Two Decades of Multimodal Management of Colorectal Liver Metastases With Long‐Term Outcomes
ABSTRACT Background The management of patients with colorectal liver metastases (CRLM) is complex and requires a tailored approach based on disease extent, patient age, and comorbidities. Given the heterogeneity in presentation and evolving treatment algorithms, prognostic factors for long‐term survival following liver resection are contested.
Ali Mohtashami +9 more
wiley +1 more source
GT-Seq Panel Development for Species Identification and Parentage Analysis of Closely Related Hybridising Scaphirhynchus Sturgeons. [PDF]
Huang J +5 more
europepmc +1 more source
Genetic risk factors in Finnish patients with Fuchs endothelial corneal dystrophy
Abstract Purpose To study the genetic risk factors of Fuchs endothelial corneal dystrophy (FECD) in the Finnish population using hospital‐based and large biobank cohorts. Methods We genotyped a cohort of 107 Finnish patients with FECD for the primary associated genetic risk factor, the TCF4 (CTG)>50 expansion, and studied their clinical phenotype.
Inka‐Tuulevi Vähämäki +10 more
wiley +1 more source
Concordance Analysis of Microsatellite Instability via NGS and Mismatch Repair Deficiency via IHC in Endometrial and Colorectal Cancer. [PDF]
Nero C +22 more
europepmc +1 more source
This integrated high‐resolution copy number and histomolecular analysis of diffuse hemispheric glioma, H3 G34‐mutant expands the spectrum of associated genetic changes and underscores the presence of universal TP53 abnormalities at copy number, sequence, and protein expression level, with frequent yet largely unrecognized TP53 copy‐neutral loss of ...
Jorge A. Trejo‐Lopez +28 more
wiley +1 more source
An Assessment of the Population Dynamics and Evolutionary History of the Dingo. [PDF]
Pacioni C, Stephens D.
europepmc +1 more source
Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
wiley +1 more source
Genetic structure of sugar kelp in the St. Lawrence Estuary and Gulf (Québec, Canada). [PDF]
Treillefort M +9 more
europepmc +1 more source
Genomic selection using different marker types and densities [PDF]
A. K. Sonesson +15 more
core +1 more source

