Results 131 to 140 of about 197,028 (259)
Med Research, EarlyView.This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang +4 more
wiley +1 more source
The Journal of Pathology, EarlyView.Abstract Ductular reactions (DRs) are dynamic and complex multicellular responses that occur as a result of various hepatic injuries. Precise identification and quantification of the extent of DRs is a cornerstone of pre‐clinical modelling of liver disease, with links to inflammation, fibrosis, regeneration, and disease severity.
Nathalie Feeley +15 more
wiley +1 more source
The Journal of Pathology, EarlyView.Abstract Fibroblast growth factor receptor 1 (FGFR1) amplification, a significant cancer alteration with both prognostic and therapeutic relevance, lacks a standardized definition. The relationship between FGFR1 copy number (CN) variations and tumour microenvironment (TME) characteristics also remains poorly understood.
Yike Gao +6 more
wiley +1 more source
Management and incipient domestication of Chamaedorea tepejilote in agroforestry systems in Mexico
PLANTS, PEOPLE, PLANET, EarlyView.Native wild plants are key elements in addressing global biodiversity loss and supporting sustainable food systems. We investigated how rural communities in Mexico manage Chamaedorea tepejilote, a wild palm with edible male inflorescences, by combining ethnobotanical, genetic, morphological and ecological approaches.
Viviana Andrade +7 more
wiley +1 more source
PLANTS, PEOPLE, PLANET, EarlyView.Plant hybridization is increasingly recognized as an important evolutionary process, and a deeper understanding of hybridization is necessary for its application to agriculture, conservation, and ecological solutions. Here, we assess correlates of hybridization in the megadiverse and societally important family Asteraceae and how and where hybrids have
Leandra O′Connell +2 more
wiley +1 more source
Needle in a haystack: Holocene history of European larch in Central Europe revisited
PLANTS, PEOPLE, PLANET, EarlyView.Defining nativity of species is crucial for their management. However, this is a complex task, especially for species that have been used and spread by humans for a long time. We combined paleoecological records with extensive genetic data to investigate the Holocene history of European larch—a common and economically important tree species in Central ...
Martin Prach +11 more
wiley +1 more source
Precision Medical Sciences, EarlyView.The translational pipeline of precision medicine in clinical oncology. Schematic overview of the individualized cancer care workflow. (1) Input: Patient samples undergo multi‐omic profiling via NGS, single‐cell diagnostics, spatial maps, and epigenetic sequencing.
Asif Jan +3 more
wiley +1 more source
Pest Management Science, EarlyView.This article reports the first genome sequence of a UK Alternaria brassicae isolate. Dual RNA‐sequencing profiling of A. brassicae‐infected Brassica juncea leaves identified differentially expressed genes involved in pathogenicity and host response pathways in moderately resistant Sej‐2 (2) and moderately susceptible Pusa Jaikisan cultivars.
Kevin M. King +6 more
wiley +1 more source
Pest Management Science, EarlyView.Transcriptome sequencing of Ceutorhynchus obstrictus revealed RNA interference (RNAi) targets; double‐stranded RNA microinjection reduced transcript levels and increased mortality, with αCOP and Rop showing strongest lethal effects, indicating promising RNAi‐based pest control candidates.
Apurva Vikas Sabnis +8 more
wiley +1 more source