Results 51 to 60 of about 46,424 (265)

Magnetoactive Hydrogels to Probe Curvature‐Directed Endothelial Cell Mechanosensing

Advanced Healthcare Materials, EarlyView.
This work establishes a platform to investigate local curvature as a regulator of endothelial mechanosensing independent of shear stress. Magnetoactive hydrogels enable on‐demand curvature of endothelial monolayers to reproduce tortuosity quantified by clinically established metrics.
Avinava Roy, Grace K. Hinds, Joshua Yu‐Chung Liu, Ziqian Yang, Rishab Yanala, Arina E. Velieva, Claudia Loebel   +6 more
wiley   +1 more source

Synthetic Biodegradable Microparticle and Nanoparticle Vaccines against the Respiratory Syncytial Virus

Vaccines, 2016
Synthetic biodegradable microparticle and nanoparticle platform technology provides the opportunity to design particles varying in composition, size, shape and surface properties for application in vaccine development.
Patricia A. Jorquera, Ralph A. Tripp
doaj   +1 more source

Bone Organoids Across the Development‐to‐Remodeling Continuum: From Tissue Formation to Functional Competence and Translation

Advanced Healthcare Materials, EarlyView.
Mineralization alone does not establish a mature bone organoid. This Review integrates biological foundations, materials design, adaptive remodeling, and translational validation through the development‐to‐remodeling continuum (DRC). By separating biological functions from the evidence supporting them, the framework exposes critical gaps in current ...
Xijie Tang, Haijia Xu, Xiangzhong Liu, Yi Yang, Zhanghua Li   +4 more
wiley   +1 more source

Design of Experiment (DoE) Approach for Developing Inhalable PLGA Microparticles Loaded with Clofazimine for Tuberculosis Treatment

Pharmaceuticals
Tuberculosis (TB) is an airborne bacterial infection caused by Mycobacterium tuberculosis (M. tb), resulting in approximately 1.3 million deaths in 2022 worldwide.
Druva Sarika Rongala, Suyash M. Patil, Nitesh K. Kunda   +2 more
doaj   +1 more source

Neuronal Uptake of Nano‐Sized PMMA Orthopedic Wear Particles in a Compartmentalized Microfluidic Model Revealed by Label‐Free Confocal Raman Microscopy

Advanced Healthcare Materials, EarlyView.
Nano‐sized orthopedic implant‐derived particles interact with sensory neurons, with poly(methyl methacrylate) (PMMA)‐associated signal detected in neuronal somata following selective axonal exposure in compartmentalized microfluidic cultures. Label‐free confocal Raman microscopy provides complementary chemical evidence of PMMA‐associated material in ...
Marina Couto, Ana Carolina Monteiro, Maria Gomez‐Lazaro, Cristina Ribeiro, Estrela Neto, Daniela Pereira de Vasconcelos, Meriem Lamghari   +6 more
wiley   +1 more source

Microparticles engineered to highly express peroxisome proliferator-activated receptor-γ decreased inflammatory mediator production and increased adhesion of recipient monocytes.

PLoS ONE, 2014
Circulating blood microparticles are submicron vesicles released primarily by megakaryocytes and platelets that act as transcellular communicators.
Julie Sahler, Collynn F Woeller, Richard P Phipps   +2 more
doaj   +1 more source

Leaftronics: Bio‐Fractal Scaffolds From Leaf Venation for Low‐Waste Electronics

Advanced Materials, EarlyView.
“Leaftronics” transforms naturally evolved leaf venation into quasi‐fractal scaffolds for sustainable electronics. Polymer‐infiltrated leaf skeletons can be used to fabricate ultra‐smooth, reflow‐ and thin‐film‐compatible decomposable substrates, while making the same lignocellulose networks conducting results in flexible transparent electrodes.
Rakesh Rajendran Nair, Hrisheekesh Thachoth Chandran, Karl Leo, Hans Kleemann   +3 more
wiley   +1 more source

Can Elastomers Combine Stiffness, Toughness and Fatigue Resistance?

Advanced Materials, EarlyView.
This review studies how the molecular and macroscopic architecture of elastomers influence their mechanical properties including: stiffness, stretchability, toughness, fatigue resistance, and damping behavior. By linking the structure to performance, it proposes design principles for advanced elastomeric systems that combine mechanical properties ...
Eva Baur, Esther Amstad
wiley   +1 more source

Radiative Thermal Management for Extreme Environments: Mechanisms and Design Strategies

Advanced Materials, EarlyView.
In this review, we discuss the fundamental mechanisms of radiative cooling and solar heating, material and structural design strategies, hybrid approaches integrating additional heat transfer pathways, and durability‐oriented designs addressing environmental stresses.
Hyung Rae Kim, Haeseong Kim, Joo Hwan Ko, Gil Ju Lee, Dae‐Hyeong Kim, Young Min Song   +5 more
wiley   +1 more source

Programmable Microgel Degradation in Dynamic Granular Hydrogels Guides Extracellular Matrix Assembly During Tissue Repair

Advanced Materials, EarlyView.
This study reports on the chemical modification of hyaluronic acid to create hydrogels with hydrolytic degradability ranging from 2–28 days. Granular hydrogels that undergo timed degradation to increase porosity enhance cell invasion and provisional ECM remodeling in a muscle injury model, leading to reduced fibrosis and improved regeneration ...
Zhiyuan Chen, Tuba Marjan, Xinyue Lu, Nicole E. Mertens, Keira Vesy, Dean E. Stornello, James F. Markworth, Taimoor H. Qazi   +7 more
wiley   +1 more source