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The MicroRNA

2012
MicroRNAs (miRNAs), widely distributed, small regulatory RNA genes, target both messenger RNA (mRNA) degradation and suppression of protein translation based on sequence complementarity between the miRNA and its targeted mRNA. Different names have been used to describe various types of miRNA. During evolution, RNA retroviruses or transgenes invaded the
Shao-Yao, Ying   +2 more
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RARs and MicroRNAs

2014
MicroRNA MicroRNA s (miRNAs) are small noncoding RNAs acting as endogenous regulators of gene expression. Their discovery is one of the major recent breakthroughs in molecular biology. miRNAs establish a multiplicity of relationships with target mRNAs and exert pleiotropic biological effects in many cell physiological pathways during development and ...
Nervi, Clara, GRIGNANI, Francesco
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MicroRNAs in Cancer.

Annual Review of Medicine, 2009
MicroRNAs (miRNAs) are small, noncoding RNAs with important functions in development, cell differentiation, and regulation of cell cycle and apoptosis. MiRNA expression is deregulated in cancer by a variety of mechanisms including amplification, deletion,
R. Garzon, G. Calin, C. Croce
semanticscholar   +1 more source

Participation of microRNAs in human interactome: extraction of microRNA–microRNA regulations

Molecular BioSystems, 2011
To date, a significant amount of research has been conducted for computational modeling of the microRNA (miRNA)-target gene interactions and inferring different kinds of biologically relevant association from their variable expressions, available from microarray experiments.
Debarka Sengupta   +1 more
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Evolution of MicroRNAs

2006
MicroRNAs (miRNAs) form a large class of small regulatory RNAs in eukaryotes. Although they share a common processing pathway and certain structural features, in general, there is no detectable sequence similarity among miRNAs from a given organism. On the other hand, many miRNAs are members of a family of a few, often very similar, paralogs.
Andrea Tanzer, Peter F. Stadler
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An overview of microRNAs: Biology, functions, therapeutics, and analysis methods

Journal of Cellular Physiology, 2018
MicroRNAs (miRNAs) are a class of small noncoding RNAs, which function in posttranscriptional regulation of gene expression. They are powerful regulators of various cellular activities including cell growth, differentiation, development, and apoptosis ...
K. Saliminejad   +3 more
semanticscholar   +1 more source

MicroRNAS and their regulatory roles in plants.

Annual Review of Plant Biology, 2006
MicroRNAs (miRNAs) are small, endogenous RNAs that regulate gene expression in plants and animals. In plants, these approximately 21-nucleotide RNAs are processed from stem-loop regions of long primary transcripts by a Dicer-like enzyme and are loaded ...
M. Jones-Rhoades, D. Bartel, B. Bartel
semanticscholar   +1 more source

microRNAs in Inflammation

International Reviews of Immunology, 2009
microRNAs are small noncoding RNAs that regulate protein-coding genes via posttranscriptional repression. Most protein-coding genes are subjected to microRNA-mediated regulation, making the potential effect of these small molecules on regulatory networks enormous.
Andor Pivarcsi, Enikö Sonkoly
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MicroRNA and implantation

Fertility and Sterility, 2014
We provide a review of microRNA (miRNA) related to human implantation which shows the potential diagnostic role of miRNAs in impaired endometrial receptivity, altered embryo development, implantation failure after assisted reproduction technology, and in ectopic pregnancy and pregnancies of unknown location. MicroRNAs may be emerging diagnostic markers
Antonio Pellicer, Daniela Galliano
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MicroRNAs in the hypothalamus

Best Practice & Research Clinical Endocrinology & Metabolism, 2016
The brain is considered a major site for microRNA (miRNA) expression; as evidenced by several studies reporting microarray data of different brain substructures. The hypothalamus is among the brain regions that plays a crucial role in integrating signals from other brain nuclei as well as environmental, hormonal, metabolic and neuronal signals from the
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