Results 91 to 100 of about 137,024 (324)

Deep Learning based Prediction of MSI using MMR Markers in Colorectal Cancer [PDF]

arXiv, 2022
The accurate diagnosis and molecular profiling of colorectal cancers are critical for planning the best treatment options for patients. Microsatellite instability (MSI) or mismatch repair (MMR) status plays a vital role in appropriate treatment selection, has prognostic implications and is used to investigate the possibility of patients having ...
arxiv  

Characterization of microsatellite markers in cassava based on microsatellite-AFLP technique [PDF]

Genetics and Molecular Research, 2012
We developed molecular markers for cassava based on the microsatellite-amplified fragment length polymorphism (M-AFLP) technique. Twenty primer pairs were developed and used for the analysis of 48 samples of Manihot species, consisting of M. esculenta (33), M. esculenta ssp flabellifolia (3), M. chlorosticta (3), M.
Kanokporn Triwitayakorn, Ratchadaporn Thaikert, Sukhuman Whankaew, Duncan R. Smith, Supajit Sraphet   +4 more
openaire   +2 more sources

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source

Development of microsatellite markers for the characterisation of Phaeoisariopsis griseola (bean angular leaf spot agent) populations in Central America

Plant Protection Science, 2002
Although several researches revealed an important diversity within Phaeoisariopsis griseola, the bean angular leaf spot (ALS) agent, no sexual recombination was already detected for this fungus.
J.P. Busogoro, O. Duterme, P. Lepoivre
doaj   +1 more source

A Copper‐Based Photothermal‐Responsive Nanoplatform Reprograms Tumor Immunogenicity via Self‐Amplified Cuproptosis for Synergistic Cancer Therapy

Advanced Science, EarlyView.
This study introduces cuproptosis nanoplatform, a novel nanoplatform using Cu2−XS hollow nanospheres, elesclomol, and lauric acid (LA) for self‐amplified cuproptosis. NIR‐II laser activation melts LA, releasing copper ions and elesclomol to enhance copper delivery within tumor cells, reduce glutathione's inhibitory effect, and trigger immunogenic cell ...
Runzi Cheng, Zhenhao Li, Weican Luo, Hongwu Chen, Tingting Deng, Zhenqi Gong, Qing Zheng, Baizhi Li, Yongming Zeng, Huaiming Wang, Cong Huang   +10 more
wiley   +1 more source

Genetic Characterization of Cleveland Bay Horse Breed

Diversity, 2019
The Cleveland Bay (CB) is the United Kingdom’s oldest established horse breed. In this study we analyzed the genetic variability in CB horses and investigated its genetic relationships with other horse breeds.
Anas M. Khanshour, Eleanore K. Hempsey, Rytis Juras, E. Gus Cothran   +3 more
doaj   +1 more source

Development and Validation of a Deep Learning-Based Microsatellite Instability Predictor from Prostate Cancer Whole-Slide Images [PDF]

arXiv, 2023
Microsatellite instability-high (MSI-H) is a tumor agnostic biomarker for immune checkpoint inhibitor therapy. However, MSI status is not routinely tested in prostate cancer, in part due to low prevalence and assay cost. As such, prediction of MSI status from hematoxylin and eosin (H&E) stained whole-slide images (WSIs) could identify prostate cancer ...
arxiv  

Methionine Metabolism Dictates PCSK9 Expression and Antitumor Potency of PD‐1 Blockade in MSS Colorectal Cancer

Advanced Science, EarlyView.
xxxx. Abstract Nutrient metabolisms are vitally interrelated to cancer progression and immunotherapy. However, the mechanisms by which nutrient metabolisms interact to remodel immune surveillance within the tumor microenvironment remain largely unexplored.
Qi‐Long Wang, Zijie Chen, Xiaofei Lu, Huizhen Lin, Huolun Feng, Nuozhou Weng, Liwen Chen, Mengnan Liu, Li Long, Lingjun Huang, Yongmei Deng, Kehong Zheng, Xiaojun Zheng, Yong Li, Ting Cai, Jiabin Zheng, Wei Yang   +16 more
wiley   +1 more source

Clinical significance of preoperative Glasgow prognostic score in patients with colorectal cancer and synchronous peritoneal metastases

Annals of Gastroenterological Surgery, EarlyView.
Preoperative GPS2 is an independent poor prognostic factor in patients with colorectal cancer and synchronous peritoneal metastases, and surgical resection does not improve prognosis in patients with GPS2. Preoperative GPSs may be used as indicators for surgical resection of synchronous peritoneal metastases.
Kosuke Fujimoto, Fumikazu Koyama, Hirotoshi Kobayashi, Kenjiro Kotake, Masayasu Kawasaki, Yukihide Kanemitsu, Yusuke Kinugasa, Hideki Ueno, Kotaro Maeda, Takeshi Suto, Michio Itabashi, Kimihiko Funahashi, Heita Ozawa, Shingo Noura, Hideyuki Ishida, Masayuki Ohue, Tomomichi Kiyomatsu, Soichiro Ishihara, Keiji Koda, Hideo Baba, Kenji Kawada, Yojiro Hashiguchi, Takanori Goi, Yuji Toiyama, Naohiro Tomita, Eiji Sunami, Fumihiko Fujita, Jun Watanabe, Kenichi Hakamada, Goro Nakayama, Kenichi Sugihara, Yoichi Ajioka   +31 more
wiley   +1 more source

Comparative population genetic structure and demographic patterns of two killifish species (Aphanius baeticus and Aphanius iberus) at the Iberian Peninsula

Frontiers in Marine Science, 2015
The killifish, Aphanius baeticus and Aphanius iberus (Cyprinodontidae) are endemic species restricted to river basins on Spain’s southern Atlantic and Mediterranean coastline, respectively.
Elena G Gonzalez, Francisco Oliva-Paterna   +1 more
doaj   +1 more source