Results 221 to 230 of about 245,684 (269)

MicroRNAs

The Cancer Journal, 2008
MicroRNAs (miRNAs) are small, noncoding RNAs with regulatory functions, which play an important role in many human diseases, including cancer. An emerging number of studies show that miRNAs can act either as oncogenes or as tumor suppressor genes or sometimes as both. Germline, somatic mutations and polymorphisms can contribute to cancer predisposition.
Muller, Fabbri   +2 more
openaire   +2 more sources

MicroRNAs Regulating MicroRNAs in Cancer

Trends in Cancer, 2018
MicroRNAs (miRNA) are capable of self-regulation, termed miRNA to miRNA interaction. Very little is known about these interactions and their impact on the cellular milieu. We discuss known miRNA to miRNA interactions, potential mechanisms, and their role in cancer.
Meredith, Hill, Nham, Tran
openaire   +2 more sources

The MicroRNA

2012
MicroRNAs (miRNAs), widely distributed, small regulatory RNA genes, target both messenger RNA (mRNA) degradation and suppression of protein translation based on sequence complementarity between the miRNA and its targeted mRNA. Different names have been used to describe various types of miRNA. During evolution, RNA retroviruses or transgenes invaded the
Shao-Yao, Ying   +2 more
openaire   +3 more sources

Participation of microRNAs in human interactome: extraction of microRNA–microRNA regulations

Molecular BioSystems, 2011
Abstract To date, a significant amount of research has been conducted for computational modeling of the microRNA(miRNA)-targetgene interactions and inferring different kinds of biologically relevant association from their variable expressions, available from microarray experiments.
Debarka, Sengupta   +1 more
openaire   +2 more sources

MicroRNA Targeting

2021
MicroRNAs (miRNAs) are small noncoding elements that play essential roles in the posttranscriptional regulation of biochemical processes. miRNAs recognize and target multiple mRNAs; therefore, investigating miRNA dysregulation is an indispensable strategy to understand pathological conditions and to design innovative drugs. Targeting miRNAs in diseases
Hossein, Ghanbarian   +2 more
openaire   +2 more sources

RARs and MicroRNAs

2014
MicroRNA MicroRNA s (miRNAs) are small noncoding RNAs acting as endogenous regulators of gene expression. Their discovery is one of the major recent breakthroughs in molecular biology. miRNAs establish a multiplicity of relationships with target mRNAs and exert pleiotropic biological effects in many cell physiological pathways during development and ...
Nervi, Clara, GRIGNANI, Francesco
openaire   +3 more sources

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