Results 141 to 150 of about 197,028 (259)

Medullary colon carcinoma with microsatellite instability: case report

Colorectal cancer is the third most common neoplasm and the second most lethal worldwide. The most common histological type is adenocarcinoma, characterized by its glandular pattern.
Mariana Macambira Noronha, Leonardo Saraiva Pontes, Gabriel Sampaio Feitosa, Mayra Wilma Martins Cardoso Soares, Igor Santos Costa, José Walter Feitosa Gomes, Elam Vasconcelos de Aquino   +6 more
core   +1 more source

The first report of M918L (super‐kdr) and L932F voltage‐gated sodium channel mutations in the English grain aphid (Sitobion avenae)

Pest Management Science, EarlyView.
The study has identified mutations in the voltage gated sodium channel of the English grain aphid (Sitobion avenae) at M918 and L932, which have not been previously reported in this species. Abstract BACKGROUND The grain aphid, Sitobion avenae Fabricius (Hemiptera: Aphididae), is a vector of yellow dwarf viruses and an important pest of cereals.
Virgile Ballandras, Louise McNamara, James C Carolan, Tom Ruttink, Stephen Byrne   +4 more
wiley   +1 more source

A New Clinical Paradigm: Stratified Gut Microbiota Interventions to Enhance Efficacy and Attenuate Toxicity of Cancer Immunotherapy

Microbiota Medicine Research, EarlyView.
Liang Zhang, Xinyu Du, Lijuan Sun, Ziyi Shi, Yongzhan Nie   +4 more
wiley   +1 more source

Identification of Active Compounds of Centipeda minima for Potentiating Tumor Immunotherapy in Non‐Small Cell Lung Cancer via FANCD2‐cGAS/STING/IFN‐I Signaling Axis

Phytotherapy Research, EarlyView.
Schematic diagram illustrating the underlying mechanisms by which ECM and its active components activate the FANCD2‐cGAS/STING/IFN‐I signaling axis, thus enhancing the therapeutic efficacy of anti‐PD‐1 in NSCLC. ABSTRACT Activation of cGAS/STING/IFN‐I signaling pathway serves as a potential therapeutic strategy to enhance CD8+ T cells infiltration and ...
Han‐Chen Wang, Chu‐Ying Chen, Jiang‐Tao Xiao, Rou‐Qiao Zheng, Wen‐Da He, Zi‐Wei Xu, Su‐Fen Wei, Tao Su, Guang‐Biao Zhou, Yong‐Qiang Liu   +9 more
wiley   +1 more source

Evaluation and assimilation of Arctic Weather Satellite data in the AROME‐Arctic forecast system

Quarterly Journal of the Royal Meteorological Society, EarlyView.
The Arctic Weather Satellite (AWS), launched in August 2024, is a prototype for the future EPS–Sterna constellation of small satellites carrying an innovative microwave sounder. We present the first assessment of AWS in the regional AROME‐Arctic numerical weather prediction system, covering post‐launch calibration results and the impact of AWS ...
Stéphanie Guedj, Per Dahlgren, Máté Mile   +2 more
wiley   +1 more source

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source

Metastatic Urachal Carcinoma With Microsatellite Stability and Low Tumor Mutational Burden Achieving a Durable Response to Pembrolizumab After Platinum Failure. [PDF]

IJU Case Rep
Ito F, Kobayashi K, Hayashi G, Kamijo S, Fujita T.   +4 more
europepmc   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

Reference-Free Microsatellite Instability Detection from Tumor Sequencing Using Intrasample Variability Modeling. [PDF]

Comput Struct Biotechnol J
Vlachos G, Moser T, Patel M, White JR, Pischler C, Glawitsch L, Bauernhofer T, Jost P, Edlinger L, Kashofer K, Geigl JB, Diaz LA, Heitzer E.   +12 more
europepmc   +1 more source

Prioritizing areas for wolf management in Austria by modelling potential habitat and depredation risk

Wildlife Biology, EarlyView.
The recovery of wolf populations across Europe has reignited human–wildlife conflicts, particularly in countries such as Austria, where wolves have been absent for more than a century. Livestock depredation remains one of the primary sources of tension, and effective management requires a solid spatial basis for planning.
Florian Kunz, Luca Fuchs, Matthias Amon, Klaus Hackländer, Jörg Fabian Knufinke, Jennifer Hatlauf   +5 more
wiley   +1 more source