyrene, benzene, cyclophosphamide, 2 ...
P, Vanparys, G, Deknudt, F, Vermeiren, M, Sysmans, R, Marsboom   +4 more
openaire   +2 more sources

The micronucleus test methodological aspects

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1973
Abstract Changes in the cellular compositiion of bone marrow were studied in relation to dose of Trenimon® and time after treatment. Strong mutagenic effects caused a partial depletion of the marrow cavities of nucleated blood cell precursors, with subsequent retention of newly formed erythrocytes and inundation with peripheral blood.
Von Ledebur, M, Schmid, Werner
openaire   +2 more sources

The automated bone marrow micronucleus test

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1989
A new technology is presented which offers high-quality slides enabling the fully automated scoring of large quantities of erythrocytic cells for micronuclei by computerized image analysis. The techniques are applicable to bone marrow specimens as well as to peripheral blood obtained from various species of laboratory animals as well as from man.
F, Romagna, C D, Staniforth
openaire   +2 more sources

Statistical analysis of the micronucleus test

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1984
Various statistical procedures are discussed to compare the incidence of micronucleated polychromatic erythrocytes between various treatment groups and a negative control. The effect of toxicity on the choice of statistical procedure is discussed. The procedure which is recommended is based on likelihood ratio tests comparing each dose group separately
G E, Amphlett, G F, Delow
openaire   +2 more sources

Effect of erythropoietin on the micronucleus test

Environmental and Molecular Mutagenesis, 1989
AbstractThe micronucleus test is used widely as an in vivo short‐term assay for potential carcinogens. In the present study, results of the micronucleus test were affected by the rate of erythropoiesis in the bone marrow erythropoietin, a growth factor for the erythroblast, which was used to induce erythropoiesis.The highest frequency of micronucleated
Y, Suzuki, Y, Nagae, T, Ishikawa, Y, Watanabe, T, Nagashima, K, Matsukubo, H, Shimizu   +6 more
openaire   +2 more sources

The micronucleus test with mouse spleen cells

Mutation Research Letters, 1983
The results of this study show that the micronucleus test can be carried out with mouse spleen cells as well as with cells from bone marrow. Polychromatic erythrocytes occurred in the spleen at a frequency of about 9% of the whole spleen cells compared with about 13% in the bone marrow. 3 test compounds were used to compare the frequency of micronuclei
Y, Shindo, F, Hirano, H, Maeda, U, Takeda   +3 more
openaire   +2 more sources

The micronucleus test in piscine erythrocytes

Aquatic Toxicology, 2006
Cytogenetic assays on aquatic organisms are essential, as humans are exposed throughout their lifetime to several xenobiotics present in both the water and aquatic food. The micronucleus test showed to be a useful in vivo assay for genotoxicity testing. However, many aspects of its protocol need to be refined, knowledge of confounding factors should be
openaire   +2 more sources

The micronucleus test: Statistical design and analysis

Mutation Research/Environmental Mutagenesis and Related Subjects, 1979
Alternative statistical procedures are discussed which may be employed to compare the incidences among treatment groups of micronucleated polychromatic and normochromatic erythrocytes and their ratios. Comparison of incidences of micronucleated polychromatic erythrocytes using a sequential sampling strategy based on the negative binomial distribution ...
B E, Mackey, J T, MacGregor
openaire   +2 more sources