Results 161 to 170 of about 24,554,140 (185)

Developing Liver Microphysiological Systems for Biomedical Applications

Advanced Healthcare Materials, 2023
AbstractMicrophysiological systems (MPSs), also known as organ chips, are micro‐units that integrate cells with diverse physical and biochemical environmental cues. In the field of liver MPSs, cellular components have advanced from simple planar cell cultures to more sophisticated 3D formations such as spheroids and organoids. Additionally, progress in
Jinglin Wang, Xiangyi Wu, Junqi Zhao, Haozhen Ren, Yuanjin Zhao   +4 more
openaire   +2 more sources

Microfluidic-based vascularized microphysiological systems

Lab on a Chip, 2018
Microphysiological systems have emerged in the last decade to provide an alternative to in vivo models in basic science and pharmaceutical research.
Somin Lee, Jihoon Ko, Dohyun Park, Seung-Ryeol Lee, Minhwan Chung, Younggyun Lee, Noo Li Jeon   +6 more
openaire   +2 more sources

Microphysiological systems of the placental barrier

Advanced Drug Delivery Reviews, 2020
Methods to evaluate maternal-fetal transport across the placental barrier have generally involved clinical observations after-the-fact, ex vivo perfused placenta studies, or in vitro Transwell assays. Given the ethical and technical limitations in these approaches, and the drive to understand fetal development through the lens of transport-induced ...
Navein, Arumugasaamy, Kylie D, Rock, Che-Ying, Kuo, Tracy L, Bale, John P, Fisher   +4 more
openaire   +2 more sources

Vascular microphysiological systems (MPS): biologically relevant and potent models.

Lab on a Chip
Extensive research has focused on the vasculature, aiming to understand its structural characteristics, functions, interactions with surrounding tissues, and the mechanisms underlying vascular-related pathologies.
Lucas Breuil, Atsuya Kitada, Sachin Yadav, Hang Zhou, Kazuya Fujimoto, Ryuji Yokokawa   +5 more
semanticscholar   +1 more source

Human microphysiological systems for drug development

Science, 2021
Organs-on-chips could be used to assess drug efficacy and support personalized ...
openaire   +2 more sources

Microphysiological Systems in Cancer Research: Advancing Immunotherapy through Tumor Microenvironment‐Integrated Organ‐On‐Chip Models

Advances in Therapy
The intricate tumor microenvironment (TME) poses a significant barrier to effective cancer immunotherapy, requiring innovative strategies to model and address its challenges.
Fabiana Moresi, F. Noto, Jyothsna Vasudevan, Xavier Bisteau, Giulia Adriani, Andrea Pavesi   +5 more
semanticscholar   +1 more source

Biologically-Inspired Microphysiological Systems

2019
Microphysiological multi-organ devices are designed to mimic the physiological interaction of various interconnected organ models, by successfully imitating organismal functionality and response to substances. The first concepts of in vitro multi-organ systems were put forward in the late 1980s, demonstrating that such systems could provide mechanistic
Dehne, Eva Maria, Hickman, James, Shuler, Michael   +2 more
openaire   +2 more sources

Advances in TEER measurements of biological barriers in microphysiological systems.

Biosensors & bioelectronics, 2023
Biological barriers are multicellular structures that precisely regulate the transport of ions, biomolecules, drugs, cells, and other organisms. Transendothelial/epithelial electrical resistance (TEER) is a label-free method for predicting the properties
H. Nazari, J. Shrestha, V. Y. Naei, S. R. Bazaz, Milad Sabbagh, J. Thiery, M. Warkiani   +6 more
semanticscholar   +1 more source

Advanced in vitro evaluation of drug-induced kidney injury using microphysiological systems in drug discovery and development.

Drug Metabolism and Pharmacokinetics
Drug-induced kidney injury (DIKI) is a major cause of acute kidney injury (AKI). Given concerns about animal welfare and the need for more accurate prediction of human events, there is an urgent need to develop an in vitro evaluation method for DIKI ...
Hiroshi Arakawa, Kohei Matsushita, Naoki Ishiguro   +2 more
semanticscholar   +1 more source

From animal testing to in vitro systems: advancing standardization in microphysiological systems.

Lab on a Chip
Limitations with cell cultures and experimental animal-based studies have had the scientific and industrial communities searching for new approaches that can provide reliable human models for applications such as drug development, toxicological ...
Darwin R. Reyes, Mandy B Esch, Lorna Ewart, Rohollah Nasiri, Anna Herland, K. Sung, M. Piergiovanni, Carolina Lucchesi, James T Shoemaker, Jelena Vukasinovic, H. Nakae, J. Hickman, K. Pant, Anne Taylor, Niki Heinz, Nureddin Ashammakhi   +15 more
semanticscholar   +1 more source