Results 201 to 210 of about 282,025 (323)

Progress in research on osteoporosis secondary to SARS‐CoV‐2 infection

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This review explores the potential mechanisms, complications, risk factors, and future research directions related to osteoporosis secondary to SARS‐CoV‐2 infection. Key mechanisms include an imbalance between osteoclast and osteoblast activity driven by direct viral effects on bone, inflammation, hypoxia, dysregulation of noncoding RNAs, and metabolic
Jinlong Wang   +5 more
wiley   +1 more source

A companion to the preclinical common data elements for genomics, transcriptomics, and epigenomics data in rodent epilepsy models. A report of the TASK3‐WG4 omics working group of the ILAE/AES joint translational TASK force

open access: yesEpilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various preclinical epilepsy research disciplines. The aim of the CDEs is to improve the standardization of experimental designs across a range of epilepsy ...
Erwin A. van Vliet   +11 more
wiley   +1 more source

Transplanting neural stem cells overexpressing miRNA‐21 can promote neural recovery after cerebral hemorrhage through the SOX2/LIN28‐let‐7 signaling pathway

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Abstract Background Intracerebral hemorrhage (ICH) remains a devastating neurological disorder with limited therapeutic options. Neural stem cell (NSC)‐based therapies have emerged as a potential regenerative approach, yet the molecular mechanisms regulating NSC behavior require further elucidation.
Wei Dai   +7 more
wiley   +1 more source

Structural Features of MicroRNA (miRNA) Precursors and Their Relevance to miRNA Biogenesis and Small Interfering RNA/Short Hairpin RNA Design [PDF]

open access: hybrid, 2004
Jacek Król   +6 more
openalex   +1 more source

Krüppel‐like factor 4 transcription factor in blood–brain barrier endothelial cells: A potential role in Alzheimer's disease

open access: yesAnimal Models and Experimental Medicine, EarlyView.
KLF4 (Krüppel‐like factor 4) plays a protective role in blood–brain barrier (BBB). KLF4 plays an ambiguous role in the central nervous system. KLF4 in the BBB endothelial cells could be a potential target for Alzheimer's disease. Abstract Alzheimer's disease is the most prevalent chronic neurodegenerative disorder worldwide, with no sufficient cure ...
Ziying Wei   +4 more
wiley   +1 more source

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